2920 results
We aim to investigate the predictive value of the wheezing phenotypes EVW and MTW at preschool age (based on prospectively reported symptoms of wheezing, dyspnoea and cough or based on clinical assessments) and the predictive value of viral upper…
Primary objective:(1) To evaluate the efficacy of the B-FIT aerobic training program on physical fitness of individuals with PPS in the US and the Netherlands.Secondary objective:(2) To evaluate the patient and healthcare professional satisfaction…
The objective of this project is to gain a better understanding of the relation between blood glucose levels and patterns, and contextual data in individuals with T2D. An enhanced understanding of this relation can provide insights on how…
This study has been transitioned to CTIS with ID 2024-514055-15-00 check the CTIS register for the current data. Primary: • Investigate the effectiveness and tolerability of methotrexate as first-line therapy in patients with pulmonary sarcoidosis…
Prediction of adalimumab steady-state levels, based on 2 adalimumab levels in the induction phase of therapy with InsightRx.
Primary Objective: To evaluate the achievement of partial remission by apremilast combined with doxycyclineat week sixteen (t=16). Secondary Objectives: • Complete remission at week sixteen; • Disease control at week six (t=6); • Drug survival;•…
Determination of the individual genotypes for drug metabolizing enzymes and transporters among volunteers, in order to design dedicated clinical trials in a subpopulation, for (potential new) drugs that are substrates, inducers or inhibitors of…
All efficacy study objectives will be assessed in the pediatric AS study population of subjects who are 4 to 12 years old. All safety study objectives will be assessed in the pediatric AS study population of subjects who are 2 to 12 years old.…
To compare the effect of a HCPAP with LCPAP on oxygenation in the first 5 minutes during stabilization in preterm infants at birth.
To study whether epigenetic profiles of study participants who suffered an out-of-hospital cardiac arrest (OHCA) that were collected immediately after OHCA (in ARREST biobank) are similar their epigenetic profiles collected at least 9 months after…
The first objective is to investigate whether biofeedback on HRV and voice volume will lead to a larger decrease of IPV compared to treatment as usual (CBT only). Second, to test the premise that IPV perpetrators have trouble self-observing bodily…
We aim to grow organoids from a large series of patients with gastric or esophageal cancer. The effect of the standard regimens of chemotherapy of radiotherapy is assessed on the organoids in vitro and correlated to the pathological response of the…
We aim to establish proof-of-concept for use of pembrolizumab as novel neo-adjuvant therapy in dMMR and POLE-EDM UC. When ICB proves to be feasible as defined in the primary endpoint (see 2.1), we will follow-up with larger studies to determine…
Main objective:To explore the impact of setmelanotide on obesity in patients with various specific rare genetic mutations.Secondary objective:To assess the effects of setmelanotide on:* Safety and tolerability-Hunger* Waist circumferenceOptional sub…
Primary objective: To determine the prevalence of AKI in critically ill children based on clearance of iohexol.Secondary objectives:1. To determine the prevalence of AKI in critically ill children using serum creatinine, creatinine clearance,…
Primary: To characterize safety and tolerability of each treatment arm tested and identify recommended doses and regimens for future dosesSecondary:* To characterize the pharmacokinetic profile of each investigational drug within each treatment arm…
The primary objective is to evaluate the effect of preoperative weight loss (by means of a 14-day low-calorie diet) on the operative time of the RYGB procedure. The first secondary objective is to evaluate the effect of preoperative weight loss on…
The investigators aim to assess the effectiveness of a specific multispecies probiotic preparation (Winvloce 612) in reducing the incidence of AAD in children.
The primary objective of the study is to evaluate the clinical efficacy of antisense inhibitor of prekallikrein (ISIS 721744) in patients with hereditary angioedema (HAE) type 1 (HAE 1), HAE type 2 (HAE 2), or HAE with normal C1-inhibitor (C1-INH).…
The current trial aims to demonstrate that sugammadex is generally safe and effective for reversing both moderate and deep block after rocuronium or vecuronium induced NMB in term neonates and young children.