Search for a trial

EMDR with traumatized adolescents with a major depressive disorder

The aim of this study is to investigate the effectiveness of EMDR with traumatized adolescents (12-18 years) with major depressive disorder.

Measuring the Activated Clotting Time in patients receiving unfractionated heparin prior to coronary angiography and intervention. A single-centre validation study comparing different blood sampling sites

This study aims at establishing the influence of sampling site on the variability of ACT measurement at the end of coronary angiography or PCI.

Monitoring lung fluid clearance and aeration during pulmonary transition after birth

The objective of this study is to obtain physiological data on lung aeration during pulmonary transition in newborn infants.

A phase 1 open-label study to characterize the metabolism and excretion of a single dose of radiolabeled AL-335 administered in combination with Odalasvir and Simeprevir and administered alone in healthy male subjects

The purpose of the study is to investigate how quickly and to what extent AL-335 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). AL-335 to be administered will be labeled with 14-…

Mesalamine for Colorectal Cancer Prevention Program in Lynch syndrome

Primairy Objective* To test whether 5-ASA reduces the occurrence of colonic benign or malignant neoplasia compared to placebo in Lynch syndrome (LS) patients as detected by any colonoscopy until the end of study.Secondary Objectives* To test wheter…

SUCCESS STUDY; Smoking reduction by a smoking cessation strategy in the national cervical cancer screening program

We hypothesize that a smoking cessation strategy for smoking cervical cancer screening participants will increase their motivation to quit and will lead to an increased proportion of smokers performing a serious quit attempt. Eventually this will…

Intra-articular injection of stromal vascular fraction from adipose tissue in osteoartritis of the temporomandibular joint

The main objective is to objectify if the injection of SVF influences the pain of the TMJ during movement. Secondary objectives are pain during rest, maximum mouth opening, and function evaluation.

SSRI's during pregnancy and lactation. Individualized care with drug analysis: Measurements of antidepressants In the Neonate anD breast milk.

With this research project we will investigate the relationship between SSRI concentration in the (pre)term neonate and clinical short and long term effects on the neonate after exposure to SSRI*s during pregnancy and lactation. Furthermore, the…

Feasibility study of ANEUFIX : a novel, first in man approach to treat Type II Endoleaks using ACP-T5.

The primary objective of the study is to assess the feasibility to treat type II endoleaks with Aneufix ACP-T5 successfully.The secondary objectives of the study are to assess the:- Clinical success rate defined as Occurrence of adverse events and…

Mandibular Advancement Device (MAD) therapy in edentulous patients with obstructive sleep apnea: dental implant fixed MADs vs. CPAP.

The main purpose of this pilot study is to assess the feasibility and potential efficacy of implant retained mandibular advancement device (MAD) therapy on a small scale in edentulous patients with mild to moderate OSA in comparison to CPAP therapy…

A randomized controlled trial evaluating the additional effect of topical coal tar to a topical corticosteroid regimen in patients aged >16 years of age with moderate-severe atopic dermatitis

To evaluate the additional effect of coal tar treatment to a corticosteroid regimen in adults (aged >16 years of age) with moderate to severe atopic dermatitis, based on the percentage change in Eczema Area and Severity Index (EASI) at week 2…

Validation in healthy volunteers of a patented lactate probe designed for continuous intrapartum fetal monitoring of lactate levels

Primary Objective: to determine if lactate can be continuously and reliably measured by microdialysis in subcutaneous tissue in healthy volunteers

Efficacy of vitamin D supplementation in preventing peripheral neuropathy in multiple myeloma patients.

The primary objective of this study is to determine the efficacy of vitamin D supplementation on the severity of PN in patients with multiple myeloma.

An Open-label Trial Investigating the Association Between Nocturia Symptoms and Sleep During 12 Weeks of Treatment with desmopressin ODT for Nocturia due to Nocturnal Polyuria in Adults

Primary Objective* To assess the association between changes in the number of nocturnal voids and change in Nocturia Sleep Quality Scale (NSQS) total score in adult subjects with nocturia due to Nocturnal Polyuria (NP)Secondary Objectives* To assess…

Low Level Laser therapy in non-allergic rhinitis: a pilot study

The main objective of this pilot study is to evaluate feasibility, experienced effects and side effects of LLLT, in relation to the administered dose to be able to detect an appropriate dose (intensity of laser) in patients with non-allergic…

Effects of an afternoon stroll under different light conditions on alertness, sleep quality and -perception

To investigate whether three hours of consecutive daylight and activity can affect alertness and improve night-time objective and subjective sleep.

Pilot study to determine clock-related nonvisual effects of light on alertness and metabolism

To test whether a short FD protocol can be used to test whether effects of light on alertness, sleep, metabolism and temperature are under circadian control.

Tight control in the vascular endotype of systemic sclerosis.
Improving outcomes in pulmonary arterial hypertension associated with systemic sclerosis using personalized medicine, a predictive study.

Specific objectives:* To analyse the predictive value of the presence of anti-ETaR, anti-AT1R and a reduction in capillary density, for the development of PAH in patients with SSc, alone and in combination.* To analyse whether anti-ETaR, anti-AT1R…

REduction or eLimination of mItral rEgurgitation in degenerative or Functional mitral regurgitation with the CardiAQ-Edwards* Transcatheter Mitral Valve

The objectives of this study are to evaluate the safety and performance of the valve and delivery systems for the treatment of symptomatic moderate to severe degenerative or functional mitral regurgitation in a prohibitively high risk patient…

Screening of coeliac disease in the Preventive Youth Health Care Centres in the Netherlands

The aim of our project is to perform a novel mass screening to detect CD in 12 months-4 years old children who visit the YHCCs in a well-described region in the Netherlands, to show that it is feasible, efficient, cost-effective and well accepted by…