1600 results
To obtain comprehension in the development of quality of life during and after clinical rehabilitation and the factors that influence it. This leads to the following questions:Primary questions(1) What is the progress of mental health and well-being…
1. Is passive movement therapy an effective intervention on the severity of paratonia in comparison with usual care without passive movement therapy?2. Is passive movement therapy an effective intervention for improvement of daily care?
To establish one large overarching cohort including all types of SpA (both non-radiographic, radiographic axial SpA and peripheral SpA) regardless of the disease stage and treatment and to longitudinally asses several disease aspects of SpA. The…
Main objectives: To obtain true population-based prevalence and incidence figures, as well as insight in the natural history of PSC and PBC in The Netherlands.Secondary objectives: to determine risk factors correlated with PSC and PBC respectively,…
Primary* To compare the efficacy (Major Molecular Response, MMR, rate at 12 months) Secondary* To compare the rate of durable MMR at 24 months in patients with a MMR at 12 months* To compare the rate, time to and duration of complete cytogenetic…
Primary objective· • To investigate the safety and tolerability and establish either the dose of KU-0059436 which causes inhibition of PARP in combination with an active dose of carboplatin or the maximum tolerated dose (MTD) of KU-0059436 in…
To evaluate the cost-effectiveness of the Demands and Capacities Model based treatment (Dutch standard) compared to the Lidcombe programme for early stuttering intervention.Follow-up: Long-term outcome, taking into account recent genetic findings.
To study the presence, number, type and specificity of tumour-specific immune response in the peripheral blood, tumour-draining lymph nodes and the tumour of patients with different types of HNSCC at different time-points during their normal…
To evaluate the efficacy ofa. early intensification of rituximab combined with 2-weekly CHOP+G-CSF (R-CHOP14) in remission induction treatment in comparison to standard R-CHOP14b. maintenance treatment with rituximab in patients in remission after R…
This study has been transitioned to CTIS with ID 2024-518269-92-00 check the CTIS register for the current data. The objective of the study is to gather more information about the long-term effect of enzyme therapy in patients with Pompe disease…
The objective of this study is to assess the clinical presentation, the treatment and the complications of treatment in moderate and severe von Willebrand disease. Another goal is to investigate the influence of von Willebrand disease on quality of…
In addition to the aforementioned passive monitoring of high-risk persons with respiratory complaints after exposure to HPAI, this project aims to set up active monitoring (exclusion diagnosis) in high-risk persons without respiratory complaints in…
Identification of type 2 diabetes susceptibility genes in the Duch population.
The hypothesis is that patients with chronic kidney disease will meet treating goals better when they are treated in a shared care model by a general practitioner, a practice nurse and with online consultation of a nephrologist.
The primary hypothesis is that an association exists between the presence of a niche and abnormal uterine bleeding in women who had a previous caesarean section.
It is generally accepted that the early-postoperative flow increase is indicative for successful maturation of an autologous arteriovenous fistula. Our hypothesis is that a patient-specific computer simulation model should be able to predict this…
Implementation of Colorectal Cancer Screening with FOBT in the Netherlands is feasible
Thrombus aspiration compared to balloon angioplasty will improve myocardial reperfusion during primary percutaneous coronary intervention.
Forlax and transipeg are equally effective in treating childhood constipation.
Simvastatin (an HMG-CoA reductase inhibitor) induces apoptosis in vitro and sensitizes the myeloma cell to chemotherapy. This is the first clinical trial to test if in vivo there is the same sensitization in relapse or refractory multiple myeloma.