870 results
1. Evaluate the relation between pretreatment muscle weaknesses, spasticity, abnormal synergies, and changes in viscoelastic joint properties on the one hand, and changes in upper extremity spasticity following treatment on the other hand in…
This study has been transitioned to CTIS with ID 2024-513483-26-00 check the CTIS register for the current data. To assesses the efficacy of Tinlarebant in slowing the rate of growth of atrophic lesion(s) in adolescent subjects with STGD1.
Main research question and primary objective: What is the effect of exposure to high vs. neutral temperature (32* C vs. 25* C) in combination with high vs. low humidity (30 %RH vs. 70 %RH) for 8 hours on cognitive performance?Secondary research…
To examine cognition, motor function, executive functions, speech and language development, behaviour, psychosocial functioning, academic achievement, physical morbidities and growth of MLPTI at the age of 9 years and correlate this with BSID-III-NL…
To determine the effects of the PCP+SM compared with usual care on BP control in adults with hypertension. To determine the effects of the PCP+SM compared with usual care on antihypertensive medication use in adults with hypertension. To determine…
To assess the feasibility of participants positioned in an MRI scanner to regulate their breathing based on biofeedback
The primary objective of this Clinical Investigation is to evaluate the diagnostic yield using the Ion Endoluminal System when used with adjunctive 3D imaging modalities for the biopsy of peripheral pulmonary nodules (PPNs). In a first phase, the…
This study has been transitioned to CTIS with ID 2023-504999-25-00 check the CTIS register for the current data. To investigate wether the treatment of children and adolescents with AML can be improvedby means of:1) improved risk-group adapted…
In this multicenter prospective cohort study we will investigate the feasibility of TE-ST.
To determine the potential impact of ball heading in football on brain integrity as assessed by blood biomarkers for neural damage in a real-world setting.
This study has been transitioned to CTIS with ID 2024-513392-40-01 check the CTIS register for the current data. The design will be a prospective, single center phase I feasibility and dose finding study in patients with high-grade glioma, to…
Primary Objective: To investigate if treatment according to the EMDR protocol for urge reduce daily scratching behaviour in PN patientsHypothesis: Treatment according to the EMDR protocol for urge leads to a statistically significant reduction of…
Objective: to investigate areas of uncertainty about a possible future definitive RCT using AF-EMDR as an add-on intervention to a Smoking Cessation Program (SCP), by determining:• Feasibility/process outcomes (e.g. recruitment, adherence, treatment…
This study has been transitioned to CTIS with ID 2023-503715-14-00 check the CTIS register for the current data. Part A: To characterize the safety, tolerability, and define the MTD or RP2D for the combination of relatlimab + nivolumab in pediatric…
This is a research study. The purpose of this study is to test if the investigational medicinal product S48168 (ARM210) is safe and effective when given to patients diagnosed with CPVT1. Primairy objective:To assess the effect of S48168 (ARM210) on…
The primary objective is to determine whether there is a difference in the capability of the patients to successfully follow the instructions of both the Levodopa Cyclops* and the INBRIJA® inhaler during an off episode, based on the instruction…
The goal of this trial is to determine the efficacy of LC in patients with IAP in the prevention of recurrent acute pancreatitis and biliary events. The secondary goal of this trial is to assess the occurrence of biliary events, complications of LC…
This study has been transitioned to CTIS with ID 2024-515260-31-00 check the CTIS register for the current data. To investigate the potential of preoperative initiation and perioperative continuation until day 2 after surgery of the SGLT2 inhibitor…
Primary Safety Objective: • To evaluate initial safety of UCon for treatment of OAB symptoms in a home setting.Secondary Safety Objective• To demonstrate that subjects using UCon do not experience an unacceptable amount of device- or procedure…
This study has been transitioned to CTIS with ID 2023-507144-36-00 check the CTIS register for the current data. Primary:Evaluate PK and efficacy of ustekinumab and guselkumab in jPsA. Secondary:Evaluate safety of ustekinumab and guselkumab in…