4117 results
The objective of this study is to investigate of inflammatory tissues of patients with SSj, CLE and SSc contain autoreactive B and T cell expansions that are differently activated compared to other B and T cell expansions in patients with SSj, CLE…
the primary aim is to determine the effect of thawed deep-frozen platelets re-suspended in thawed deep-frozen plasma versus room temperature stored platelets in platelet additive solution for transfusion on the percentage of patients with surgical…
We hypothesize that during an episode of immune-mediated organ specific toxicity, as a result of inflammation and damage to the specific organ, organ-derived DNA will be detectable in blood of patients. The aim of this project is to investigate…
To provide high-quality remote care to patients with type 2 diabetes, using an eHealth platform with support from a medical service center. The present study is optimisation and implementation research. Notably, the aim is not implementation but…
SARS-CoV-2 is related to a number of seasonal coronaviruses that have been endemic in humans for decades and usually cause *common cold* symptoms (HCoVs). Several studies have shown that SARS-CoV-2-specific T-cells can be detected in individuals…
Primary Objective: To investigate whether small size interarcuair decompression is more effective than conventional laminectomy in patients with INC caused by LSS. Secondary Objective(s): To investigate whether small size interarcuair decompression…
The aim of the study is to investigate whether SI-NET's can be visualized with Methylene Blue (MB) and near-infrared (NIR) fluorescence imaging.
This study has been transitioned to CTIS with ID 2024-516738-36-00 check the CTIS register for the current data. The primary purpose of this study is to determine the maximum tolerable dose (MTD) of IP monotherapy with paclitaxel for patients with…
Primary Objective: 1. What is the efficiency of a blended care version of the POWER diet (Blended POWER), compared to the POWER diet used in usual care (usual care POWER program): is Blended POWER equally effective in reducing weight after 1 year in…
The objective in the vanguard phase of the LIMIT trial is to assess the feasibility of recruiting 400 subjects over approximately 3 years at 5 centres. The objectives in the full trial are to evaluate the safety and efficacy of a common, lower INR…
This study has two parts. The main objective of part 1 (in vivo) is todetermine changes in markers of oxidative stress in exhaled breath as a result of different short term oxygenation strategies (liberal versus conservative) . The main objective of…
To test the hypotheses that patients who show severe fatigue after COVID-19 infection exhibit an exaggerated abnormal expression of inflammatory monocyte genes (particularly of the genes involved in pyroptosis, such as IL-1 and IL-6) as compared to…
The primary goal is to assess the survival rate of dental implants placed in cleft patients compared to non-cleft patients. Secondary objectives will be: evaluation of the parameters on the survival of dental implants (smoking, oral hygiene, length…
To determine the factors that contribute to response to CAR T-cell therapy, both at the tumour-end, as well as on the T-cell side to understand mechanisms of efficacy and immune escape in order to optimize this treatment and to reduce toxicity
The objective of this study is to collect additional data on the performance and safety of the slowly-resorbable TIGR® mesh of incisional hernia prevention in patients with AAA undergoing midline laparotomy.
The ultimate goal of the consortium is to use state-of-the-art imaging, genetics, and machine-learning techniques to identify NCCM patients at risk for severe arrhythmia or stroke and guide preventive therapy using personalized risk scores
Objective of the study is to investigate if a mild sensitizing drug (oral capecitabine) combined with a high dose hypofractionated radiation regime to the esophageal region is feasible in this unfit patient group. If feasible, in a consecutive study…