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*MRI protocol development for MR-linac*

To optimize MRI protocols and processing techniques required for MRI guided radiotherapy on the MR-linac measured as signal to noise ratio, contrast, and acquisition time.

Pulmonary artERial hypertenSion: bonE morPHOgeNEtic protein signaling out of control (PERSEPHONE)

Assess BMP10 secretion in patients with pulmonary arterial hypertension and its effect on right ventricular adaptation to pressure overload.

The noradrenergic basis of Parkinson*s tremor: a systems-level fMRI approach

I will test the hypothesis that the noradrenergic system amplifies tremulous activity in the cerebello-thalamo-cortical circuit. More specifically, I will test how this modulation takes place (i.e. through which brain regions and connections).

Randomized open label study to compare the efficacy and safety of everolimus followed by chemotherapy with STZ-5FU upon progression or the reverse sequence, chemotherapy with STZ-5FU followed by everolimus upon progression, in advanced progressive pNETs (SEQTOR study)

The purpose of this study is to compare STZ vs everolimus as first line treatment for advanced pNET and elucidate which sequence of STZ based chemotherapy and the mTOR inhibitor, everolimus, gives better results in terms of PFS in well…

Risk-stratified randomized controlled trial in paediatric Crohn*s Disease: Methotrexate versus azathioprine or adalimumab for maintaining remission in patients at low or at high risk for aggressive disease course, respectively * a treatment strategy

To compare the effectiveness of weekly subcutaneously administered MTX for maintaining relapse-free sustained steroid/EN-free 1-year remission compared with:- daily oral AZA/6MP in low risk paediatric CD- subcutaneously administered adalimumab in…

SHERLOCk: An integrative genomic approach to Solve tHe puzzle of sevERe (earLy-Onset) COPD

The aim of this study is to identify why a subset of COPD patients develops such a severe COPD at early age and with relatively few packyears smoking. This will need a functional genomics approach integrating both whole genome DNA sequencing data in…

A randomized double-blind, placebo-controlled study of LEE011 in combination with letrozole for the treatment of postmenopausal women with hormone receptor positive, HER2-negative, advanced breast cancer who received no prior therapy for advanced disease (CLEE011A2301)

Primary objective: Progression free survival (PFS) of treatment with letrozole plus LEE011 compared to treatment with letrozole plus placebo .Secondary objectives: Overall survival (OS), overall response rate (OR), overall clinical benefit rate,…

A prospective study to evaluate long-term clinical outcomes of the GTS
cementless femoral stem

The objectives of this prospective clinical study are:1. Obtain multi-center, long-term (10-year) clinical data on the new GTS® femoral stem inits standard and lateralized versions2. Collect quality of life data

A NOVEL observational longiTudinal studY on patients with a diagnosis or
suspected diagnosis of asthma and/or COPD to describe patient
characteristics, treatment patterns and the burden of illness over time and
to identify phenotypes and endotypes associated with differential outcomes
that may support future development of personalised treatment strategies

The primary objectives are:*To describe patient characteristics, treatment patterns and the burden of illness over time for individuals in clinical practice with a diagnosis, or suspected diagnosis,2of asthma and/or COPD. Data will be described for…

A Randomized, Double-blind, Placebo-controlled, Adaptive Study to Evaluate Symptom Improvement and Metabolic Control Among Adult Subjects With Symptomatic Hypoparathyroidism Treated With Recombinant Human Parathyroid Hormone [rhPTH(1-84)]

The primary objective is to test the hypothesis that rhPTH(1-84) treatment can result in superior improvements in the symptoms of hypoparathyroidism as assessed by the Hypoparathyroidism Symptom Diary (HPT-SD) symptom subscale compared with standard…

The effect of a gastric bypass on the pharmacokinetics of citalopram

Primary objective: Determine whether a RYGB operation causes a clinically significant decrease in AUC (area under serum concentration-time curve) of citalopram three months after surgery in comparison with the situation before the operation.…

Pharmacogenetics Use For Further treatment Improvement in childreN

To assess whether ADRB2 genotype-guided asthma treatment in children with persistend athma symptoms despite ICS treatment leads to better asthma control compared to non-genotype-guided asthma treatment.

A Phase 3, Randomized, Double-Blind, Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Subjects with Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Non-Biologic Disease Modifying Anti-Rheumatic Drug (DMARD) - SELECT - PsA 1

This is a Phase 3 multicenter study that includes two periods. Period 1 is designed to compare the safety, tolerability, and efficacy of upadacitinib low dose once daily (QD) and high dose B QD versus placebo and versus adalimumab every other week (…

The efficacy of flEcainide Compared To metOprolol in reducing Premature ventrIcular Complexes. An open label cross-over study in pediatric patients.

To test the acute effect of beta-blockers vs flecainide on the reduction of PVCs in a pediatric population. Secondary objectives are to perform a prospective evaluation of the effect of PVCs on LV function, to test the effect of reduction of PVCs by…

A Phase Ia/Ib Open Label, Dose-Escalation study of the Safety and Pharmacokinetics of RO7198457 as a Single Agent and in Combination with Atezolizumab in Patients with Locally Advanced or Metastatic Tumors.

Main Objective (EudraCT):To evaluate the safety and tolerability of RO7198457 when administered as a single agent (Phase [Ph] Ia) or in combination with atezolizumab (Ph Ib), with or without prophylactic treatment with corticosteroids, including…

Multicentre evaluation of the *wait-and-see* policy for good responders after neoadjuvant (chemo)radiation for rectal cancer

The main objective of the study is to provide short and long term oncological and functional outcome data on organ preserving treatment in good responders after a standard indication for neoadjuvant (chemo)radiation. Additional aims are [1] to set…

Predicting Outcome and Disease Course in acquired demyelinating syndromes in childhood

The PROUD-kids 2.0 study aims to find parameters to identify and distinguish between the different subtypes of ADS. Also finding predictive factors for disease course and disease severity. Genetic and environmental factors will be investigated to…

Development of a *two hit* in vivo autologous platelet transfusion model in healthy volunteers

To develop a *two hit* in vivo autologous PLTs transfusion model in healthy male volunteers

Bowman layer transplantation for treatment of corneal contour deformations

To determine whether corneal stabilization can be achieved using a BL onlay and minimize the risk of complications which occur during more invasive techniques. This would also be a technically less demanding surgical procedure.

A Phase 2, multi-center, open label study of NIR178 in combination with PDR001 in patients with selected advanced solid tumors and non-Hodgkin lymphoma (CNIR178X2201)

Primary: • Part 1:To evaluate the efficacy of NIR178 and PDR001 combination in patients with selected advanced solid tumors and diffuse large B cell lymphoma (DLBCL). • Part 2: To assess the efficacy of several intermittent dosing schedules of…