155 results
This study has been transitioned to CTIS with ID 2024-513843-10-00 check the CTIS register for the current data. Primary objective: Assess the short term safety and tolerability of 68Ga-SATO in pediatric patients with NBLSecondary objectives: -…
1. To determine the prevalence of cam morphology in a sample of professional female football players.2. To determine the prevalence of other hip related radiological features (e.g. neck-shaft angle, epiphyseal extension, lateral centre edge angle…
This study has been transitioned to CTIS with ID 2023-509276-42-00 check the CTIS register for the current data. Primary:To assess the long-term safety of treatment with dabrafenib, trametinib or the combination.Secondary:To assess the long-term…
This study has been transitioned to CTIS with ID 2023-505835-11-00 check the CTIS register for the current data. PrimaryTo demonstrate the superiority of galcanezumab versus placebo in the prevention of migraine in an adolescent population (12 to 17…
1) Assess the whole genome sequence (WGS) and clinical profile of the MPX families to identify how rare and common genetic variants interact to produce shared versus distinct NDDs and clinical features in individuals, or different combinations of…
Individualized trajectories of upper arm disease progression in Duchenne muscular dystrophy patients
Main objective1. To assess the longitudinal trajectories of upper arm flexor muscle MRI parameters, muscle force and upper arm function in a cohort of ambulant and non-ambulant DMD patients, to assess the value of this muscle as target for…
Clinical safety study on 5-Aminolevulinic acid (5-ALA) in children and adolescents with brain tumors
This study has been transitioned to CTIS with ID 2024-517575-20-00 check the CTIS register for the current data. This study proposes a safety study in children in which tumors are operated on using fluorescence-guided resection which are similar to…
The aim of this study is to measure eCAPs intraoperatively (and perform electrocochleography [ECochG] in case of any residual hearing) and to estimate cochlear health in these patients by applying insights gained from our guinea pig experiments.
This study has been transitioned to CTIS with ID 2024-516153-52-00 check the CTIS register for the current data. Primary objective: To demonstrate efficacy of emapalumab in the treatment of patients in:• Cohort 1: Macrophage activation syndrome (MAS…
The primary objective is to develop a disease model predicting clinical meaningful changes based on a combination of results of tests on clinical function, muscle MRI, echocardiography and circulating biomarkers applicable in various stages of…
Primary Objective: We aim to provide a clear phenotype of the immune system in patients with FOXP1 syndrome. Secondary Objectives:We aim to correlate the immunophenotype of patients with FOXP1 syndrome with frequency and type of infections reported…
To investigate whether VR-VOICES is more effective than regular treatment for voicehearing in patients with auditory hallucinations.
The primary aim of this RCT is to evaluate whether the use of oral supplementation of hydrolysed collagen/vitamin C in addition to usual care (education, load management and PTLE) is superior to usual care and placebo on VISA-P score after 24 weeks…
The aim of the current project is to test the clinical and cost-effectiveness of GST for patients with an ED (i.e., anorexia nervosa, bulimia nervosa, other specified), that are not likely to benefit from CBT-E. The study will focus on those…
Primary:- To evaluate the effect of suvratoxumab on reducing the incidence of nosocomial all-cause pneumonia.Secondary:- To evaluate the safety of a single IV dose of suvratoxumab.- To evaluate the effect of suvratoxumab on reducing the incidence of…
To investigate the effect of Bifidobacterium lactis CECT 8145 BPL1® on the seroconversion rate after influenza vaccination in healthy adults, compared to placebo treatment.
Assess the potential efficay of L-serine dietary supplementation in patients children with a GRIN2B LoS mutation.
To assess the early predictive value of IUS for therapy response in children with IBD (new onset or known IBD).
The general aim for this project would be to understand the neurodevelopmental differences with respect to implicit and explicit forms of threat regulation, by focusing on brain development, sex-steroid hormones and social sensitivity in adolescents…
The primary objective is to examine relationships between neurocognitive performance and MRI parameters of brain vasculature, metabolism, and white matter diffusion in children who have been treated for posterior fossa tumor. Secondary objectives…