Search for a trial

Cervical split laminectomy vs conventional cervical laminectomy for treatment of cervical myelopathy

The purpose of this study is to evaluate the long-term results of the split laminectomy and compare these resultsit to the long-term results of the conventional laminectomy. The prevalence of kyphosis and segmental instability is being investigated…

Improving risk stratification for infarction related sudden cardiac death by combining cardiac magnetic resonance imaging, electrocardiographic imaging and epicardial mapping.

The aim of this study is to discover a new set of parameters to define the electropathological substrate by integrating cardiac magnetic resonance imaging (CMR) and non-invasive electrocardiographic imaging (ECGI) characteristics. In the future,…

Assessment of the responsiveness of the Rasch-built, CIPN-specific questionnaire (CIPN-RODS) to clinical changes in patients undergoing neurotoxic chemotherapy.

Primary Objective: to assess formally the responsiveness of a core set of measures derived from the previous CI-PeriNoms Study (Cavaletti, et al., 2013).Secondary objective: to test the responsiveness of the CIPN specific Rasch-built Overall…

Safety and Performance study of the C-Life Investigational Electrode for subject-controlled, on-demand, dorsal genital nerve stimulation to treat urgency urinary incontinence.

Objective: Safety and performance of the C-Life Investigational Electrode, and to determine the clinical value for conditional dorsal genital nerve stimulation in patients with overactive bladder syndrome.

Towards a clinical trial for oculopharyngeal muscular dystrophy (OPMD) - natural history and outcome measures.

The primary objective is to identify clinical outcome measures in OPMD patients to support the future development of treatment strategies for OPMD. The secondary objectives are:• To identify molecular biomarkers for OPMD in biofluids to monitor…

zie C1b

Zie K1

Continuous glucose monitoring versus self-monitoring of blood glucose in women with gestational diabetes mellitus

The hypothesis is that SMBG underestimates the number of hyperglycaemic episodes in women with gestational diabetes mellitus. The aim of this study is to evaluate if CGMS detects hyperglycaemia when the standard SMBG day curve is normal.

A Phase 1 Randomized, Placebo-Controlled, Double-Blind, First- Time-in-Humans, Single-Ascending Dose (SAD) and Multiple- Ascending Dose (MAD) Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CNM-Au8 in Healthy Male and Female Volunteers

Primary objective:To evaluate the single- and multiple-dose safety and pharmacokinetics of CNM-Au8 upon oral administration of CNM-Au8 to healthy adult male and female subjects.Secondary objective:Exploreing the immune-modulating effects of CNM-Au8…

Tight control dose reductions of biologics in psoriasis patients with low disease activity: a randomized pragmatic trial.

To investigate whether the dose of biologics can be reduced in patients with psoriasis with stable disease: is dose reduction non-inferior to the current practice regarding clinical effectiveness? Secondary aims are: to investigate what influence…

Fifteen years of statin therapy started in childhood: efficacy, safety, compliance and tolerability in patients with familial hypercholesterolemia

The aim of this study is to evaluate the efficacy, safety, compliance and tolerability of 15 years of pravastatin therapy initiated during childhood in young adult FH patients.

Phase III, open-label, multi-center study to assess the pharmacodynamic (PD), pharmacokinetic (PK) and safety of Zoreline 10.8 mg goserelin subcutaneous implant (Novalon) in male patients with prostate cancer

To assess the PD, PK and safety of the Zoreline 10.8 mg goserelin subcutaneous (SC) implant.

Day-night rhythmicity in patients with a nonfunctioning pituitary macroadenoma; a prospective study

Research question:1. Do patients exhibit disturbances of sleep duration or circadian locomotor rhythmicity before surgery? 2. Do these variables change after surgery?

Stress ulcer prophylaxis with proton pump inhibitor (pantoprazole) in adult critically ill patients in the intensive care unit: A randomized, blinded, placebocontrolled trial

To assess the benefits and harms of SUP with PPI in adult, critically ill patients in the ICU.

Trans-abdominal ultrasound as a point-of-care test for the assessment of disease activity in patients with ulcerative colitis

The primary objective of this study is to develop an ultrasound-based activity index with appropriate cut-off values that can be used as a point-of-care test for the assessment of mucosal disease activity in UC patients. Secondary objectives of this…

The Effect of Vitamin D status on Fracture healing - a prospective cohort study

The influence of the initial vitamin D status on the fracture consolidation will be studied. These study results might give rise to a randomised controles trial with vitamin D supplementation in order to investigate the effect of supplementation on…

A randomized, double blind, crossover, placebo controlled class-room experiment to assess the pharmacodynamics and pharmacokinetics of metoprolol in healthy volunteers with different polymorphism of CYP2D6

Primary Objective• To educate students about the full life cycle of clinical trials including study set-up, design, execution, analysis and reporting• To explore the influence of CYP2D6 polymorphism on the pharmacodynamics and pharmacokinetics of…

A phase 3 extension study of Ataluren (PTC124) in patients with Nonsense Mutation Cystic Fibrosis

Primary objectiveTo evaluate the long-term safety of 10-, 10-, 20-mg/kg ataluren in patients with nonsense mutation cystic fibrosis (nmCF), who previously participated in pivotal study PTC124-GD-021-CF, as determined by adverse events and laboratory…

A drug-drug interaction study between the novel anti-HCV agent daclatasvir and the antiretroviral agents atazanavir/ritonavir or atazanavir/cobicistat in healthy volunteers.

Primary objective:To compare the effect of multiple dose atazanavir/cobicistat on the multiple dose phar-macokinetics of daclatasvir with the effect of atazanavir/ritonavir on the multiple dose of daclatasvir by intra-subject comparison in healthy…

EMDR in the treatment of Chronic Fatigue Syndrome (CFS): can EMDR make the perception of fatigue less negative?
A sequential randomized and replicated single-case experimental phase design with multiple measurements.

Primary Objective: The main aim of this study is to investigate if EMDR diminishes negative associations with fatigue in CFS-patients who follow CBT.Secondary Objective(s): Second, we will investigate if EMDR strengthens the belief of the patient…

A SINGLE ORAL DOSE, RANDOMIZED, DOUBLE-BLIND, PLACEBO- AND
POSITIVE CONTROLLED, 4-WAY CROSSOVER STUDY TO INVESTIGATE THE
EFFECT OF CANNABIDIOL (GWP42003-P) ON THE QTC INTERVAL IN
HEALTHY SUBJECTS

The purpose of the study is to investigate the effect of CBD on specific ECG parameters. Importantly, it will be evaluated if there is a prolongation of the QT interval. When the QT interval is prolonged, repolarization of the heart is delayed. This…