173 results
The primary aim of this study is to examine prospectively the effects of BOOSTH on moderate to vigorous PA (MVPA) in primary school children (5th to 7th grade).
The overall aim of the study is to correlate the anatomical and functional anatomy of the larynx, as seen on MRI to various functional outcome measures in patients who underwent open airway surgery for LTS. The specific aims of this study are: 1) to…
The primary objective of this study is to investigate the neuro-endocrine development of socio-emotional control related to automatic emotional action tendencies, the structural maturation of the brain, and how these contribute to cognitive control…
Primary Objective:To evaluate the efficacy of VX-445 in triple combination (TC) with tezacaftor (TEZ) andivacaftor (IVA) in subjects with cystic fibrosis (CF) who are heterozygous for F508del and aminimal function mutation (F/MF subjects)Secondary…
Primary Objective:To evaluate the efficacy of VX-445 in triple combination (TC) with tezacaftor (TEZ) and ivacaftor (IVA) in subjects with cystic fibrosis (CF) who are homozygous for the F508del mutation (F/F)Secondary Objectives:* To evaluate the…
The goal of the study is to examine whether optimal exposure is more effective than CBT as usual in youth with anxiety disorders. The secondary objective is to investigate whether decreases in harm expectancies are predictive of treatment outcome,…
To determine the effect of mutations in the TBL1X gene on TH dependent signalling in liver cells generated from iPSCs.
The overall aim of this study is to identify developmental deficits in children with Rolandic epilepsy. If developmental deficits are observed, we hope to determine timing, persistence, and prognostic factors for developmental deficits and improve…
To evaluate the natural progression of disease over time in USH1B patients using visual field testing and best corrected visual acuity.
To investigate whether age-related differences in grammar acquisition primarily reflect maturational changes in neural plasticity and pathways that support learning and consolidating of new linguistic knowledge and skills.
The primary objective of the study is to descriptively characterize the single-dose and steadystatePharmacokinetics (PK) of diacerein (if quantifiable) and its active metabolite, rhein, after topical application of CCP-020 (diacerein 1% ointment)…
The purpose of the overall project is to adapt an existing self management tool for adults to the needs of young people and how to implement the adapted app within the youth mental health. The overall project consists of three different phases with…
Objective: The present protocol is nested in the TRACE study (CMO 2014-1349, NL50015.091.14 and in the linked TRACE-BIOME study, CMO 2015-1806, NL53630.091.15), and explores whether an ED, compared to healthy diet, affects the fronto-striatal and…
- What is the echogenicity (quantitative described as z-scores, based on own laboratory values and qualitatively described as Heckmatt gradations) of orofacial muscles (digastrics muscle, geniohyoid muscle, masseter muscle, temporal muscle) in…
In this project we aim to anticipate the need for effective interventions and develop an outreaching systemic intervention for promoting adherence and self-management among adolescent and adult kidney transplant recipients aged from 12 years. The…
Primary objectiveTo evaluate the efficacy of subcutaneous (SC) administration of tralokinumab compared with placebo in treating adolescent subjects (age 12 to <18 years) with moderate-to-severe AD.Secondary objectivesTo evaluate the efficacy…
The primary objective of this project is to map differences in joint loading between athletes receiving visual feedback and those who will not receive visual feedback in both retention and transfer to field-specific situations. From there. we will…
To determine the minimal amount of energy needed to effectively terminate ventricular arrhythmias
Primary Objective:Determine the relevance, feasibility, reliability (test-retest, inter- and intra-rater) and validity of a selected set of outcome measures in children with mitochondrial encephalopathy. Secondary Objective: Determine in- and…
Specific Aim #1: To evaluate the efficacy and safety of shortened-duration (6 weeks total) versus conventional duration (3 months total) anticoagulation for first-episode, provoked, acute venous thrombosis among children in whom thrombus resolution/…