4094 results
The primary objective of this study is to study the effects of intraoperative dexamethasone administration on postoperative recovery following cardiac surgery.
Escalation PhasePrimary ObjectivesThe primary objectives of this study are to:• Determine the safety and tolerability of oral DCC-2618• Determine a maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of oral DCC-261Secondary…
This study has been transitioned to CTIS with ID 2023-509671-17-00 check the CTIS register for the current data. The primary objective is To evaluate the efficacy, in terms of invasive disease-free survival (IDFS), as defined by the STEEP System,…
To study the effects of gDCA on postprandial GLP-1 secretion, inflammation responses and hyperlipidemia in healthy lean male subjects and male T2D patients. The secondary objectives are to evaluate the effect of gDCA and ezetimibe on cholesterol…
The main objectives of this study are: A) to evaluate the differences between chronic migraine patients, episodic migraine patients an healthy controls with respect to i) pain inhibition, ii) sensory profile and iii) corneal nerve fiber parameters;…
This study has been transitioned to CTIS with ID 2024-511235-10-00 check the CTIS register for the current data. To establish one of three study arms, R-CHOP/R-DHAP followed by ASCT (control arm A), R-CHOP + ibrutinib / R-DHAP followed by ASCT and…
Possibly, outcomes of treatment can be further improved by adding atezolizumab to neoadjuvant chemoradiation. As a first step we aim to know whether the addition of atezolizumab feasible. That is, we want to know how the treatment is tolerated and…
To set up a trial*ready cohort by bringing together 7 European cohorts and 1 US cohortand include new subjects, which together comprise more than 800 subjects with the developmentand validation of innovative assessment instruments and disease…
The purpose of this study is to demonstrate the impact on progression of structural damage in the spine as measured by the mSASSS in patients with AS. Data from this study will be used to support the submission of an AS label extension to include a…
This project will be subdivided into three sections:Part I. Comparison of the ESM vs. SR-BDs and other retrospective questionnaires in the assessment of urological complaints in OAB such as urgency. Part II. Validation of new patient-reported…
The objective of the RAAK study is to collect bloed and joint tissue (cartilage, ligaments and subchondral bone) of patients that undergo a total joint replacement due to a endstage OA. Genomic material (DNA and RNA) will be isolated from both the…
The aim of this research project is to study a large a group of patients with tonic dystonia longitudinally, to accurately describe the phenotype, to investigate the potential underlying mechanisms and to identify possible causes and risk factors.
To demonstrate the safety and effectiveness of the Freedom SOLO heart valve when used to replace a diseased or dysfunctional aortic valve or aortic valve prosthesis. Safety will be determined by survival and complication rates. Echocardiography and…
General objective:To develop or validate a clinical prediction rule for major bleeding in patients on oral anticoagulant therapy (OAT) who have been safely anticoagulated without bleeding or venous thromboembolism (VTE) recurrence for 6 months since…