1363 results
High-Volume Image-Guided injections will provide a significant improvement in symptoms compared to Low- Volume Image-Guided injections in patients suffering from chronic midportion Achilles tendinopathy
The primary objective of this study is to obtain clinical proof of principle that the Addition of a PgP/BCRP inhibitor increases CNS concentrations of tyrosine kinase inhibitors by inhibition of drug efflux transporter function in the blood brain…
The individual counselling intervention will significantly
Our hypothesis is that after the intervention the exposure assessment and behavioral factors (e.g. knowledge, skills and social influence) in the intervention group will be significantly higher than the outcomes of those in the control group at…
1) FeNO, blood eosinophils and total IgE will have a moderate diagnostic accuracy to detect sputum eosinophilia in adult-onset asthma patients. 2) There will be differences in accuracy between sub-groups of patients.
Intestinal bacteria have been linked to human metabolism. Animal studies have suggested that the intestinal microbiota product butyrate itself can also affect satiety and improves insulin sensitivity. The question thus remains whether increasing…
Patients who develop single-sided deafness (SSD) become aware of the importance of hearing with two ears in everyday listening environments. Current clinical practice for patients with SSD consists of optimizing hearing using a Bone Conduction…
The aim of this randomised controlled trial is to compare if adding sodium bicarbonate 1.4% to lidocain chloorhydrate 1% and epinifrine 0.9% results in significant less per-and postoperative pain in comparison with the routine LTA epinifrine 0.9%…
Duloxetine is effective as third choice pain medication for treating chronic pain in osteoarthritis patients.
Rock and Water is effective on sexual behaviour and communication of boys aged 14-17 years old.
To investigate the differences in short-chain fatty acid metabolism, markers of local (intestinal) and systemic inflammation and markers of bacterial translocation between type-1-diabetes patients and healthy controls and to relate these differences…
We propose to evaluate the beneficial effects of adding a contingengy management (CM) intervention, aimed at a reduction of cocaine consumption, to the current heroin-assisted treatment. This intervention – combined heroin-assisted treatment plus CM…
We hypothesize that monomeric and oligomeric flavanols (MOF) have a beneficial effect on renal-endothelial function in the dietary management of T2D, as reflected by improvement of AER and renal-endothelial biomarkers.
We will investigate the effects of high dairy intake on metabolic flexibility, glucose metabolism and insulin sensitivity, which are all important characteristics of (metabolic) health. We hypothesize that high dairy intake improves insulin…
Magnetic resonance imaging (MRI) is now the imaging modality of choice for many neurological and musculoskeletal conditions. In the past, implanted cardiac devices including pacemakers (PM) have been contraindicated by MRI scanner, due to the…
There is consensus that an endotracheal intubation procedure should be performed while the infant is adequately sedated. However, whether sedation should be given during the minimal invasive surfactant procedure is still unclear. So far, no studies…
We hypothesize that a reduction of the current radiographic follow-up protocol for patients with ankle and wrist fractures will lead to significant cost savings without compromising quality of care
The aim of the current study is to test whether online training of a positive attentional bias or positive interpretation bias is successful in increasing resilience, reducing internalizing symptoms and preventing clinical disorders (anxiety/…
We hypothesize that daily oral administration of increasing dosages of Eubacterium hallii, an anaerobic intestinal bacterial strain, can exert beneficial effects on insulin sensitivity and liver fat.
1) Tapering of SSRIs with added preventive cognitive therapy (CT) increases the risk of clinically relevant maternal relapse of depression in excess of [absolute] 15% compared to continuation of SSRIs. If rejected, then discontinuation is deemed non…