2920 results
To determine the incidence and severity of deteriorating vital signs in frail cardiac surgery patients after ICU discharge using continuous remote monitoring. The central hypothesis of this study is that deteriorating vital signs are common and…
The aim of the study is to compare an investigational injection system (Centargo) to the currently available Stellant CT injection system (with Multipatient disposable kit), in terms of efficiency, cost, performance, and user satisfaction (phase 1…
The aim of this study is to assess the safety and clinical performance (both for patient and doctors) of the PICO 7Y system in delivering NPWT simultaneously to two closed incisions following bilateral oncoplastic breast surgery.
1. To assess the safety, tolerability, and efficacy of ABBV-3373 administered every other week (eow) intravenously (IV) in subjects with moderately to severely active RA on background MTX.2. To compare clinical efficacy of ABBV-3373 with adalimumab…
Single-stage bone-anchored hearing implant surgery in the pediatric population using the BHX implant
To compare implant loss between single-stage BAHI surgery (test group) and two-stage BAHI surgery (control group) in children. Furthermore, to compare soft tissue status, time to loading and duration of surgery between groups.
To evaluate the cost-effectiveness of treatment with a circumferential cast compared to treatment with a splint, in patients with a reduced distal radius fracture. The hypothesis is that reduced distal radius fractures treated with a circumferential…
The goal of this study is to test the effectiveness of using the ArmAssist and Antari Homecare platform at home on upper extremity function in chronic stroke patients.Secundairy objectives are:- To evaluate the user-friendliness of the ArmAssist and…
The main aim of the current study is to investigate the effect of a 12 week dietary intervention focusing on increasing vegetable intake on 24h blood pressure. Besides, we want to investigate the effects on:- Plasma concentrations: plasma nitrate…
Primary objective• To determine the optimal dose of IMU-838 to induce symptomatic remission (based on stool frequency [SF] and abdominal pain [AP], as assessed in the Crohn*s Disease Activity Index [CDAI] patient reported outcome [PRO]-2) in…
Investigation of the blood B cell compartment in family members of CVID patients (with and without a CVID family history) to identify or exclude B-cell defects and to improve our insight into a potential familial background of CVID.
The primary objective is to provide dose-ranging data for 4 dose regimens of BI 655130 (with each regimen consisting of a loading and a separate maintenance subcutaneous dose) compared to placebo. The target dose(s) will be estimated from the model…
This study will evaluate the efficacy and safety of ocrelizumab (Ocrevus®) compared with placebo in patients with PPMS, including patients later in their disease course.
Primary objective:* To determine the relative bioavailability of ASN120290 from a film*coated tablet given under fasted conditions versus a capsule formulation given under fasted conditions.Secondary objectives:* To determine the relative…
Primary objectives* To correlate social, physical, and biometric activity of FSHD patients with the FSHD Clinical Score (Lamperti) and the Timed Up-and-Go Test.* To evaluate the feasibility and subjective burden of remote monitoring in FSHD patients…
The primary objective of the CATCA-study is to develop a cfDNA based screening/surveillance tool for colorectal adenoma and cancer, both in the setting of the national CRC screening program and in the surveillance of LS carriers. Additionally, we…
Primary objective:- To evaluate pain and discomfort during and after injection of CM with varying temperatures (20° C and 37° C).- To evaluate the liver attenuation (HU) and image quality (IQ) using iodine injected with various temperatures (20°C…
Primary objective: To evaluate the efficacy of JNJ-68284528 (Phase 2)Secondary objectives:# To characterize the safety of JNJ-68284528 (Phase 2)# To characterize the pharmacokinetics and pharmacodynamics of JNJ-68284528# To assess the immunogenicity…
The objective of this study is to test the CBM eHealth app, with regard to the influence of the app on implicit fatigue self-concept and on explicitly experienced fatigue and vitality, both immediately after finishing the two-weekly training.…
The primary objective of this study is to investigate the role of vascular cells, with focus on pulmonary arterial endothelial cells (PAEC), in the development and pathogenesis of extensive thromboembolisms as observed in CTEPH.
To assess the clinical feasibility, reliability and validity of the combined barocontrol PPG-NIRS-ECG monitor.