Search for a trial

Can goal directed nutritional support reduce sarcopenia in surgical oesophagus patients?

This study investigates the impact of a goal directed nutritional support protocol on sarcopenia in oncological patients undergoing an esophagectomy and secondary the incidence of anastomotic leakage and pneumonia, surgical infection and lenght of…

The effects of the Dramatherapeutic Self-concept Module: a multiple baseline single-case study on the effects of the Dramatherapeutic Self-esteem Module for patients with a personality disorder, who are indicated for outpatient schemafocused therapy.

Investigating the progress of the self-esteem and well-being before, during and after the Dramatherapeutic Self-Image module in clients with a personality disorder who are in treament phase 1 of outpatient schema focused therapy.Investigating which…

Effectiveness of Somatostatin Analogues in Patients with hereditary hemorrhagic telangiectasia and symptomatic gastrointestinal bleeding, the SAIPAN-trial: a multicenter, randomized, open-label, parallelgroup, superiority trial.

To determine if SSA are effective in decreasing transfusion requirements and improving quality of life while being cost-effective.

Roads to Recovery, control of balance and gait after stroke

The primary objective of this study is to compare the changes in neuromuscular control related to reactive and adaptive movements during balance and gait, following Dynamic C-mill Training to conventional physiotherapy. Furthermore, an additional…

In utero sonographic assessment of calve muscles in fetuses with clubfeet (pes equinovares) and fetuses with no structural anomalies with follow-up after birth.

The primary objective of the study is to examine muscle atrophy in fetuses with single or bilateral IPEV, in comparison to a normal population by measuring the circumference of the upper and lower legs by ultrasound examination. The length of the…

*Feasibility and safety of same day discharge using live video consultation and remote monitoring in a selected group of bariatric patients'

The aim of the study is investigate the feasibility of same day discharge supported by live video consultation and remote monitoring in a selected group of bariatric patients.

Adjustment of insulin Degludec to Reduce post-Exercise (nocturnal) hypoglycaeMia in people with diabetes - the ADREM study

To examine the effect of two different degludec dose adjustments on glucose profiles and the incidence of (nocturnal) hypoglycaemia after oxidative exercise in people with DM1 at elevated risk of hypoglycaemia.

Exploratory Biomarker Study of Fatty Acid profiles in Healthy Volunteers and patients with Parkinson's Disease

- To investigate the baseline profile and inter- and intra-subject within-day and between-day variability of the fatty-acid profiles including fatty-acid desaturation index (FA-DI) and PUFAs in the plasma of patients with Parkinson*s disease and…

Heart failure and Promotion of Physical Activity before and after Cardiac reHabilitation

To investigate in our defined HF patient population if monitoring in combination with motivation on physical activity leads to an increase in enrollment rate for cardiac rehabilitation and sustained physical activity after cardiac rehabilitation as…

A MULTICENTER, OPEN-LABEL, SINGLE ARM STUDY OF OBINUTUZUMAB SHORT DURATION INFUSION (SDI) IN PATIENTS WITH PREVIOUSLY UNTREATED ADVANCED FOLLICULAR LYMPHOMA

This study will evaluate how safe administering obinutuzumab as a short duration infusion (SDI) during cycle 2 and from cycle 2 onwards in combination with chemotherapy in patients with previously untreated advanced FL is.

Randomized, double-blind, placebo-controlled single ascending dose study to investigate the safety, tolerability, pharmacokinetics, pharmacodynamics and food-effects of YTX-7739, a novel oral inhibitor of Stearoyl-CoA-desaturases, in healthy volunteers

* Part A: To investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of increasing doses of YTX-7739 in healthy subjects. * Part B: To study the effect of food on pharmacokinetics of YTX-7739 in a selection of subjects who…

A multicenter, randomized, double-blind, placebo-controlled, crossover trial to evaluate the effects of evolocumab added to standard lipid-lowering therapy on fasting and post fat load lipids in patients with Familial Dysbetalipoproteinemia.

To evaluate the effect of 12 weeks subcutaneous evolocumab (140 mg pre-filled pen every 2 weeks) compared to placebo on post fat load non-HDL-C levels in 30 subjects with FD, in a multicenter, randomized, placebo-controlled, double-blind, crossover…

Effects of oral levosimendan (ODM-109) on respiratory function in patients with ALS: open label extension for patients completing study 3119002

Is to evaluate long-term safety of oral levosimendan in amyotrophic lateral sclerosis (ALS) patients.

An Open-Label Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-JNJ-67856633, a MALT1 inhibitor, After a Single Oral Dose in Healthy Male Participants

In this study we will investigate how quickly and to what extent the new compound JNJ-67856633 is absorbed, transported, and eliminated from the body. JNJ-67856633 is radioactively labelled with carbon-14 (14C).We also investigate how safe JNJ-…

Clinical validation of physical activity measured by the Vital Signs Monitoring System in a controlled environment

The main objective of this study is to validate the accuracy of the device to monitor the physical activity of a subject by comparing the measured values to the golden standard (video recording).

An open-label study to characterize the absorption, distribution, metabolism and elimination of a single oral dose of 14C-leniolisib in healthy male subjects

In this study we will investigate how safe the new compound leniolisib is and how well it is tolerated by healthy male participants.We also investigate how quickly and to what extent leniolisib is absorbed, transported, and eliminated from the body…

An open-label, randomized, single center, crossover study in healthy participants to assess lipoprotein lipase activity and levels, and triglyceride levels after heparin exposure, in both fasted and postprandial state

In this study we will investigate biomarkers in blood after exposure to heparin in the fasted state or after a high-fat meal. Biomarkers are proteins present in the blood. The biomarkers investigated in this study are proteins that are involved in…

Towards HOMe-based Albuminuria Screening: an implementation study testing two approaches

Primary Objective: To investigate whether population screening for increased albuminuria among the Dutch population can contribute to the early detection of yet undiagnosed risk factors for renal and cardiovascular diseases in an early stage. For…

A Two-Part, Open-Label, Single-Dose Relative Bioavailability and Food Effect Study of THB001 in Healthy Adults

Part 1:Primary objective:• To estimate the relative bioavailability of two THB001 formulations in healthy adults.Secondary objectives:• To determine the single-dose pharmacokinetics (PK) of THB001•HCl salt and THB001 free base formulations in…

A Non-Interventional Mechanistic Study to Characterize Biomarkers for Mitochondrial Dysfunction and Inflammation in Subjects with Mitochondrial Disorder and Cardiomyopathy, and Healthy Volunteers

To explore, whether markers of mitochondrial dysfunction measured in isolated PBMCs or immune cell subpopulations differ between subjects with mitochondrial disorders and cardiomyopathy and healthy volunteers.