2170 results
The goal of this study is to document the efficacy of a shortened 8-week therapy with grazoprevir and elbasvir in patients with acute HCV genotype 1 or 4 infection.
The overall aim of this study is to elucidate the neural correlates of the effect of social exclusion on social decision-making in chronically rejected and stable accepted children. The secondary aim is to investigate whether deviant sensitivity…
The primary objective of the study is to evaluate the effect of macitentan on right ventricular and hemodynamic properties in patients with symptomatic PAH.Secondary objectivesTo evaluate the safety and tolerability of macitentan in patients with…
The aim of this study is to examine the daily level of activities and participation after LTH in children and adolescents (6-18 years) and to identify possible predictors. In addition, experimental research is done in a subgroup to measure the…
To investigate the effect of a GFC regarding major adverse events (AE) with a relationship to the treatment / residential status / immobilization (as defined under "Primary outcome measures") from surgery to a 36 month follow-up.
The primary objectives of this study are to:* Determine the safety, tolerability, maximum tolerated dose (MTD), and recommended Phase 2 dose (RP2D) of oral BAY 1217389 given in combination with intravenous (IV) paclitaxel using an intermittent…
To determine whether time to functional recovery is shorter after LDP than after ODP for symptomatic benign, premalignant and malignant disease of the distal pancreas in an enhanced recovery setting.
Primary ObjectivePhase Ia* To determine the maximum tolerated dose (MTD) and/or recommended Phase II dose (RP2D)and assess the safety of single agent GDC-0810 in postmenopausal women with locally advanced or metastatic estrogen-receptor-positive (ER…
To evaluate the long term safety and tolerability of GWP42003-P, as adjunctive treatment, in children and adults with inadequately controlled DS or LGS.All Patients:To evaluate the effect of GWP42003-P, as adjunctive treatment, on:* Quality of life…
The purpose of the study is to evaluate the usability of PatientCoach by patients with asthma and/ or COPD,hypertension and/or Diabetes Mellitus.
This study is part of a prospective cohort study in the University Medical Center Groningen aimed at the determination of prognostic factors for outcome of children with TBI. The study is a pilot study to determine the value of fNIRs for detection…
Aim1. To investigate the long-term effects of early detection and intervention of hearing loss on the development of children with congenital bilateral hearing impairment. 2. To define factors in early childhood that are able to predict…
In this study, we aim to test the feasibilty, reliability and validity of the MOX-accelerometer in measuring daily physical activity in children with mitochondrial disease.
Physical functioning at the workplace in patients after total knee arthroplasty: a feasibility study
The primary aim of this pilot study is to demonstrate the feasibility of measuring physical functioning at the workplace among TKA patients and healthy colleagues objectively. Secondly, to get a first impression of objective physical functioning of…
Primary Objective: The painscores regarding abdominal pain among women with primary outflow obstruction in comparison with an age matched control group.Secondary Objective(s): The prevalence of sexual problems due to the congenital anomalies or the…
To investigate the feasibility and efficacy, expressed as percentage funcitoning time and time in target range, respectively, of an automated closed-loop glucose control system based on subcutaneous continuous glucose measurements in critically ill…
To validate the use of single urethral sensor catheter in demonstrating urethral pressure variations during filling cystometryIncidence of significant urethral pressure variations during urodynamic filling phase measured with three urethral sensor…
Primary objective of the study is to determine the effect of 2 different treatment strategies of vitamin D supplementation on 25(OH)D3 serum concentration after 12 months of supplementation. Secondary objectives are to determine the effects on the…
Primary goal: mean linear wear of the cross-linked polyethylene F.A.L. cup compared to the mean linear wear of the standard polyethylene F.A.L. cup at 5 years postoperatively. Secondary goals:1. mean linear wear (millimeters/year) at 1 year, 3 years…
The primary objective of our study is to investigate the performance of FCH-PET as a second-line imaging modality for localizing hyper-functioning parathyroid gland(s) in patients with biochemically proven PHP for whom surgery is indicated, thereby…