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Hemodynamic Monitoring with the CardioMEMS PA sensor and Quality of Life in Patients with Chronic Heart Failure: The MONITOR HF Trial

We hypothesize that the CardioMEMS HF system will be safe and superior to standard care in improving the quality of life and health status in patients with chronic HF in the Netherlands. Additionally, we hypothesize the CardioMEMS HF system is cost-…

Progression of fibrosis in treated autoimmune hepatitis

Identify markers predicting progression of fibrosis in treated autoimmune hepatitis patients

Changes in sleep and arousal patterns of infants during and after the transition from home to day-care: an observational pilot study

Primary Objective: To describe the sleep and arousal patterns of firstborn infants between two and six months of age in day-care compared to home settings during and after the transition from home to day-care. Secondary Objective: To identify…

The impact of neuromuscular relaxation and nociception guided anaesthesia on hemodynamic variables during abdominal laparoscopic surgery: a strategy trial.

to study the effect of depth of neuromuscular block and nociception level guidance on hemodynamic variables during abdominal laparoscopic surgery

COLLISION-XL trial: Unresectable colorectal liver metastases: stereotactic body radiotherapy versus microwave ablation - a phase II prospective randomized controlled trial for CRLM 3-5 cm

The primary objective is to compare efficacy of MWA to the efficacy of SBRT with regards to the primary endpoint (local tumour progression free survival at 1 year [1-year LTPFS]) in patients with unresectable CRLM (3 - 5 cm) that are unsuitable for…

*Evaluating the feasibility of intraluminal oxygen administration at the site of the anastomosis in patients who underwent an esophagectomy; a pilot study*

To explore feasibility of intraluminal oxygen administration at the site of the anastomosis in patients who underwent an esophagectomy.

The long-term consequences of vulvar lichen sclerosus in adult women who were diagnosed in childhood or adolescence

The goal of this study is to assess the repercussions of juvenile vulvar lichen sclerosus as an adult, and to improve care after the diagnosis of JVLS has been made.

A Phase 1/2 trial on the safety, tolerability, pharmacokinetics,
pharmacodynamics and exploratory efficacy of DYN101 in patients >= 16
years of age with centronuclear myopathies caused by mutations in DNM2
or MTM1

Primary Objective• To assess the safety and tolerability of 3 single ascending dose (SAD) levels and 3 MAD levels of DYN101.Secondary Objectives• To assess the PK of SAD and MAD of DYN101.• To explore target engagement in muscle of DYN101.…

A Phase 3, Randomized, Open Label Study to Compare Nivolumab plus Concurrent Chemoradiotherapy (CCRT) followed by Nivolumab plus Ipilimumab or Nivolumab plus CCRT Followed by Nivolumab vs CCRT followed by Durvalumab in Previously Untreated, Locally Advanced Non-small Cell Lung Cancer

The study objectives and endpoints described below will be evaluated for the following treatment regimens:• Arm A: Nivolumab + CCRT followed by nivolumab + ipilimumab maintenance• Arm B: Nivolumab + CCRT followed by nivolumab maintenance• Arm C:…

An Open-Label, Multicenter, Extension Study of AG-348 in Adult Subjects with Pyruvate Kinase Deficiency Previously Enrolled in AG-348 Studies

Objectives: Primary:• To evaluate the long-term safety and tolerability of AG-348Secondary:• To evaluate the long-term efficacy of AG-348• To evaluate the efficacy of AG-348 in increasing hemoglobin (Hb) concentrations in subjects who previously…

Collaborative care program for patients with treatment resistant schizophrenia.

- Identifying phenomena and relationships/patterns through in-depth study of a limited number of cases and get insight in the impact of CCP for TRS on functioning, psychotic symptoms, quality of life, recovery, self-management, shared decision-…

A multicentre single arm phase II trial assessing the efficacy of immunotherapy, chemotherapy and stereotactic radiotherapy to metastases followed by definitive surgery or radiotherapy to the primary tumour, in patients with synchronous oligo-metastatic nonsmall cell lung cancer

This study has been transitioned to CTIS with ID 2024-511134-12-00 check the CTIS register for the current data. The objective of this trial is to evaluate progression-free survival in synchronous oligometastatic NSCLC patients treated with…

A Phase III, multicenter, randomized, double-blind study to assess efficacy and safety of two doses of crizanlizumab versus placebo, with or without hydroxyureal/hydroxycarbamide therapy, in adolescent and adult sickle cell disease patients with vaso-occlusive crises (STAND)

This study has been transitioned to CTIS with ID 2023-508689-14-00 check the CTIS register for the current data. To compare the efficacy of 7.5 mg/kg of crizanlizumab versus placebo on the annualized rate of VOC leading to healthcare visit, in…

The roles of Attachment Style and Autonomy on Inter-Personal Distance and respons time in Virtual Reality in patients with persistent psychopathology.

Examining inter-personal distance in Virtual Reality in patients with persisting psychopathology and a control group in order to assess the association with attachment styles. Differences in gender will also be examined. Primary research question…

A Study of Disease Progression in Genetically Defined Subjects With Geographic Atrophy Secondary to Age-Related Macular Degeneration

To evaluate the natural progression of anatomical and functional visual parameters in genetically defined subjects with Geographic Atrophy (GA) due to Age-related Macular Degeneration (AMD).

Next Move in Movement Disorders

The primary objective is the development of a computer-aided diagnosis tool (CAD-tool) that enables specialists to improve the diagnosis, treatment, and evaluation of hyperkinetic movement disorders. The secondary objectives is are: 1) To analyze…

The MyHeart Counts cardiovascular Health Study Netherlands

The primary aim is to assess the effectiveness of four coaching interventions in increasing daily activity of MyHeart Counts app users. Secondary aims are 1) to study the feasibility (technical, legal and ethical, data quality, costs) of the MyHeart…

Triathlon Tritanium Tibia Registery; national multicentre surveillance register

To verify the uncemented Triathlon Tritanium Knee System safety during follow-up and survivorship as described by Kaplan-Meier survival curves.To document the patient clinical outcome of the patients who have received an uncemented knee arthroplasty…

A phase 2 study of trifluridine/tipiracil in patients with ER-positive, HER2-negative advanced breast cancer that previously received chemotherapy

This study has been transitioned to CTIS with ID 2024-519204-27-00 check the CTIS register for the current data. To evaluate the efficacy of trifluridine/tipiracil by determination of the percentage of patients being progression free at 8 weeks on…

Longstanding Exercise Therapy in Patients with Rheumatoid Arthritis

This study aims to underpin the delivery of longstanding exercise therapy in the subgroup of patients with RA and complex disability.There are 2 research questions to be addressed 1. Is longstanding, optimized active exercise therapy more effective…