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An observational, non-interventional cohort study to monitor physical and social activity of bladder cancer patients during treatment with curative intent by using conventional and digital methodology

PrimaryTo determine the feasibility of monitoring bladder cancer patients with the Trial@home platform.SecondaryTo correlate social, physical, and physiological data of bladder cancer patients collected from the Trial@home platform with the quality-…

Discovery of biomarkers in cervical smears for diagnosis and prognosis of cervical lesions

To identify molecular biomarker profiles that are associated with cervical tumorigenesis, and that can be used for development of an algorithm for detection of low grade CIN1, CIN2, CIN3 and cervical cancer. The algorithm should provide advice for a…

Clinical investigation of the Qmedics EXIST NiTi Stent type Flex & Pull in adults with Peripheral Artery Disease (PAD) (of the Q-medics NiTi Stent Family.

The objective of the HORIZON trial is to demonstrate and provide long-term clinical data on safety and performance of the Qmedics EXIST NiTi Stent System type FLEX & PULL for treating de novo or re-stenotic symptomatic atherosclerotic…

Glucose response to a formula for patients at risk of hypoglycaemia

The aim of the present study is to assess whether the postprandial glucose response of the new test products is superior to the postprandial glucose response of an original treatment option.

Diagnostic accuracy of the maximal systolic acceleration for detection of peripheral arterial disease in patients with diabetes-related foot ulceration.

The aim of this study is to assess the clinical value of bedside tests compared to DUS to detect PAD in patients with diabetes-related foot ulceration, with special emphasis on the ACCmax.

PREoPerAtive pREhabilitation in patients with Head and Neck Cancer or Liver Cancer

To determine the feasibility (main aim) and effectiveness (secondary aim) of a prehabilitation program in patients with HNC or liver cancer

An intervention to address feelings of shame and guilt related to survival based behavior after (sexual) assault.

The present study proposes to investigate the On(t)schuldig intervention. The main research question: Do adolescents report less trauma-related feelings of shame and guilt after following the intervention On(t)schuldig?

A multi-center, longitudinal 12-week pilot study to evaluate cough severity and its impact, utilizing a next generation cough monitor, in participants with idiopathic pulmonary fibrosis (IPF) or Non IPF Pulmonary Fibrosis

As highlighted, significant gaps in knowledge remain regarding etiology of cough, consequences of cough and appropriate treatment of cough in patients with pulmonary fibrosis. A further understanding of the similarities and differences in cough…

Detection of sentinel lymph nodes in laryngeal cancer by injection of 99mTc-nanocolloid via flexible laryngoscopy as a new technique

Primary Objective: The feasibility of injecting 99mTc-nanocolloid via a flexible laryngoscope with a working channel and subsequent detection of SLN will be evaluated.Secondary Objective: Preoperative located SLN via gamma camera imaging will be…

Clinical validation of transrectal multiparametric ultrasound imaging strategy (PCaVision) for the detection of clinically significant prostate cancer: a head-to-head comparison with the MRI-based strategy

• The primary objective is to demonstrate non-inferiority of the detection rate of clinically significant prostate cancer (defined as GG >= 2) in targeted biopsies based on PCaVision imaging (PCaVision pathway) in comparison with the…

Goal directed fluid removal with furosemide in intensive care patients with fluid overload - A randomised, blinded, placebo-controlled trial

This study has been transitioned to CTIS with ID 2024-512186-14-00 check the CTIS register for the current data. To assess benefits and harms of goal directed fluid removal with furosemide versus placebo on patient-important outcome measures in…

EXPLORE-SFN Diagnostics: EXtensive Patient LOngitudinal data REgistry for Small Fiber Neuropathy Diagnostics

The primary objective is to gain information regarding the natural course of SFN and the change over time of the diagnostics using clinimetrically sound outcome measures representing various levels of outcome assessment. The secondary objective is…

Imlifidase treatment for acute inflammation in AQP4-IgG associated neuromyelitis optica spectrum disorder

To analyse in what proportion of NMOSD patients with an episode of acute inflammation circulating pathogenic anti-AQP4 IgG antibodies are depleted below detection limits, as measured with a state-of-the-arts cell-based assay, in the timeframe within…

Verb processing and word learning in DLD: Diagnostic tests and neural correlates

The objectives of the proposed research are: (1) to characterize the neural correlates of verbal learning abilities (both for nouns and verbs) in typically developing (TD) children compared to children with DLD, aged 8-12 years old. (2) to…

Refraining from closed reduction of dislocated distal radius fractures in the emergency department

The aim of this trial is to determine if CR in patients with a displaced DRF can be safely abandoned before the plaster cast, as a bridge to surgery, is applied. This could prevent a painful and traumatizing experience and therefore benefit the…

A single dose two-way cross-over study in healthy participants to compare the pharmacokinetics (PK) of salbutamol administered via metered dose inhalers containing propellants HFA-152a and HFA 134a

Certain drugs are administered by using an inhaler (puffs). An inhaler may contain propellant to get the right amount of the medicine into the lungs in the right way. Some of the propellants used in inhalers are greenhouse gasses and are therefore…

Primary percutaneous stenting above the ampulla versus endoscopic drainage
for unresectable malignant hilar biliary obstruction.

To compare the efficacy of PPS above the ampulla to standard EBD in patients with MHBO who are ineligible for surgical resection.

OPEN LABEL PHASE 2 BASKET TRIAL WITH ATEZOLIZUMAB AND TIRAGOLUMAB IN SOLID TUMORS: TIRACAN

This study has been transitioned to CTIS with ID 2024-512616-21-00 check the CTIS register for the current data. The main objective of the trial is to determine the pathological response rate in cohort 1 and the radiological response rates in cohort…

DEnosumab for the treatment of FIbrous Dysplasia/McCune-Albright Syndrome in adults (DeFiD): a randomized double-blind placebo-controlled trial

This study has been transitioned to CTIS with ID 2024-511090-30-00 check the CTIS register for the current data. To investigate whether 3 monthly Dmab will improve the clinical, radiological and biochemical manifestations of FD bone lesions.

A Global, Phase 3, Randomized, Multicenter, Open-Label Study to Investigate the Efficacy and Safety of Furmonertinib Compared to Platinum-Based Chemotherapy as First-Line Treatment for Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer with Epidermal Growth Factor Receptor Exon 20 Insertion Mutations

This study has been transitioned to CTIS with ID 2022-502977-41-00 check the CTIS register for the current data. Primary ObjectiveTo assess the efficacy of furmonertinib compared to platinum-based chemotherapy using progression-free survival (PFS)…