2170 results
To investigate whether recently identified patient-specific factors can predict the occurrence of anastomotic leakage in patients undergoing elective surgery for colorectal cancer. Secondary: to develop a predictive model/diagnostic algorithm for…
The primary aim of this study is to document with quantified measurements the natural history of Duchenne Muscular Dystrophy. Several validated tools will be used to describe motor, orthopedic and respiratory functions, and quality of life along a 6…
In this extension study, the long-term safety, tolerability and efficacy of UCB0942 will be studied when used as an adjunctive therapy for partial seizures in adult volunteers with high drug resistant partial epilepsy.
In view of this uncertainty in which current practice in IVF is applied in *older* women, we propose a nationwide randomized trial comparing IVF with natural conception.
Primary: To characterize the safety and tolerability of LXH254 single agent and to identify recommended doses for future studies in adult patients with advanced solid tumors harboring MAPK pathway alterations.To characterize the safety and…
This study has been transitioned to CTIS with ID 2023-508606-26-00 check the CTIS register for the current data. Primary Objective:The primary objective is to compare the radiographic progression-free survival (rPFS) ofapalutamide in combination…
The objective of the induction/consolidation chemotherapy randomisation (R1) is to compare: - VIDE strategy: vincristine, ifosfamide, doxorubicin and etoposide (VIDE) as induction chemotherapy and vincristine, actinomycin D and ifosfamide (VAI),…
Primary Objective- The primary objective of the study is: * to compare DFS between subjects randomized to nabpaclitaxel plus gemcitabine and subjects randomized to gemcitabine alone.Secondary Objectives- The secondary objectives of the study are to…
The primary objectives are to investigate multiple aspects of FDM in patients with AD, MCI and PD compared to healthy controls and to investigate whether FDM problems in these patients can be related to specific neurocognitive dysfunctions. The…
To establish (i) whether or not pre-operative determination of cell-free DNA (cfDNA) and circulating tumor cells (CTC), alone or in combination with each other, in peripheral blood of CRC patients with isolated colorectal liver metastases (CRLM)…
Primary Objectives- To evaluate the pharmacokinetics and safety of the Dara-MD SC delivery of daratumumab (Part 1).- To evaluate the pharmacokinetics and safety of the Dara-CF SC delivery of daratumumab (Part 2).-To evaluate the safety of Dara-CF…
To investigate the efficacy of lanreotide therapy as compared to placebo in patients with NFMA and positive pituitary somatostatin receptor imaging using Gallium-68 DOTATATE PET/CT, on tumor size.
The primary objective of this research project is to further validate the fatigue resistance test by comparing muscle endurance outcomes obtained by the Martin Vigorimeter and the Jamar Dynamometer in subjects of different ages and clinical…
In this pilot, we aim to improve the detection rate of LM by using the CellSearch technique quantifying circulating tumor cells (CTCs) in cerebrospinal fluid (CSF, i.e. CSFCTs) and compare this with the current standard of care; namely cytological…
Primary: To identify biomarkers and clinical parameters that determine and predict the longitudinal course of pSS, taking into account patient-reported, functional, imaging, histopathological, laboratory and genetic data. Secondary: A) To identify…
Our primary objective is to evaluate the effect of an enhanced perioperative care program added on to usual care on the incidence of SSI. Secondary objectives are to evaluate SSI rate at 3 months follow-up, assessment of health and disability with…
Primary Objective: 1) To assess the short- and long-term prevalence of AMR genes in the microbiome of the gut in infants exposed to broad-spectrum antibiotics in the first week of life compared to controls. 2) To investigate the short- and long-term…
Primary Efficacy ObjectivesUnless otherwise specified, efficacy objectives will be analyzed for the following two treatment comparisons:• Atezolizumab + carboplatin + paclitaxel + bevacizumab (Arm B) versus carboplatin + paclitaxel + bevacizumab (…
Aims of the study are to 1) further clarify the construct of SDM for oncology; 2) find ways to operationalize SDM-realization and formulate drafts of a patient and oncologist version of a SDM-realization questionnaire; 3) validate the questionnaires…
Primary objective of this study: To establish glycocalyx properties of temporal lobe epilepsy (TLE) patients. Secondary objectives of this study:- To establish differences in glycocalyx properties of glycocalyx between TLE patients and controls.- To…