19 results
The aims of this study are [1]. to investigate the flow hemodynamics through the foramen ovale (FO) directly after birth and [2]. to assess how these changes are influenced by breathing and the timing of umbilical cord clamping in healthy term…
The goal of this research project comprises two important components1) To determine the motor unit number from the CMAP scan at time of diagnosis correlates with treatment efficacy2) To establish the usefulness of the changes in motor unit number…
A pilot study to understand the transmission dynamics of RSV in households and potential reduction of viral transmission.
The objectives of the study are to:A. Determine the effects of music therapy during skin-breaking procedures on the pain response in infants admitted to a NICU or HC ward.B. Determine the effects of music therapy during skin-breaking procedures on…
The goal is to study the genetic background of childhood glaucoma in the Netherlands. We aim to study which mutations play a role in the pathogenesis of childhood glaucoma in the Netherlands and their prevalence. We will study the genetic mutations…
The objective of this study is to determine the ability of respiratory EMG measurements with a wearable to correlate respiratoryimprovement or deterioration in hospitalised children with respiratory disease.
This study aims to investigate whether the intraoperative use of indocyanine green fluorescence angiography (ICG-FA) is feasible and safe in neonates. Feasibility is therein defined as practically possible use of ICG-FA, resulting in clear and…
Therapeutic nadroparin administration:Primary objective: To develop evidence-based dosing regimens of nadroparin for extremely premature, premature and term neonates by means of the objectification of the PK/PD of nadroparin.Secondary objective: 1)…
Primary Objective:To investigate efficacy and adverse effects of AP treatment for pregnant women with SMI.Aim 1a: Efficacy of AP treatment for pregnant women with SMI. Hypothesis: Women taking either APs or non-AP mood stabilizers will be less…
We will assess safety (potential adverse events related to phototherapy using Jauni, e.g. skin injuries, hyperthermia, or hypothermia) and effectiveness (e.g. rate of lowering of bilirubin levels, duration of phototherapy need) of phototherapy using…
The aim of SPIRIT is to investigate the mechanisms of the immunological tolerance to FVIII in patients with hemophilia A aged younger than 18 years using NFT for prophylaxis.
To characterize the natural history of exocrine pancreatic function as measured by FE-1 in infants with CF <12 months of age
Primary objective• To characterise natural disease progression rates of MRI- and/or US-assessed measures of muscle properties and muscle function and strength tests in children with neuromuscular disorders through standardized annual follow-up…
The overarching objective of this master protocol is to study the risk factors (personal, clinical and lifestyle factors) for-, and consequences of- , changes of nutritional status (both over- and undernutrition) in children with cancer. Based on…
Primary Endpoint: Feasibility of including patients in the study, randomization and delivery of the intervention. To assess the primary endpoint, we will examine the probability that: (1) a screened patient is eligible; (2) an eligible patient…
The aim of this study is to evaluate if a PPT can significantly decrease - or possibly prevent - the collapse of the trachea in newborns with EA and moderate or severe TM. Additionally, the study aims to determine whether the observed effect of PPT…
The aim of this study is to establish the accuracy of Molecular Culture for prediciting the outcome of the traditional blood culture.
Primary objective: determine whether HAPTOS intervention results in earlier attainment (postnatal days) of full enteral feeding and/or full oral feeding (postmenstrual age) compared to standard care. Secondary objectives: To determine whether Haptos…
Specific Aim 1) To identify the frequency and risk factors for PVA and its subtypes in ventilated children, with a specific focus on DC breaths. Hypothesis: PVA subtypes related to inadequate ventilator support (flow undershoot and premature cycling…