6103 results
To investigate whether sodium and potassium mutations are found in a cohort of patients with small fiber neuropathy, painful diabetic neuropathy (versus diabetes patients with no or only minor symptoms) and in patients with breast, ovarium or…
The purpose of this prospective study is to evaluate the value of 18F-FDG PET/CT and CT for preoperative regional N staging of bladder cancer and to verify the results by comparison with histopathological analysis, the gold standard.
The aim of this present diagnostic study is to determine the accuracy by which we can detect residual disease after neoadjuvant chemoradiotherapy.
Primary: Phase I part 1) Assessment of the recommended dosing and schedule for metronomic cyclophosphamide when administered in combination with fixed dose (10 mg) oral everolimus in patients with mRCC with respect to the selective induction of CD4+…
Specific AimsAs reviewed above, childhood anxiety disorders are highly prevalent and debilitating, and there is an urgent need for improvement of current treatment strategies. An innovative, but scarcely examined, treatment option for childhood…
The primary purpose of the study is to determine the efficacy of AZD2281 compared to placebo in serous ovariancancer platinum sensitive patients and in a defined HRD subset.
Primary:To determine the MTD and/or RP2D of BKM120 and MEK162 in combination when administered orally to adult patients with selected advanced solid tumors. Secondary:• To characterize the safety and tolerability of the oral combination of BKM120…
Objectives: 1. To assess the prevalence of pain in elderly with dementia and to study the relationship between the various subtypes of dementia and the presence of specific types of pain(e.g. nociceptive pain, neuropathic pain, and orofacial pain).…
The primary objective of the study is to assess the safety and tolerability of long-term open-label CP-690,550 therapy in subjects with CD.Secondary objectives are to evaluate the effect of CP-690,550 maintenance therapy on clinical remission and on…
The primary objective of this study is to determine the freedom from local failure in patients alive at 1 year
The primary objective of this study is to assess whether the efficacy of ocrelizumab given as two dose regimens of 600 mg (given as 300 mg infusions on days 1 and 15 and 600 mg infusion in the following cycles) or 400 mg (given as 200 mg infusions…
The primary objective of this study is to demonstrate the clinical performance of PRO-Kinetic Energy stent in subjects with atherosclerotic disease of native coronary arteries.
The aim of this project is to investigate the association between clinical and genetic factors and DDAVP response in MHA patients and to determine their relative contributions to the DDAVP response.
The primary objectives for Part 1:-To determine the recommended Phase II dose of RO5424802 to be used in Part 2 of the study-To evaluate the safety and tolerability of 600mg and 900mg doses of RO5424802 administered twice daily to subjects with…
This study investigates the optimal intraoperative treatment algorithm to lower glucose in patients with diabetes mellitus type 2 undergoing non-cardiac surgery, comparing intraoperative glucose-insulin-potassium infusion, insulin bolus regimen and…
In this prospective study we aim to find out whether an early refeeding strategy in addition to standard care can improve maternal and neonatal outcome and reduce hospital stay.
In the current study, we want to demonstrate Rienso uptake in the vessel wall in patients with cardiovascular disease and relate the uptake of Rienso to endothelial permeability.
The primairy objective of this fase II study, is to compare two treatment regimens of vismodegib in two populations of patients with multiple BCC's (patients with Gorlin syndrome and patients who do not have Gorlin syndrome). Primary to assess…
To determine whether early goal-directed therapy, aimed at optimizing cardiac output measured by arterial waveform analysis, improves outcome in high-risk, abdominal surgery.
The project has three main scientific objectives: (1) To investigate how speech processing with CIs affects listeners* mental representations at lexical and sub-lexical levels, as well as the flow of information between these levels; (2) To study…