1267 results
To investigate whether a very early start of EN (< 24 hrs after admission), as compared to selective delayed EN (> 72 hrs), will lead to a lower rate of infectious complications and mortality in patients with predicted severe AP.
The effect of a specially developed multispecies probiotic on visceral perception, as well as on general symptom scores and inflammatory and microbiological parameters will be studied in a pilot study of IBS patients with an increased visceral…
The objectives of this study are to gain new insights on [1] the cause of a higher clopidogrel resistance in DMII patients[2] the increased production of tissue factor in monocytes in DMII patients
To evaluate the efficacy of Lanreotide Autogel 120 mg when used as primary medical treatment in untreated de novo acromegalic patients with macroadenoma
To evaluate the safety and tolerability of a single subcutaneous (s.c.) injection of ISIS 388626 administered at four increasing dose levels (50, 100, 200, 400 mg) and to evaluate the safety and tolerability of multiple doses of ISIS 388626…
The objective of this study is to assess whether sitagliptin may prevent prednisolone-induced impairment of glucose metabolism and beta-cell function.
Within WP6 of a EU Seventh Framework project, we will investigate associations between purinergic receptor SNPs and osteoporosis risk in humans. Genetic data from a fracture cohort in The Netherlands with high prevalence of osteoporosis will be…
The objective of this study is to determine the accuracy of the sentinel lymph node biopsy in multicentric breast cancer prospectively and multi-institutional.
zie K1
Determinination of the added effects of dietary sodium restriction or diuretic use to antihypertensive and antialbuminuric therapy.
Primary objective:To compare the immunological response to vaccination with HPV16 E6 and E7 synthetic long peptides with concomitant application of imiquimod at the vaccination site with vaccination without the concomitant application of imiquimod.…
The purpose of this phase I/II is to characterize the safety, tolerability, preliminary activity, pharmacokinetic (PK) and pharmacodynamics (PD) profile of TKI258 administered orally on a 5 days on/2 days off dosing schedule in adult patients with…
To evaluate the efficacy of the dose level/regimen(s) of RAD001recommended from the phase I with HT therapy. This will bebased on the evaluation of overall response rate according toRECIST [Post-Text Supplement 1].
The primary objective is to determine if intra-articular etanercept therapy reduces the clinical signs and symptoms of inflammatory arthritis and improve outcome (beneficial effect). The secondary objective is to study safety and to analyse…
The study will assess the hypothesis that the combination warfarin & clopidogrel 75 mg/day is superior to triple therapy (warfarin + clopidogrel 75mg/day + aspirin 80mg/day) with respect to bleeding complications while equally safe with…
To predict the risk of particular coronary plaques to cause myocardial infarction
GBM is difficult to treat, due to the fact that tumor cells can move until several centimeters in the brain around the visible tumor location. these infiltrated cellscan not be removed by surgery and are resistant to chemotherapy and radiation. This…
STUDY OBJECTIVESPrimary objectiveTo assess the safety, tolerability and local tolerance of two different intravenous infusion doses over 72 hours of a new dosing regimen and a new formulation of MCI-186 in subjects with acute ischemic stroke.…
primary aim of the study To investigate the efficacy of PEP-223/CoVaccine HT in decreasing serum testosterone levels to below castrate levels, i.e. to < 2 nmol/l, within 8 weeks after the last of three injectionssecondary aims of the studyTo…
Primary: - What are the effects of gait training with the gait rehabilitation device LOPES on the quality and ability of walking in chronic stroke patients with a stiff-knee gait?- What are the effects of two different training modes in the gait…