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Feasibility, functionality and comfort of a novel concept Ankle-Foot-Orthosis for equinus foot

The objective of this study is to test the feasibility, functionality and comfort of the AFO as an aid to regain the active RoM of the ankle joint in UMND patients with equinus foot. Results of the study will be used to further optimize the AFO…

A Clinical Randomized Controlled RSA Trial Comparing the Cemented ATTUNE (S+Tibia tray) Fixed Bearing Cruciate Retaining Knee System with the Cemented PFC Sigma Fixed Bearing Cruciate Retaining Knee System

The objective of this study is to accurately assess and compare migration, clinical and radiological outcome and patient reported outcomes of two TKR prostheses: the Cemented ATTUNE (S+Tibia component) Fixed Bearing Cruciate Retaining Knee System…

A Randomized, Double-blind, Adaptive, Phase II/III Study of GSK3359609 or Placebo in Combination with Pembrolizumab for First-Line Treatment of PD-L1 Positive Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (study 209229)

Primary: • Compare the efficacy of GSK3359609 in combination with pembrolizumab to pembrolizumab plus placebo in the PD-L1 expression positive (CPS >=1) population and in the PD-L1 expression high (CPS>=20) populationSecondary: •…

A randomized, open-label, phase I/II open platform study evaluating safety and efficacy of novel ruxolitinib combinations in myelofibrosis patients

To characterize the safety, tolerability, and recommended phase 2 dose (RP2D) of each combination partner used with ruxolitinib (Part 1)To evaluate the preliminary efficacy of each novel ruxolitinib combination treatment arm (Parts 2 & 3)

Interventional, open-label, exploratory study, investigating the safety, tolerability, pharmacokinetics, and efficacy of Lu AF28996 in patients with Parkinson*s disease

Main objectives:To evaluate the safety and tolerability of Lu AF28996 after up-titration of oral dose(s) in patients with Parkinson's Disease (PD)To investigate the pharmacokinetic properties of Lu AF28996 after up-titration of oral dose(s) in…

Pseudoxanthoma elasticum: a cohort study and design of a registry.

To collect data in order to create a registry that can be used for research in PXE, partly with an international questionnaire, and to measure PPi, ENPP1 activity, anti-retinal antibodies and cytokines, and retinal calcification in all patients…

Sleep positional therapy for the treatment of nocturnal gastroesophageal reflux

The main objective of the study is to assess the effect of sleep positional therapy, using the LEFT device, on nocturnal gastroesophageal reflux.

Value of 7 Tesla in gliomas

The primary objective is to identify and describe radiological tumor characteristics of glioma on 7 T MRI (possible relevant sequences: 3DT1, 3DT2, TOF, SWI (Duyn), FLAIR, spectroscopy and CEST) and 1.5/3 T MRI (relevant sequences: T1WI with and…

HELIOS-A: A Phase 3 Global, Randomized, Open-label Study to Evaluate the Efficacy and Safety of ALN-TTRSC02 in Patients with Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)

This study has been transitioned to CTIS with ID 2023-508365-33-00 check the CTIS register for the current data. To determine the efficacy of ALNTTRSC02 in patients with hATTR amyloidosis by evaluating the effect on neurologic impairment. To…

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the
Efficacy and Safety of AG10 in Subjects with Symptomatic Transthyretin
Amyloid Cardiomyopathy (ATTRibute-CM Trial)

Key PrimaryPart A• To determine the efficacy of acoramidis (AG10) in the treatment of subjects with symptomatic transthyretin amyloid cardiomyopathy (ATTR-CM) by evaluating the difference between the acoramidis and placebo groups in the change from…

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo- and Active-Controlled, Treat-Through Study to Evaluate the Efficacy and Safety of Mirikizumab in Patients with Moderately to Severely Active Crohn's Disease

MAIN Trial:Primary:To evaluate whether the efficacy of mirikizumab is superior to placebo in participants with Crohn's disease as assessed by- clinical response by patient reported outcome (PRO) at Week 12 andendoscopic response at Week 52-…

A Phase 2, Multicohort Open-Label Study of JNJ-68284528, a Chimeric Antigen Receptor T cell (CAR-T) Therapy Directed Against BCMA in Subjects with Multiple Myeloma

This study has been transitioned to CTIS with ID 2023-506587-13-00 check the CTIS register for the current data. The safety and efficacy of JNJ-68284528 in heavily pretreated patients with multiple myeloma is being evaluated in the Phase 1b/2 Study…

Deep brain stimulation for refractory tinnitus

The goal is to assess the effect of MGB-DBS on tinnitus severity. Secondary objectives are:- To assess side effects of MGB-DBS on hearing and neuropsychological functioning.- To explore neurophysiological hallmarks.

Pragmatic randomised controlled study to assess the effectiveness of two patient management
strategies in mild-to-moderate Ulcerative Colitis

The purpose of this pragmatic randomised controlled study is to compare two patient management strategies in mild-to-moderate UC disease. The goal of the study is to propose a new patient management strategy to both physicians and patients, as an…

Determining the causative agent and optimal duration of antibiotic therapy in persons with diabetes and foot osteomyelitis: BonE BiOPsy (BeBoP) trial

Primary Objective: To prospectively compare outcomes of subjects with diabetic foot osteomyelitis treated with antibiotics targeted at culture results from bone biopsy (intervention group) versus therapy targeted at ulcer bed biopsy culture results…

A Phase 2, Multicenter, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AL001 in Heterozygous Carriers of Granulin or C9orf72 Mutations Causative of Frontotemporal Dementia

Primary ObjectivePart1: To evaluate the safety and tolerability of intravenous (IV) administration of AL001 over up to 96 weeks in asymptomatic and symptomatic carriersof a granulin (GRN) mutation causative of frontotemporal dementia (FTD) and in…

Open vs arthroscopic distal clavicle excision: a randomized controlled pilot trial

main: to examine the difference in daily shoulder pain (NRS) between the two surgery groups in the first 7 weeks after surgery. Second: to examine the difference in shoulder function (DASH) and the chance of complications (frozen shoulder/wound…

Cortical networks and visuomotor abilities in primary brain tumor patients (CANVAS)

In this project, we focus on the cortical network (connectome) involved in visuomotor control. The projects aims to:- Map out higher order visual and motor functions in primary brain tumour patients. - Explain variability in performance on the basis…

A randomized, double-blind, multicenter study assessing short (16 weeks) and long-term efficacy (up to 1 year), safety, and tolerability of 2 subcutaneous secukinumab dose regimens in adult patients with moderate to severe hidradenitis suppurativa (SUNRISE)

Main Objective:To demonstrate the efficacy of secukinumab compared to placebo withrespect to HiSCR after 16 weeks of treatment.Secondary objective:To demonstrate the efficacy of secukinumab compared to placebo after 16 weeks of treatment with…

A Multicenter, Double Blind, Randomized, Controlled Study of M7824 with Concurrent Chemoradiation Followed by M7824 versus Concurrent Chemoradiation Plus Placebo Followed by Durvalumab in Participants with Unresectable Stage III Non-small Cell Lung Cancer

To evaluate PFS in participants treated with cCRT plus M7824 followed by M7824 or cCRT plus placebo followed by Durvalumab