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Ghrelin concentrations in gestational diabetes.

To compare acylated and unacylated ghrelin concentrations in pregnant women with GD and without GD.

Urinary markers for fetal growth restriction: the role of gaseous vasoactive molecules.

Hypothesis: gaseous signaling molecules influence placental vasomotor activity to compensate for hypoxemia. Metabolites of these vasoactive molecules can be found in the blood and urine and can indicate whether this (compensatory) mechanism is used…

A multicenter randomized controlled trial comparing long term scar quality after hydrosurgical versus conventional tangential excision of deep dermal burns

To assess and compare long term scar quality of deep dermal burns after debridement with hydrosurgical- and conventional tangential excision.

Cortical mechanisms of vestibular influence on hand choice.

The main objective is to investigate the preparatory process in left primary motor cortex in relation to hand choice during whole-body motion.

Effectiveness of a 12-week self-myofascial release therapy on pain and tendon stiffness in active recreational runners with self-reported Achilles tendon complaints

The purpose of this study will be to evaluate and compare the effectiveness of a multifocal SMR treatment on pain and stiffness compared to ECC in active recreational runners with self-reported Achilles tendon complaints.Research question: Is a 12-…

A clinical study to evaluate the safety, tolerability, and pharmacokinetics of the MMP 12 inhibitor FP- 025 after multiple oral ascending dose administration, and to evaluate the effect of food after a single oral dose administration in healthy subjects

Primary* To determine the safety and tolerability of multiple oral ascending doses of FP 025 in healthy subjects.Secondary* To determine the pharmacokinetics (PK) of FP 025 after multiple oral ascending doses of FP 025 in healthy subjects.* To…

HbA1c lowering before surgery in poorly controlled diabetes mellitus; a pilot study

to study the feasibility of lowering HbA1c before elective surgery in patients with suboptimalpoorly controlled DM (HbA1c >7%/53 mmol/mol).

Diaphragm-protective mechanical ventilation in critically ill patients: A proof of concept study.

Primary objective of this study is to assess the feasibility of using a monitoring and a titration algorithm to prevent inactivity and excessive activity of the diaphragm. This will be determined by comparing the fraction of breaths where diaphragm…

APA12/PANTER* study: ""PTM202 and modulation of host resistance to diarrheagenic Escherichia coli in a randomized placebo-controlled trial in healthy human subjects"

To study whether PTM202, a dietary formula containing a proprietary mixture of dried bovine colostrum and dried whole egg, improves the resistance of humans to traveller*s diarrhea as caused by diarrheagenic E. coli. PTM202 contains specific…

A single dose, randomized, four-way cross-over, bioavailability and food interaction study of PedPRM (Pediatric Prolonged Release Melatonin, Neurim Pharmaceuticals Ltd) and Circadin® tablets in healthy male and female volunteers.

Primary Objective- To demonstrate dose proportionality between 1 mg and 5 mg of PedPRM (Neurim Pharmaceuticals Ltd.) following a single oral dose in healthy male and female volunteers (treatment A and C), under fed conditions.Secondary Objectives-…

A Phase I, drug-drug interaction study between oral doses of GLPG1205 and an OCT2 probe substrate (metformin) or a BCRP probe substrate (rosuvastatin) in healthy male subjects

PrimaryTo assess the effect of GLPG1205 on the single dose pharmacokinetics (PK) of an OCT2 probe substrate, metformin, in healthy male subjects.To assess the effect of GLPG1205 on the single dose pharmacokinetics (PK) of a BCRP probe substrate,…

Holmium-166-radioembolization in patients with unresectable hepatocellular carcinoma; a multi-center, interventional, non-randomized, non-comparative, open label, early phase II study: HEPAR Primary

Primary objective:To establish the safety and toxicity profile of 166Ho-RE in patients with hepatocellular carcinoma. Secondary objectives:* To evaluate efficacy of 166Ho-RE in hepatocellular carcinoma without curative treatment options in a non-…

PET for Registration of Inflammation in the Vascular wall of Intracranial
 Aneurysms

To ascertain the hypothesis that T-cell inflammation in the vascular wall of an unruptured intracranial aneurysm can be accurately detected with 18F-IL2 PET (proof-of-concept).

AN OPEN-LABEL, RANDOMIZED, SINGLE DOSE, TWO-TREATMENT (FED VS FASTING), TWO-PERIOD, TWO-SEQUENCE CROSSOVER STUDY TO ASSESS THE EFFECT OF FOOD ON SODIUM OXYBATE FOR EXTENDED RELEASE ORAL SUPENSION (FT218) FORMULATION ADMINISTRERED AT 6 G IN HEALTHY VOLUNTEERS

FT218 is a new formulation (composition) of the registered drug sodium oxybate. Sodium oxybate (also known as the sodium salt of gamma-hydroxybutyric acid [GHB]) is registered under the name Xyrem® for the treatment of narcolepsy (excessive…

Dihydropyrimidine dehydrogenase (DPD) deficiency and haematological abnormalities

To establish whether or not DPD deficient patients suffer from an altered white blood cell homeostasis or function, in particular of B or T lymphocytes.

PARROT-2: Postprandial plasma amino acid concentrations after dairy consumption

To compare postprandial plasma amino acid concentrations over time after ingestion of a fixed amount of protein from different dairy products in healthy adults.

Magnetic Marker Localization for breast cancer surgery: An exploratory study

The purpose of this clinical study is to investigate surgical usability, patient-reported outcomes and effectiveness of the MaMaLoc technique and compare it with WGL.

Brain Train, Cognitive training and physical exercise for older bipolar patients, a pilot study.

Primary objective: evaluation of feasibility of a pilot intervention by measuring adherence to the training program and evaluation of the different aspects by the participants Secondary objective: measuring possible beneficial effects on all domains…

A randomized, double blind, placebo-controlled single ascending dose study on the safety, tolerability, pharmacokinetics and pharmacodynamics of ACT017 in healthy volunteers

PRIMARY OBJECTIVETo evaluate the safety and tolerability of single ascending, intravenous doses of ACT017 administered as a 6-hour intravenous (i.v.) infusionSECONDARY OBJECTIVES* To evaluate the pharmacokinetics of single ascending, intravenous…

A 12-week randomized, patient and investigator blinded, placebo-controlled, parallel group study to investigate the efficacy of LIK066 in obese patients with non-alcoholic steatohepatitis (NASH)

Primary objective:- To determine the effect of LIK066 on Liver Function test after 12 weeks of treatmentSecondary objectives: - To determine the effect of LIK066 on intrahepatic lipid after 12 weeks of treatment- To determine the effect of LIK066 on…