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High Flow Nasal Oxygen For Hypercapnic, Acidotic Exacerbation Chronic Obstructive Pulmonary Disease. (HicaP)

To assess the feasibility of a larger study comparing HFNO with NIV as first line treatment in hypercapnic, acidotic AECOPD.

Study on the effect of biperiden and donepezil on attention and memory in healthy elderly people

Primary objective• Assess the ability of donepezil to reverse biperiden-induced effects on adaptive tracking performance at timepoint 4h Secondary objectives• Evaluate the PK of donepezil and biperiden• Investigation of pro-cholinergic effects of…

An exploratory, multi-centre, two-part study to describe chronic induced urticaria characteristics and explore novel biomarkers with a multimodal patient profiling approach by comparing CIndU patients to chronic spontaneous urticaria patients and healthy volunteers

The objective of this study is to deep phenotype CIndU (subtype SD and ColdU) and detect novel biomarkers for diagnosis and treatment response as well as establish methodologies for (non-) invasive monitoring of treatment effects in chronic…

Expertise Asthma COPD Program with Digital Support

The aim of the EXACT@Home study is to further improve the assessment of treatable traits in patients with difficult to treat to severe asthma using ehealth before considering treatment with biologics.

Research into the suitability of the NeuroKit test method in measuring drug effects

Primary Objectives: Quantify the PD effects of CNS active compounds with distinct mechanisms of action (lorazepam, modafinil and S-ketamine) with NeuroKit and NeuroCart in healthy male and female participants.   Estimate the…