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A Multi-Center Randomized Single-Blind Two Arm Intervention Study Evaluating Irreversible Electroporation for the Ablation of Prostate Cancer

Primary: - To evaluate differences in side effect profile of patients treated with focal or extended ablation performed with image-guided IRE for the ablation of prostate carcinoma. - To evaluate differences in quality of life of patients treated…

A Phase 1, Multinational Study of MCLA-117 in Acute Myelogenous Leukemia

Primary:To assess the safety and tolerability of MCLA-117, in order to determine the MTD/RP2D and frequency of administration.Secondary:- To assess the pharmacokinetic (PK) profile of MCLA-117 i.v. infusion- To investigate the pharmacodynamic (PD)…

A step-up approach: CRP first followed by CT-scan imaging to
ensure Quality Control after Major Abdominal Surgery. the
PRECious trial

Aim of the PRECious trial is to evaluate the effect of a standardized postoperative algorithm for quality control (via standardized measurement of CRP levels and CT-scan imaging) on morbidity and mortality after major digestive surgery.

ESTABLISHING THE DIAGNOSTIC AND PROGNOSTIC ROLE OF NARROW BAND IMAGING
IN HEAD AND NECK CANCER

to establish the diagnostic and prognostic value of Narrow band Imaging (NBI) in head and neck cancer

BIoresorbable polymer-coated ORSIRO versus durable polymer-coated RESOLUTE ONYX stents [BIONYX]: A randomized Trial With stENT Evaluation in all-comers IV [TWENTE IV]

The aim of the study is to compare the outcome of the bioresorbable polymer coated stent (ORSIRO) and a new generation permanent polymer coated stent (RESOLUTE ONYX) in an allcomers patient population and non-inferiority setting.

Q-VaxCelerate: Development of a T Cell-Based Vaccine for Q Fever

Identification of T cell epitopes that will serve as the basis for a novel Q fever vaccine with fewer side effects. This will be done by determining ex vivo the effect of Cb-derived T cell epitopes on IFN-γ production in blood of healthy volunteers…

SOLAR-1: A phase III randomized double-blind, placebo controlled study of alpelisib in combination with fulvestrant for men and postmenopausal women with hormone receptor positive, HER2-negative advanced breast cancer which progressed on or after aromatase inhibitor treatment (CBYL719C2301)

Primary: The primary objective is to determine whether treatment with alpelisib in combination with fulvestrant prolongs progression free survival (PFS) compared to treatment with placebo in combination with fulvestrant based on local radiological…

Natural History Study of Acute Hepatic Porphyria (AHP) Patients with Recurrent Attacks.

To characterize the natural history and clinical management of AHP patients with porphyria attacks.

A Phase III, Randomized, Open-label, Controlled, Multi-Center, Global Study of First-Line MEDI4736 Monotherapy and MEDI4736 in Combination with Tremelimumab Versus Standard of Care Chemotherapy in Patients with Unresectable Stage IV Urothelial Cancer

To assess the efficacy of MEDI4736 + tremelimumab combination therapy versus SoC in terms of OS in patients with UC.

A Phase 3, Open-label, Rollover Study to Evaluate the Safety and Efficacy of
Long term Treatment With VX 661 in Combination With Ivacaftor in
Subjects Aged 12 Years and Older With Cystic Fibrosis, Homozygous or
Heterozygous for the F508del CFTR Mutation

Main objective:Part ATo evaluate the long-term safety and tolerability of VX-661 in combination with ivacaftor in subjects with CF, homozygous or heterozygous for the F508del-CFTR mutation who are in the Treatment Cohort.Part B and Part CNot…

Multinational, multicentre, prospective, open-label, uncontrolled clinical trial to assess the efficacy and safety of Autologous Cultivated Limbal Stem Cells Transplantation (ACLSCT) for restoration of corneal epithelium in patients with limbal stem cell deficiency due to ocular burns

Objectives in adult patientsPrimary Objective:To demonstrate the efficacy of Holoclar® at one year after the first treatment in patients suffering from moderate (vascularization in two-three corneal quadrants with central corneal involvement) to…

An Exploratory Phase 2, open-label, single-arm, efficacy and imaging Study of Oral Enzalutamide (MDV3100) Androgen Receptor (AR)-Directed Therapy in Hormono-Sensitive patients with Metastatic Prostate Cancer.

1. To evaluate the feasibility of 18F-FDG PET/CT, or WB MRI or both to determine metastatic tumour load before and after treatmentwith Enzalutamide in patients with metastatic prostate cancer.2. To evaluate how these 2 imaging modalities perform…

Non Invasive Cancer Test (NICT) : a pilot study

To test if the NIPT approach is capable of detecting ctDNA in patients diagnosed with four different types of cancer.

Induced pluripotent stem cell-derived 3D models to unravel the phenotypic diversity of arrhythmogenic cardiomyopathy

Our main objective is to investigate whether the diversity between identical mutations is merely caused by environmental factors, or whether genetic factors also underlie the manifestation of the disease. With this study, we aim to use ACM patient-…

Procedural sedation for hysteroscopic myomectomy: cost effectiveness

Is hysteroscopic resection of submucous myomas under procedural sedation with propofol (PSA) in an outpatient setting a cost-effective alternative for hysteroscopic myomectomy performed under general anesthesia in the operation room?

Long-term effect modification by age of methylphenidate on the development of the dopaminergic system in the brain

Primary objective of the study: 1. To report on the long-term effect modification by age of MPH treatment on the outgrowth of the DA system using state-of-the-art Magnetic Resonance Imaging (MRI) techniquesSecondary objectives:1. To report on the…

Multicenter Randomized Study of the MiStent Sirolimus Eluting Absorbable Polymer Stent System (MiStent SES) for Revascularization of Coronary Arteries, the DESSOLVE III Study

This protocol will provide data to comply with regulatory requirements as well as gain substantial additional information on patients in a real world setting. This protocol will compare clinical outcomes of the MISTENT and XIENCE in a broad patient…

Imaging the retina for early diagnosis in Alzheimer's disease

This proof-of-concept study aims to non-invasively detect amyloid-beta (Aβ)-plaques in the retina of AD patients using a Heidelberg Spectralis scanner with Curcumin as labeling fluorophore. The retinal Aβ-plaques will be related to currently used AD…

A Randomized, Double-Blind, Phase III Study of Platinum+Pemetrexed Chemotherapy with or without Pembrolizumab (MK-3475) in First Line Metastatic Non-squamous Non-small Cell Lung Cancer Subjects (KEYNOTE-189).

Primary Objective1. To evaluate the antitumor activity of pembrolizumab in combination with chemotherapy compared with saline placebo in combination with chemotherapy using PFS per RECIST 1.1 as assessed by BICR of imaging.2. To evaluate the…

A Phase 1 Study of BLU-285 in Patients with Gastrointestinal Stromal Tumors (GIST) and other Relapsed and Refractory Solid Tumors

Primary Objective:Part 1:- To determine the MTD and recommended phase 2 dose (RP2D) of avapritinib.- To determine the safety and tolerability of avapritinib.Part 2:* To determine the overall response rate (ORR) by RECIST criteria at the MTD/RP2D of…