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Initial Immune Response to New Biomaterials

The exact mechanism behind the observed fast recellularization of the DTEHV constructs is still unknown. A reasonable explanation might be that scaffold remnants inside the tissue-engineered constructs recruit the circulating blood cells. In order…

Pre-implantation genetic haplotyping of embryos using next-generation sequencing

* To demonstrate the basic functionalities (robustness, reproducibility and overall performance characteristics) of the NGS-based haplotyping method.Secondary objective* To demonstrate concordance between embryonic biopsy genetic analysis results…

The influence of Expectation modification in Knee arthroplasty on Satisfaction of PatiEnts, an randomized Controlled Trial

The aim of this study is to examine whether a joint-specific educational module (preoperative education about the recovery of symptoms, physical functioning and psychological well-being (index group)) will improve patient satisfaction after TKA…

Play with the IROMEC robot during rehabilitation and special education for children with severe physical disabilities - an explorative feasibility study.

This study aims to examine the feasibility and an indication of possible effects of an IROMEC robot based play therapy within rehabilitation and special education on the level of playfulness of children with severe physical disabilities.

Implementation study on population based carrier screening via the general practitioner in the northern part of the Netherlands. Research on the implementation of a clinically validated population based carrier screening test for couples with a child wish.

This study aims to investigate whether the clinically validated population based expanded preconception carrier screening (PCS) test, developed by the Department of Genetics of the UMCG, can be implemented responsibly via the general practitioner as…

An observational cross sectional cohort study to estimate the frequency of hepatitis E virus (HEV) infection in neurological disease of inflammatory/ immune mediated origin and ischemic stroke

To estimate the frequency/ prevalence of acute or active HEV infection in patients presenting with (sub)acute post-infectious and/or immune-mediated neurological illness like neuralgic amyotrophy, (idiopathic) Guillain Barre syndrome, idiopathic…

A randomised, double-blind, placebo-controlled, single ascending dose/multiple dose study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of KBP-042 in healthy adult male volunteers.

1. To evaluate the safety and tolerability of ascending single/multiple doses of KBP-042 in healthy male subjects;2. To evaluate the pharmacokinetics of ascending single/multiple doses of KBP-042 in healthy male subjects;3. To assess the biological…

Virtual Reality as pain relief during colonoscopies - Psychological factors related with the effect of Virtual Reality during colonoscopies

Primary objective: to investigate which independent variables (gender, age, abdominal pain during previous month, previous abdominal surgery, fear, locus of control, coping and focused attention) were related to the patients which are able to…

Amino acid bioavailability of different proteins

The primary objective of this study is to investigate whether a protein mix is related to a faster postprandial amino acid bioavailability compared to a milk protein.

Cardiac Remodeling and Myocardial Perfusion following Mitral Valve Repair with the MitraClip Device

To study the effect of the MitraClip implantation on myocardial performance as determined by changes in left ventricular end diastolic volume and myocardial perfusion.

Contrast enhanced ultrasound to measure cerebral blood flow

This protocol is a first pilot study to determine both feasibility and reproducibility of CEUS in the quantification of CBF. Aim of the current study is to determine the reproducibility of CEUS in quantification of cerebral blood flow, compared to…

An Exploratory Multicenter, Double-Blind, Diphenhydramine- and Placebo-Controlled Safety, Efficacy and Biomarker Study with JNJ-42847922 in Subjects with Major Depressive Disorder.

Primary Objective:To investigate the safety and tolerability of JNJ-42847922 in subjects with MDD. Study medication will be administered for 10 days in women of childbearing potential (WOCBP) or for 4 weeks in all other subjects.Secondary Objectives…

Bubbling therapy for dysfunctional breathing in difficult to treat asthma - a pilot study

To determine the effect of bubbling therapy on asthma control in patients with difficult to treat asthma and dysfunctional breathing.

Dance for Health: The effect of a dance program on patients with Multiple Sclerosis

The aim of the current pilotstudy is to investigate the effect of a standardized dance program (provided by the foundation Dance for Health) in MS patients. We will specifically investigate the effect of the dance program on the hippocampus and (…

Discontinuation versus continuation of antiarrhythmic drugs prior to pulmonary vein isolation for atrial fibrillation and influence on dormant conduction with adenosine; a randomised controlled trial.

Comparing incidence of dormant conduction after adenosine challenge and initial succesfull PVI in a strategy of cessation of antiarrhythmic drugs compared with continuation prior to PVI.

A clinical prospective feasibility study to address the effectiveness and safety of calciumphosphate/poly(lactic-co-glycolic-acid) for bone augmentation in maxillary sinus floor elevation surgery.

The primary objective is to determine the feasibility of applying CPC-PLGA in sinus floor elevation surgery in terms of bone formation and implant survival. The secondary objective is to investigate pain, health-related quality of life and the…

Follow-up of intracranial aneurysms treated with the Surpass flow diverter: comparison of subtraction CTA and DSA. Part II: a retrospective selected case series.

Primary objective: -To determine the accuracy of sCTA compared to DSA in the visualisation of the degree of occlusion in the FU of intracranial aneurysms treated with Surpass. Secondary objectives:-To determine the accuracy of sCTA compared to DSA…

Pharmacokinetic analysis of HPV16 synthetic long peptide vaccination in healthy volunteers using optical imaging

To assess safety, tolerability and pharmacokinetics of a single subcutaneous administration of HPV-NIRD1.

eSupported lifestyle coaching for patients with insulin dependent type 2 diabetes mellitus: a pilot study

1. to determine the feasibility and acceptability of an e-supported lifestyle coaching program and2. to assess the effects of personalized lifestyle support in patients with insulin dependent type 2 diabetes mellitus immediately after 12 weeks and…

A study in healthy volunteers to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of BN201, an investigational compound for the treatment of acute optic neuritis.

The study will be performed in 2 parts, Parts A and B. The purpose of the study is to investigate to what extent BN201 is tolerated. It will also be investigated how quickly and to what extent BN201 is absorbed and eliminated from the body (this is…