2170 results
Demonstrate whether or not KC causes a significant increase in salivary oxytocin concentration in preterm infants. By gaining more insights into the biological processes that cause the positive effects of KC, we can develop technologies that can be…
The purpose of the study is to investigate to what extent L-1, L-2 and L-3 are tolerated when administered as micro-dose.It will also be investigated how quickly and to what extent L-1, L-2 and L-3 are absorbed and eliminated from the body (this is…
Primary objectives:To assess the bioequivalence of a single-dose TRI as a whole tablet (reference) compared to a crushed and suspended tablet (intervention I).To assess the bioequivalence of a single-dose TRI as a whole tablet (reference) compared…
The purpose of the study is to investigate to what extent LNP1955 is tolerated and safe.It will also be investigated how quickly and to what extent LNP1955 is absorbed and eliminated from the body (this is called pharmacokinetics). Further, the…
Compare the hemodynamic response to pelvic and conventional LBNP and assess head motion.
Primary ObjectiveTo establish a prospective cohort of patients undergoing radiotherapy for breast, prostate or lung cancers following local regimens and collecting standardised radiotherapy toxicity data, non genetic risk factor data and samples for…
Main Objective:To evaluate the long-term safety and tolerability of BYM338 in the treatment of sIBM and to further evaluate the effect of three BYM338dose regimens against placebo in increasing the distance traveled as measured by the 6 Minute…
Primary:To evaluate the effect of MBX-8025 on LDL-C.Secondary:To evaluate the effects of MBX-8025 on other lipid parameters. To evaluate the safety and tolerability of MBX-8025. To evaluate steady-state trough plasma levels of MBX-8025 and its…
Test whether aDBS is superior to continuous DBS (cDBS) in terms of effectiveness, side-effects and energy consumption in patients with Parkinson*s disease (PD) and dystonia.
Objective of the studyThe aim of this study is to optimize the education, psychosocial counselling and guidance for (intended) parents, children conceived by means of DST and the sperm donors. It is the intention that with the findings of the…
Primary Objective: The primary objective is to assess the feasibility of QCA-FFR in our centre. Secondary Objective:To assess the correlation and agreement of QCA-FFR with conventional pressure-wire based FFR. The pressure-wire derived FFR will…
This study is designed to objectively document the physiological impact of a micro-catheter on coronary physiology parameters compared with a contemporary 0.014* sensor-equipped guide wire during both basal and hyperaemic conditions, and to identify…
To gain clinical experience for the Ellipse IM HTO Nail System in subjects with osteoarthritis and varus malalignment of the knee:1. To further evaluate the safety profile of the Ellipse IM HTO Nail System2. To further evaluate the efficacy of the…
To find the effects in satiety related brain regions and satiety related scores of additional gastric distention with similar nutrient load and oro-sensory exposure.
To provide normative data and reference values for oxygen saturation and heart rate in healthy newborns the first 48 hours of life.
What is the level of agreement between the gold standard, which includes invasive DO2 and VO2 measurements (with pulmonary artery catheter and central venous line), when compared with DO2 and VO2 measurements derived by a minimal invasive approach (…
The main objectives of the trial are* To develop innovative evidence*based, feasible, effective and sustainable nutritional strategies for the prevention of depression in EU citizens.* To establish the feasibility and effectiveness of nutritional…
Multiple sensitizations were found using allergy tests, but most of the EoE patients have concurrent allergic diseases and the specific IgE found in serum apparently does not play a role in EoE pathogenesis. This theory is supported by the failure…
1. Determination of the PK of THC, CBD after inhalation of cannabis products Bedrocan©, Bedrolite© and Bediol© 2. Determination of the analgesic effects of THC, CBD and the combination of THC and CBD after inhalation of cannabis products Bedrocan©,…
In this study we want to assess the quality of vaccination status in Dutch families after travel and compare how well they are protected against infectious diseases as prescribed by national vaccination protocolsSecondary, we want to study the…