2170 results
Genotyping the population of patients with iVF and AF and detecting novel genes associated with iVF and AF. Secondary endpoints are correlation of the presence of gene defects and response to catheter ablation in AF patients and create a better…
The primary objective of this study is to demonstrate that individually optimized, triple-site biventricular pacing is superior to standard biventricular pacing in reversing ventricular modeling as demonstrated by Echo Left Ventricle End-Systolic…
Main objectives are to investigate the cognitive effects of alternating endurance-strength training in APOEe4 carriers and non-carriers in early stage dementia and to identify a dose-response relationship of the cognitive effects of exercise.…
We aim to investigate whether copeptin can be used as an early postoperative marker for development of DI. We will measure copeptin levels in patients just prior to and following transsphenoidal surgery to be able to investigate whether copeptin…
The main objective of this study is to investigate the effectiveness of the humeral and cellular immune response after tetanus revaccination in patients with AChR MG, MuSK MG, or LEMS. The secondary objective is to determine if revaccination induces…
To assess the prospective relationship between social defeat on one hand and psychosis and crime on the other hand in Antillean immigrants to Rotterdam.
The primary objective of the study is to generate safety and performance data for the CardiAQ* Transcatheter Mitral Valve Implant System with the Transapical Delivery System to support a future marketing application for the treatment of moderate to…
This explorative feasibility study will focus on developing a treatment protocol for light therapy in older adults with dementia and a depressive disorder. However, it is important to first consider whether the treatment is feasible at this target…
The primary aim of this study is to determine the effect of nandrolone decanoate (ND) injection and leucine supplementation on muscle mass loss during short-term immobilisation in healthy, young people. In addition, we aim to study the underlying…
In the current study we investigate the safety of the HBAI20 vaccine. Furthermore, the efficacy of the HBAI20 vaccine in non-responders is investigated.
EFFICACY OBJECTIVESThe primary efficacy objective for this study is to evaluate the efficacy of lebrikizumabused as adjunctive therapy with TCS compared with TCS in patients with persistentmoderate to severe AD, as measured by Eczema Area and…
The research question fort his study is: *What are the personal experiences of older hospital patients who have suffered a delirium, their family members, and their handling nurses?*. The aim of the current study is to gather the personal…
Analyse the correlation between baseline MSC level in peripheral blood from cancer patients and their primary tumor type.
Is pulmonary function testing using the Whistler device a feasible method in adults with an intellectual disability? Is pulmonary function testing using the Whistler device a reliable method in adults with an intellectual disability? Does the…
A comparison of the PR-OCT and conventional ways of examination of patients, being slitlamp biomicrsocopy combined with stand alone SD-OCT, and fluorescein / ICG angiography, or glaucoma screening.
Natalizumab (Tysabri®) for the treatment of anti-Hu associated paraneoplastic neurological syndromes
The primary objective of the study is the functional improvement with one point or more on the modified Rankin scale after the 12th week of natalizumab (compared to baseline).
The primary objective of this study is to evaluate the effect op epilepsy surgery of implantation of a Vagus Nervus Stimulator on the subjective and objective measures of sleep quality. Secondly the differences in sleep quality and sleep…
The purpose of this study is to investigate the characteristics of different sub cellular constituents in different body fluids of patients with advanced EOC with different histotypes. Besides obtaining more clarity about the role of these…
Primary objectives To demonstrate the non-inferiority of CHF 5993 pMDI versus fixed combination of fluticasone furoate/vilanterol plus tiotropium in terms of quality of life (change from baseline in the St. George*s Respiratory Questionnaire [SGRQ]…
The objective of this study is evaluation of the effectiveness of CPAP-therapy on recurrence of atrial fibrillation after cardioversion in patients with central sleepapnea and in case of proven effectiveness possibly using CPAP-therapy as standard…