2170 results
The main objective of this study is to evaluate the effectiveness of the Activate intervention in adult patients at risk for cardiovascular disease (CVD) in primary care. Secondary aims are to identify which patient-related characteristics modify…
1. To evaluate the feasibility of 18F-FDG PET/CT, or WB MRI or both to determine metastatic tumour load before and after treatment with Enzalutamide in CRPC patients. 2. To evaluate how these 2 imaging modalities perform compared to traditional…
Primary Objective: To investigate whether exercise (Diabetes Bootcamp) induces a change in intestinal faecal microbiota (rise of butyrate-producing intestinal microbiota) related to improved glycaemic control (peripheral and hepatic insulin…
The primary objective is to study if quantitative (3- and 7-Tesla) MRI protocols (MRI perfusion, diffusion tensor imaging (DTI), and chemical shift imaging (CSI)) are able to detect phenotype conversion earlier than conventional MRI. Results will be…
Evaluate the effect of menarche and menstrual cycle on the QTc interval among girls with genetically confirmed mutations causing LQTS type 1 (LQT1) and type 2 (LQT2).
The primary objective is to demonstrate the non-inferiority of edoxaban (preceded by a short course of LMWH compared with dalteparin for theprevention of the combined outcome of recurrent venous thromboembolism (VTE) or major bleeding in subjects…
Primary Efficacy Objectives:* To demonstrate the decrease in anti-fXa activity following andexanet treatment.* To evaluate the hemostatic efficacy following andexanet treatment.Secondary Efficacy Objective:* To assess the relationship between…
The OPTIMAL-PORT study aims to demonstrate the non-inferiority of *surgery only* compared to surgery with adjuvant radiotherapy as treatment for impending and actual pathological fractures on the pain experienced by patients.
The primary goal of the present research proposal is to investigate whether emotional arousal plays a role in the effectiveness of EMDR therapy.Recent studies by our group have shown that vivid, emotionally neutral memories cannot be blurred by EM.…
Primary: To determine the optimal dose/recommended dose (RD) of pre-medication dexamethasone around docetaxel infusion.Secondary: * Does a dose reduction of prophylactic dexamethasone around the docetaxel infusion decrease the body*s metabolic…
Primary Objectives: - To determine the maximum tolerated plasma AUC0-12h of high-dose sorafenib administered in a weekly, pulsatile schedule.- To assess the safety and tolerability of high-dose, pulsatile sorafenib. Secondary Objectives:- To…
Primary ObjectiveTo evaluate the clinical efficacy of apremilast (30 mg twice daily [BID] and 40 mg BID), compared with placebo, in subjects with active UC.Secondary Objective To evaluate the safety and tolerability of apremilast (30 mg BID and 40…
The aim of this pilot study is to investigate whether substitution of normal bread by a new palatable form of low salt bread is effective in reducing the daily salt intake in patients with CHF. Furthermore the influence of the presumed salt…
The objective of this study is to examine whether EMDR with flashforward targets can be effective in reducing anxiety related to the future in MS patients. Specifically, following hypotheses will be examined: EMDR with flashforward target…
To study a cohort of HIV infected and HIV uninfected MSM and HIV infected heterosexuals who (subsequently) acquired HCV infection with a known date of HCV seroconversion:1. To identify the frequency, clinical consequences and determinants (viral and…
Primary objective:investigating whether in a large, representative sample of premature born children (gestational age * 30 weeks and/or birth weight * 1000 gram) with attentional problems in the age of 8 - 12, executing the BrainGame Brian training…
To investigate whether cardiac telerehabilitation using a personalized patient-centred ICT platform comprising remote monitoring and coaching of physical activity behaviour results in an improved long-term daily physical activity level as compared…
The overall aim of this study is to develop a short and clinically relevant composite measure, which is able to detect changes in cognition and everyday functioning across the disease spectrum of Alzheimer*s Disease (AD). We will achieve this aim by…
To investigate the association of ITPA genotype and ITPase activity with nephrotoxicity, bone toxicity and recovery of nephrotoxicity and bone toxicity during and after anti-retroviral treatment with a tenofovir containing regimen for HIV.
Evaluate efficacy and safety of risankizumab compared to placebo in patients with severe persistent asthma over a 24-week treatment period.