226 results
To assess muscle protein synthesis rates to continuous, elevated plasma amino acid availability in healthy young males
To establish whether the decrease in pulmonary function as a result of wearing a neoprene suit is caused by restriction or obstruction, and which effect is has on pulmonary volumes.
Primary: To describe shoulder function, local fatigue and pain symptoms around the shoulders in children with FSHD type 1, before and after balanced shoulder therapy. Secondary: To gain insight into the experience of children and parents and the…
The primary purpose of this study is to enhance the understanding of the disease progression in sepsis, particularly from ICU admission to the development of DIC. This will be achieved by investigating the association between various biomarkers with…
Primary Objective: To investigate motor developmental outcome at school age of children with CHD compared to typically developing peers.Secondary Objective(s): - To investigate neurodevelopmental outcom eat school age on several developmental…
Primary Objective: • To determine the clinical Progression Free Survival (cPFS) in our study cohort of patients with mCRPC and 68Ga-PSMA-PET/CT selected bone-only disease (PET-bone only group). The cPFS will be compared to the cPFS of patients with…
The objective of the study is to assess the effect of music on postictal agitation when played peri-interventionally for patients undergoing electroconvulsive therapy for severe depression.
The primary aim of this study is to assess the feasibility of EM-navigation for percutaneous liver ablation.
To enhance our knowledge of the molecular nature, induction and regulation of the autoantibody and B cell response involved in/responsible for the induction of VITT
Gain insight into the health and health-related factors in adults with intellectual disabilities.
Primary objective: Development of a normal tissue complication probability (NTCP) model for hypothalamic dysfunction (for severe hypothalamic dysfunction, named hypothalamic syndrome) in childhood brain tumor survivors, incorporating cranial…
The main objective of this study is to determine the maximum tolerated dose (MTD) of 2-fraction boost MRI-guided radiotherapy (MRgRT) for patients with SCC following CROSS therapy. The secondary objectives are feasibility, non-dose limiting toxicity…
This study aims to determine feasibility of providing and following ICU discharged patient with smart technology for 3 months after hospital discharge from a general ward of the Leiden UniversityMedical Centre. If proven successful, home monitoring…
The ultimate goal is to investigate whether aVNS can enhance cortical plasticity and improve functional outcomes during intensive rehabilitation programs in children with cerebral palsy. First, we aim to establish the extent of cortical plasticity…
Primary objectives:• To characterize the central inflammatory response to IV LPS by measuring biomarkers in CSF• To characterize the systemic inflammatory response to IV LPS by measuring biomarkers in blood • Characterize CSF/Blood ratios for each…
Our objective is to design and evaluate proof-of-concept of the WalkWell Gait reTrainer, an affordable, user-friendly continuous gait feedback system, complete with remote patient monitoring capabilities to support clinical care. We hypothesize that…
Primary objective: 1. To validate the data quality and diagnostic accuracy of StrokePointer to detect LVO stroke among patients with a suspected stroke in the pre-hospital setting. Secondary objectives:1. To determine the user-friendliness of…
The primary objective is to investigate the concordance between the Endosign test and EGD by an expert endoscopist for detecting dysplasia and/or EAC in a high-risk category of ULSBE patients. Secondary objectives are to determine the acceptability…
Current laboratory tests for hypersensitivity are not sensitive of do not exist for certain allergens omong which medical drugs. To objective is therefore to optimize existing in vitro tests (lymphocyte activation and proliferation test, cytokine…
To investigate oxidative stress levels in the plasma and urine of late preterm and term newborns treated for PPHN in the NICU.