2170 results
Our primary objective is to investigate whether noradrenaline exerts immunomodulatory effects in humans in vivo during experimental human endotoxemia. This will be determined by comparing plasma levels of various pro- and anti-inflammatory cytokines…
To assess if resting membrane potential or ion channel activity is abnormal in sensory axons of affected nerves in MMN patients.
The purpose of the study is to investigate to what extent CBD is safe and tolerated. It will also be investigated how quickly and to what extent CBD is absorbed and eliminated from the body (this is called pharmacokinetics). Furthermore the effect…
The objectives of the study are as follows:Primary:• Part 1: To assess the pharmacokinetics and relative bioavailability of three different formulations of PA101 (4% cromolyn sodium with and without mannitol, and 6% cromolyn sodium without mannitol…
The primary objective is to study how brain and muscles work together during the onset of walking, during turns and during prolonged walking and whether there are differences between healthy individuals and PD patients with and without FOG.…
The main objective of this study is to identify changes in DNA methylation of CD3+ T cells associated with cSCC after organ transplantation.
What is the functional status of patients who have been treated using the dogbone Button technique as surgical treatment or by means of conservative treatment of acute acromioclavicular luxation at least 3 months and up to 24 months after surgery?
Primary objective:The primary objective is the difference between the gammaCore®-R and the sham treatment groups in mean reduction in number of episodic migraine days during the last four weeks in the twelve-week randomized period compared with the…
To investigate the in vitro effect of both pro- and anticoagulation therapy on thrombin generation by Calibrated Automated Thrombography in plasma from patients with cirrhosis undergoing liver transplantation.
To evaluate the long-term (up to 5-years after procedure) efficacy and safety of CA against SA in preventing the recurrence of LA arrhythmias in patients with a history of paroxysmal and/or persistent AF
Objective of the pilot study is to examine whether a pragmatic randomised trial on the effectiveness of manual therapy compared to general practice care in migraine is feasible.For this purpose we use the following questions.* Is it possible to…
The purpose of the study is to investigate the ability of MYL-1401H to evoke an immune response (immunogenicity) as compared to Neulasta® US. In addition, the effect of MYL-1401H on blood cells as compared to Neulasta® US will be investigated. The…
The principal aim of this study is to evaluate the PK parameters of both oral formulations in adult healthy volunteers in order to propose forMarketing Authorization Application an adequate strength for TETA•4HCl (i.e. a strength providing a PK…
The objective of the study is to evaluate the efficacy and safety of a single dose of fosaprepitant when administered concomitantly with ondansetron, with or without dexamethasone, in subjects birth to 17 years of age receiving emetogenic…
To validate and compare smartphone-connected blood pressure monitors produced by Withings, Qardio and iHealth with the gold standard and a validated automatic blood pressure monitor.
Primary Objective: to assess formally the responsiveness of a core set of measures derived from the previous CI-PeriNoms Study (Cavaletti, et al., 2013).Secondary objective: to test the responsiveness of the CIPN specific Rasch-built Overall…
How is a smokers* smoking behavior and topography influencing exposure to cigarette smoke constituents?Primary Objectives: - What is the individual smoking topography of a smoker smoking his usual brand, and does this change between cigarettes over…
Objective: Safety and performance of the C-Life Investigational Electrode, and to determine the clinical value for conditional dorsal genital nerve stimulation in patients with overactive bladder syndrome.
The primary objective is to identify clinical outcome measures in OPMD patients to support the future development of treatment strategies for OPMD. The secondary objectives are:• To identify molecular biomarkers for OPMD in biofluids to monitor…
Primary Objective: To determine the independent and combined effects of mastication duration and orosensory stimulation intensity on satiation. Secondary Objective: To investigate whether chewing behaviour type affects satiation through orosensory…