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Continuous versus Intermittent Nutrition in Paediatric Intensive Care: a Proof-of-concept

The main research objectives for the proof-of-concept study are to show the feasibility and safety of a daily cycle of feeding and fasting in critically ill children of different age-groups, that will trigger an adequate fasting response while…

Clinical validation of non-invasive tissue perfusion measurements in Vascular diseased patients with PeriFlux 6000 Enhanced Perfusion and Oxygen Saturation (EPOS) system * Pilot study

This pilot study aims to investigate the feasibility and clinical performance of tissue perfusion measurements with EPOS in the feet/legs in healthy volunteers and patients with PAD. The EPOS system has not yet been CE approved, and has not been…

*Better Exercise and FOod, better REcovery:
*Improving physical functioning and quality of life by preoperative training and nutritional supplementation in older patients undergoing colorectal cancer surgery. A pilot study.'

The aim of this randomized controlled pilot study is to investigate the feasibility and to improve the functional recovery of a patient, by providing them with a multimodal prehabilitation program consisting of supervised physical exercise and/or…

Time to diagnosis of HCV re-infection with the use of a self-test. A feasibility study.

To assess the effectivity and feasibility of HCV RNA self-testing in reducing the time to diagnosis of HCV re-infection in MSM previously cured of an HCV infection, compared to the current diagnostic standard of care. To evaluate whether the uptake…

Analysis of immunological and genetic signatures in pediatric inflammatory bowel diseases

In this study it is aimed to investigate the genetic and immunological causes of VEO-IBD in order to improve diagnostics and therapies for patients with this intractable disease. In an explorative approach, state-of-the-art genome-wide screenings on…

Vibrating socks: a novel cueing intervention to reduce freezing of gait in Parkinson*s disease.

To test the clinical efficacy of vibrating socks, a new tactile cueing device, for the management of FOG in patients with PD.

effect of a higher bloodpressure on Right Ventricular Function

To demonstrate differences in RV function by raising the systemic blood pressure with norepinephrine.

Focused fMRI and Brainstem Evoked Response Audiometry (BERA) to Probe the Brainstem Mechanism in Tinnitus

The main objective of this study is to compare the brainstem sound-evoked response of the subject groups with different hearing loss laterality and with/without tinnitus. These comparisons may let us know if the function of the human brainstem is…

A randomized, placebo-controlled, double-blind, parallel arms study to evaluate the pharmacokinetic and pharmacodynamic relationship of multiple subcutaneous injections of apraglutide in healthy volunteers.

1. A better understanding of the apraglutide dose/concentration-effect relationship;2. A better understanding of duration of effect (apraglutide kinetics in relation to citrulline kinetics).

Neural correlates of trauma-focused psychotherapy in PTSD: A longitudinal fMRI investigation

The current study*s primary aim is to test how trauma-focused therapy affects PTSD symptom-specific neural activity, and investigate neural markers that may predict treatment response to trauma-focused exposure. Furthermore, it is expected that…

Effect of sodium oxybate on brown adipose tissue activity in narcolepsy

Primary objective:1. To assess the effect of SXB treatment on cold-induced BAT volume and activity in narcolepsy type 1 patients.Secondary objectives:1. To assess the effect of SXB treatment on thermoneutral BAT volume and fat fraction, lipoprotein…

A randomized, double-blind, placebo-controlled, multicenter, phase 2a study to evaluate the safety, tolerability, and early proof of concept of TAK-018 for the prevention of postoperative Crohn*s disease recurrence.

Primary Objective:to assess the safety and tolerability of TAK-018 in postoperative subjects with CD afterlaparoscopic ileocecal resection with primary anastomosis.Secondary Objectives:to evaluate the impact of TAK-018 on intestinal inflammation…

A phase I randomized, double-blind, placebo-controlled, multiple ascending dose study to evaluate the safety, tolerability and pharmacokinetics of NPT189 in healthy subjects

The purpose of this study is to investigate how safe the new compound NPT189 is and how well it is tolerated when it is administered to healthy volunteers. NPT189 has been administered to humans before. It has also been previously tested in the…

A phase 1, open-label, non-randomized, 2-period, fixed sequence study to investigate the absorption, distribution, metabolism and excretion of 14C-PF-06651600 and to assess the absolute bioavailability and fraction absorbed of PF-06651600 in healthy male participants using a 14C-microtracer approach

The purpose of this study is to investigate how quickly and to what extent PF-06651600 is absorbed and eliminated from the body (this is called pharmacokinetics). In this study doses of PF-06651600 labeled with very low doses radioactive (14C) will…

Focal Ablative STereotactic RAdiosurgery for Cancers of the Kidney - A Phase II study

The primary objective of this study is to estimate the efficacy of SABR for primary RCC.

A randomized, double-blind, double-dummy, placebo-controlled, 3-way crossover proof of concept study of intradermally administered desmopressin in healthy volunteers using a nanoporous microneedle array.

1) To evaluate the safety and tolerability of MLT*s npMNAs2) To evaluate the pharmacokinetics of intradermal desmopressin administration via MLT*s npMNAs

If suicide and suicidal expressions color the day: what does that do to you and me? A qualitative study on the experiences and needs of adolescents and social workers in youth mental healthcare and its collaborating partners

The aim of this research is to gain insight and knowledge about the perception of adolescents, social workers and their chain partners in living groups where suicide problems occur.To achieve this goal, a main research question has been formulated…

A Powerful Story- An Evaluation Study of a Life Story Intervention to promote Recovery in People with Personality Disorders in the Third-line Health Care

This evaluation study builds on a preliminary design study, in which 'A Powerful Story' is designed. The primary aim of the current study is to investigate the feasibility of the intervention 'A Powerful Story' in the treatment…

A Phase II basket study of the oral selective pan-FGFR inhibitor Debio 1347 in
subjects with solid tumors harboring a fusion of FGFR1, FGFR2 or FGFR3

Three cohorts will be included consisting of subjects with biliary tract cancer (Cohort 1), urothelial cancer (Cohort 2) and all other solid tumorhistologies not included in Cohorts 1-2 such as NSCLC, head and neck cancer, thyroid cancer, oral…

ASICS trial: Avoiding Sentinel lymph node biopsy In select Clinical node negative breast cancer patients after neoadjuvant Systemic therapy

The primary objective is to evaluate whether SLNB can safely be omitted in breast cancer patients with HER2+ or TN tumors who achieve rCR on MRI after NST. Secondary, quality of life will be assessed in patients with and without SLNB.