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High Flow Nasal Oxygen For Hypercapnic, Acidotic Exacerbation Chronic Obstructive Pulmonary Disease. (HicaP)

To assess the feasibility of a larger study comparing HFNO with NIV as first line treatment in hypercapnic, acidotic AECOPD.

FiberUP

To investigate the feasibility of increasing preoperative dietary fiber intake in CRC patients undergoing surgery via 1) personalized dietary advice (Vezel-UP tool), or 2) vegetable product containing natural fibers (WholeFiber) compared to 3)…

Bifurcation PCI with a hybrid strategy with drug eluting balloons versus a stepwise provisional two-stent strategy. A randomized controlled single-blinded multicentre trial and registry

In this study we will compare a hybrid DEB strategy with a conventional bailout 2-stent strategy (TAP/T-stenting or Culotte) in patients with a bifurcation lesion with sub-optimal side-branch result. The primary endpoint will be the composite…

IMPROVING GASTROINTESTINAL FUNCTION IN HIGH-RISK NEWBORNS BY STIMULATION OF THE ENTERIC NERVOUS SYSTEM

Primary objective: determine whether HAPTOS intervention results in earlier attainment (postnatal days) of full enteral feeding and/or full oral feeding (postmenstrual age) compared to standard care. Secondary objectives: To determine whether…

An interventional, prospective IVD device study for the testing of DNA extracted from tumor tissue biopsy samples from adult participants with metastatic Non-Small Cell Lung Cancer (NSCLC) for potential inclusion in the MSD Phase 3 clinical trial (Protocol No MK-1084-004) to demonstrate clinical performance of the therascreen® KRAS RGQ PCR Kit.

To utilize the therascreen KRAS RGQ PCR Kit (KRAS Kit) as a screening test to identify KRAS G12C mutations in newly diagnosed metastatic NSCLC participants and thereby determine eligibility for enrolment into the Phase 3 clinical study (MK-1084-004…