1555 results
Main Objective: To assess the effects of OCA in patients with PBC on: -Serum alkaline phosphatase (ALP) and total bilirubin, together as a composite endpoint -SafetySecondary Objectives:To assess the effects of OCA in patients with PBC on:-…
To provide UT-15C for eligible subjects who participated in study protocol TDE-PH-310
To evaluate the effects of GH, after final height is reached, on weight, body composition, psychosocial functioning, carbohydrate metabolism and serum lipids. To find an optimal dose growth hormone for adults with PWS. We aimed to stabilize the body…
The goal of this prospective cohort study is to assess fracture union/stability and clinical outcome after surgical and conservative treatments of type II/III odontoid fractures in the elderly patient (>=55 years). The general presumption is…
To study phenotypic and functional characteristics of hepatic lymphocytes in patients with viral hepatitis or other liver related diseases.
Primary Objective: Evaluate the safety of the combination of pomalidomide (POM) and low dose dexamethasone (LD-DEX) in a large cohort of subjects with refractory MM or relapsed and refractory MM.Secondary Objectives:- Analyze the population…
To evaluate to what extent primary headache disorders are caused by genetic factors and to identify genes and pathways involved in the pathophysiology of these disorders.
As of protocol Amendment 06, evaluation of the safety profile of MLN9708 and/or other study medication is the only endpoint being assessed. All other study endpoints will no longer be assessed.
This study will investigates the effect of high dose alkylating chemotherapy compared to standard dose chemotherapy as part of a multimodality approach in patients with oligometastatic HRD positive and/or BRCA1/2 related breast cancer.
The primary objective is overall survival (OS).Secondary objectives are progression free survival (PFS), grade 3 and 4 chemotherapy related toxicity, surgery related morbidity and mortality (30 day and 90 day), quality of life (QoL), number of…
The objective is to gain more insight in:1. Possible causative agents of Kawasaki disease. At the moment no single causative agent has been identified despite the strong suspicion of an infectious etiology of the disease.2. Genetic factors related…
To compare effectiveness, costs and patient preferences in the treatment of sBCC with fractionated 5-ALA 20% PDT versus MAL PDT in 2 sessions.
Primary objective To determine the relation between age and pharmacokinetics of docetaxel, paclitaxel, doxorubicin, gemcitabine, vinorelbine and capecitabine, respectively. Secondary objectives All here cited secondary endpoints will be separately…
To assess toxicity of MRI guided high-dose-rate focal brachytherapy as monotherapy for favourable risk prostate cancer. As secondary objectives, technical feasibility, quality of life and biochemical free survival will be determined.
1- To estimate the prevalence of cardiac abnormalities, defined as systolic dysfunction, cardiovascular risk factors in CCS who have received anthracyclines, mitoxantrone and / or radiotherapy to the heart region compared with sibling controls and…
Primary Objective• To assess the safety and tolerability of long-term tofacitinib therapy in subjects with UC.Secondary Objectives• To evaluate the efficacy of long term tofacitinib therapy in subjects with UC.• To evaluate the effect of long term…
The major objective is to investigate the effects of the GR polymorphisms on metabolism in the skeletal muscle, in order to unravel the pathophysiological mechanisms underlying previously observed clinical effects in carriers of this polymorphisms.…
The International GBS Outcome Study (IGOS) aims to identify the most important clinical and biological determinants of disease progression and recovery in GBS. This information will be used to understand the diversity in clinical presentation and…
Primary objectives:1. To study the development of the infant microbiome, defined as the microbial communities in the nasopharynx (transnasal), oral cavity (saliva), skin and gastro-intestinal tract (faeces), in healthy infants born by vaginal…
This study is intended to collect real-world (post-approval use) data regarding the clinical utility and performance of the Medtronic CoreValve® System for Transcatheter Aortic Valve Implantation (TAVI) in patients with severe symptomatic aortic…