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Doppler Modifications in Intrauterine Growth Restricted Fetuses

Primary Objective: To assess the hemodynamical effects of administration of AS in FGR fetuses and to compare these effects with those that occur in appropriate for gestational age (AGA) fetuses. Secondary Objective(s): To investigate the effect of…

Modulation of deep cortical regions by means of low intensity transcranial focused ultrasound (tFUS) neuromodulation

Measuring tFUS-dependent changes in behaviour (in our target tasks) when targeting deep brain regions [Behavioral Objective]

A Phase 1 Open-label, Multicenter Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of HBM4003 in Subjects with Advanced Solid Tumors

Part 1: Dose-Escalation Stage (not in The Netherlands)Primary objective:* Safety and tolerability of HBM4003Secondary objectives:* Preliminary anti-tumor activities of HBM4003 in advanced solid tumors* Pharmacokinetics (PK) of HBM4003Other…

Response to a foot muscle strengthening program in a man of ~85 years with intrinsic foot muscle atrophy

The aim of this study is to investigate the extent to which changes are observed in a physically active man, aged around 85 years in 1) PIFMs* size, 2) dynamic balance and 3) foot function during gait after participating in a PIFM strengthening…

Evaluating an educational care pathway supported by smart technology and self-monitoring for patients with type 2 diabetes in a tertiary endocrinology setting

The primary aim of this study is to examine the feasibility, usability, and acceptability of the educational care pathway for both patients and healthcare professionals. The secondary aim is to investigate the preliminary effects on patients*…

A prospective, lead-in study to collect bleeding episodes, Factor VIII (FVIII) infusions, and patient-reported outcomes in patients with hemophilia A

This is a so-called *lead-in study* in which patients receive their standard treatment and no study treatment. The researchers will collect dataabout the patients* bleeding episodes, FVIII containing treatments used to prevent bleeding episodes and…

An Initial Evaluation of the Carillon Mitral Contour System for Treatment of Atrial Functional Mitral Regurgitation

The objective of this prospective, multi-center trial is to assess the effectiveness of the Carillon Mitral Contour System in treating patients with moderate-to-severe atrial functional mitral regurgitation (aFMR).

Intra-articular injection of adipose-derived stromal vascular fraction in osteoarthritis of the temporomandibular joint

The main objective of this study is to test the hypothesis that SVF alleviates pain and increases maximal interincisal mouth opening in patients with TMJ osteoarthritis.

TRANSITIONS IN GOUT RESEARCH STUDY

The aim of this study is to figure out which factors can predict the development of gout, in addition to hyperuricemia.

A multi-center, randomized, double-blind, placebo controlled study of ligelizumab (QGE031) in the treatment of Chronic Inducible Urticaria (CINDU) in adolescents and adults inadequately controlled by H1-antihistamines

The purpose of this study is to establish efficacy and safety of ligelizumab (QGE031) versus placebo in participants with chronic inducible urticaria who remain symptomatic despite treatment with H1 antihistamine.

RESPIRE - A Randomized, Double-Blind, Placebo-Controlled, Multi-Centre Clinical Trial to Evaluate the Safety and Efficacy of ATR-002 in Adult Hospitalized Patients with COVID-19

• To demonstrate the efficacy of ATR-002 versus placebo in addition to standard of care based on the clinical severity status in adult hospitalized patients with COVID-19• To show that ATR-002 in addition to standard of care shortens the time to…

The effect of robotic enhanced error training on upper limb function in people after stroke - a randomized controlled study

This study will investigate whether robotic enhanced error training as adjunct to usual care is beneficial for improving arm function in people after stroke.

Focal Pain Outcomes using Configurations Applied for Lateral Stimulation

To evaluate Multiple Independent Current Control (MICC) perception and sub-perception based programming at Dorsal Column (DC) targets and Dorsal Root (DR) targets for focal foot, knee, or groin pain relief.

Further determining the possible association of skin irritation threshold and hypertrophic scar formation

Objective: The main objective of our study is to examine whether we can use the IT (as determined by visual irritation grading scale after SLS patch test) to predict HS formation after reduction mammaplasties. The secondary objectives consist of…

Multi Country Study to Evaluate Patient Satisfaction for Non-Invasive Fat Reduction in Abdomen, Flanks, Upper Arms, Inner Thighs, Outer Thighs and Submental Area (NuCOOL)

To evaluate participant satisfaction and effectiveness of the CoolSculpting Elite System using CoolSculpting Elite applicators for non-invasive subcutaneous fat reduction of the abdomen and flanks, upper arms, inner thighs, outer thighs and…

A Phase 2, Randomized Placebo-Controlled, Double-Masked Study to Assess Safety and Efficacy of Multiple doses of IONIS-FB-LRX, an Antisense Inhibitor of Complement Factor B, in Patients with Geographic Atrophy Secondary to Age-Related Macular Degeneration (AMD)

To evaluate the effect of ISIS 696844 on the rate of change of the area of GA secondary to AMD measured by fundus autofluorescence (FAF)

A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABBV-154 in Subjects with Moderately to Severely Active Rheumatoid Arthritis with Inadequate Response to Biologic and/or Targeted Synthetic Disease-Modifying Anti-Rheumatic Drugs (b/tsDMARDs)

To assess the safety, tolerability, and efficacy of ABBV-154 administered every other week (eow) and every 4 weeks (e4w) subcutaneously (SC) vs placebo in subjects with moderately to severely active RA with inadequate response to at least one prior…

Functional gait training as complementary treatment to botulinum toxin type A in patients with disabling dystonia due to Parkinson*s disease: a double-blind randomized controlled clinical trial.

To investigate whether treatment of dystonia causing varus tilt of the hindfoot in Parkinson*s disease is more effective when botulinum toxin type A is combined with complementary functional gait training compared to botulinum toxin type A treatment…

"Convenient diagnosis of gestational diabetes";Using Continuous Glucose Measurement as an alternative to the golden standard Oral Glucose Tolerance Test (OGTT).

The main goal of this study is to determine whether the CGM can replace venipunctures to measure blood glucose values during the oGTT.The second goal of this study is to investigate to what extent glucose profiles, measured at home using the CGM,…

Radiofrequency therapy at 448 kHz for persisting pain after episiotomy * a pilot study

To evaluate the pain reducing effect of MCRRF therapy in women with persisting perineal pain after episiotomy using Visual Analogue Scale (VAS) scores.