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Clinical and biological follow-up of children and young adutls prior to, during, and after CAR T-cell therapy, prospective single-centre study (CABRIO)

To determine the real world response to standard of care CAR T-cell therapy, in order to better understand the intrinsic and extrinsic factors related to treatment success or failure.

Collection of biomaterial for iPSCs to study the molecular mechanisms underlying monogenic epilepsies

We aim to collect blood cells from 40 patients with monogenic epilepsy, with a preference for patients with a pathogenic variant in SCN1A, reprogram these cells into iPSCs and use these iPSCs for differentiation into neurons and neuronal organoids…

Comparison of outcome in cLEft palate surgery After different types of surgical Repair techniques

The aim of this study is to compare the outcomes after three different surgical techniques, namely straight line closure, Z-plasty closure and closure using cheek flaps, with regard to speech outcomes and postoperative complications by means of a…

Safety and efficacy of nadroparin in children: an observational study.

Therapeutic nadroparin administration:Primary objective: To develop evidence-based dosing regimens of nadroparin for children in different age groups by means of the objectification of the PK/PD of nadroparin.Secondary objective: 1) Investigate the…

The measurement of EEG in combination with auditive stimuli (ERP) and visual stimuli (eyetracking), and OCT to obtain reference values in healthy typically developing children (0-18 years).

Our primary objective is to collect normative reference values in typically healthy developing children, aged 0 - 18 years, for EEG in combination with ERP and eyetracking, and OCT measurements (For details see also paragraph 5.1).