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At-home yoga for endometriosis-related pain.

What is the effectiveness of at-home yoga-intervention for women suffering from pain due to endometriosis when compared to no yoga intervention.

Early detection of diastolic dysfunction and heart failure with preserved ejection fraction

Which markers and which vascular calcifications can be used as diagnostic markers in the dectecion of heart failure with preserved ejection fraction and diastolic dysfunction.

A Randomized, Controlled Phase 3 Study of Cabozantinib (XL184) in Combination with Atezolizumab versus Sorafenib in Subjects with Advanced Hepatocellular Carcinoma Who Have Not Received Previous Systemic Anticancer Therapy

The primary objective of this study is to evaluate the efficacy of cabozantinib in combination with atezolizumab versus sorafenib in subjects with advanced HCC who have not received previous systemic anticancer therapy. An secondary objective is to…

The effects of plant sterol and plant stanol ester enriched foods on liver inflammation in subjects at risk to develop NASH

To assess the effect of consuming plant sterol or plant stanol esters (3 grams/day) for 6 months on ALT concentrations in subjects with elevated ALT concentrations, i.e. who are at risk to develop NASH.

Motivational coaching to improve physical activity behaviour following a supervised 10-week exercise rehabilitation program in cancer patients

The main objective of this study is to examine the effect of motivational coaching following oncological rehabilitation in cancer patients, on minutes of moderate- to- vigorous physical activity (MVPA) measured after six months, with an…

New optical techniques in interstitial lung disease

To identify and define ILD characteristics with innovative imaging by confocal laser endomicroscopy (CLE), optical coherence tomography (OCT) and higher harmonic generation microscopy (HHGM)

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial of Nirogacestat
Versus Placebo in Adult Patients with Progressing Desmoid Tumors/Aggressive Fibromatosis
(DT/AF).

Primary:To determine the efficacy (as defined by progression-free survival [PFS]) of nirogacestat in adult participants with progressing DT/AF.Secondary:To evaluate the safety and tolerability of nirogacestat in adult participants with progressing…

Functional Renal Hemodynamics in Patients with and without Renal Artery Stenosis 2

The primary objective of this study is to assess the dynamic range of renal pressure and flow velocity under exercise induced minimal flow and dopamine induced hyperemia. Secondary objectives are to assess intra-individual variations in the range of…

Prevalence of unmet target LDL-C recommendations in very high risk patients despite high intensity lipid modifying therapy

To assess the prevalence of LDL-C >1.8 mMol/L in a subgroup of very high risk patients with ASCVD, who remain at a very high-residual risk for ACS, despite treatment with high-intensity statins in combination with ezetimibe. This subgroup of…

Phase 2 Active Treatment Study to Evaluate the Efficacy and Safety of SRK 015 in Patients with Later onset Spinal Muscular Atrophy (TOPAZ)

Objectives for both the Treatment Period and Extension Period:Primary Objectives: - To assess safety and tolerability of the study medicine in patients with later onset (e.g., Type 2 and Type 3) spinal muscular atrophy (SMA)- To assess the efficacy…

Oral Fosfomycin versus Ciprofloxacin for Febrile Urinary Tract Infection in Men: a pilot study

To determine the efficacy of oral fosfomycin in comparison to the standard of care oral ciprofloxacin, in the treatment of FUTI after initial empirical treatment with intravenous antibiotics.To describe the pharmokinetic profile of men treated with…

Ultrasound guided resection of tongue and buccal mucosa cancer

In last decades, ultrasound probes have become smaller, which made adequate intraoral ultrasound of oral tumors possible. Therefore, invasion depth is now determined pre-operatively by intraoral ultrasound for staging of oral cancer. Our feasibility…

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, 52-Week Study to Assess the Efficacy and Safety of Etrasimod in Subjects with Moderately to Severely Active Ulcerative Colitis

The primary objective is to assess the efficacy of etrasimod on clinical remission in subjects with moderately to severely active ulcerative colitis (UC) after 12 and 52 weeks of treatment. The secondary objective is to assess the efficacy of…

A 52-Week, open-label, single-arm study to evaluate the safety and tolerability of 24-hour daily exposure of continuous subcutaneous infusion of ABBV-951 in subjects with Parkinson*s disease

To assess the local and systemic safety and tolerability of ABBV-951 delivered as a CSCI for 24 hours daily for up to 52 weeks.

Open-label, Single-arm Trial to Evaluate Antitumor Activity, Safety, and Pharmacokinetics of Isatuximab Used in Combination with Chemotherapy in Pediatric Patients from 28 Days to Less than 18 Years of Age with Relapsed/Refractory B or T Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia in First or Second Relapse.

Primary objective:To evaluate the anti-leukemic activity of isatuximab in combination with standard chemotherapies in pediatric participants of ages 28 days to less than 18 years with Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) or Acute…

Pragmatic randomized controlled multi center trial comparing the effectiveness of antibacterial therapeutic clothing based on silver or chitosan as compared with non-antibacterial therapeutic clothing in patients with moderate to severe atopic dermatitis (AD)

The goal of this study is to assess the effectiveness of antibacterial clothing based on silver or chitosan on the doctor-reported AD severity in patients with moderate to severe AD. Secondary goals are to retrieve information about the effect of…

A Phase 4, Multicenter, 2-part Study Composed of a 1-Year Randomized, Double-blind, Parallel-group, Placebo-controlled, Active-comparator, Dose-optimization Evaluation followed by a 1-Year Open-label Evaluation to Assess the Safety and Efficacy of Guanfacine Hydrochloride Prolonged-release (SPD503) in Children and Adolescents aged 6 to 17 Years with Attention-Deficit/Hyperactivity Disorder

This study has been transitioned to CTIS with ID 2022-502630-71-00 check the CTIS register for the current data. Primary objective: To evaluate the comparative long-term safety of TAK-503 treatment (formerly known as SPD503) in children and…

Phase III Randomized clinical trial for stage III epithelial ovarian cancer randomizing between primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy: OVHIPEC-2

This study has been transitioned to CTIS with ID 2023-509049-11-00 check the CTIS register for the current data. The primary objective of this study is to evaluate the effect of HIPEC on overall survival when added to primary cytoreductive surgery…

Study of pembrolizumab combined with ataluren in Patients with metastatic pMMR and dMMR colorectal cancer adenocarcinomas or metastatic dMMR endometrial carcinoma: the ATAPEMBRO study.

This study has been transitioned to CTIS with ID 2023-509457-31-00 check the CTIS register for the current data. To determine the immune-related progression free survival (irPFS) rate at 21 weeks and objective response rate (irORR) at 30 weeks in…

Dual thrombolytic therapy with mutant pro-urokinase (m-pro-urokinase, HisproUK) and low dose alteplase for ischemic stroke

To test the safety and preliminary efficacy of a dual acute thrombolytic treatment consisting of a small intravenous (IV) bolus of alteplase followed by IV infusion of m-pro-urokinase against usual treatment with IV alteplase in patients presenting…