2920 results
To identify predictors of success of AF ablation including clinical factors, AF recurrence patterns, anatomical and electrophysiological characteristics, circulating biomarkers and individual genetic background.
Primary:• To compare the efficacy of viltolarsen administered intravenously (IV) at weekly doses of 80 mg/kg over a 48-week treatment period vs. placebo controls in ambulant boys ages 4 to <8 years with DMD using the Time to Stand Test (…
This study has been transitioned to CTIS with ID 2024-514615-10-01 check the CTIS register for the current data. This study investigates the effectivity and the safety of deferoxamine use in patients with aneurysma subarachnoidhemorrhage.
The study is divided into two sections:Part A is a healthy volunteer controlled observational study to determine the course of the disease over time to:- Evaluate disease-related biomarkers in psoriasis when compared with healthy volunteers;-…
The main objective of this study is to determine the effects of 8 weeks aerobic exercise pre-conditioning (to improve muscle fiber perfusion capacity) on the increase in skeletal muscle mass and function during 12 weeks of resistance exercise…
Primary Objectives• Employ a systems biology approach to identify a set of candidate biomarkers (BM) in circulation and/or pathways & mechanisms that correlate with particular non-AIDS defining comorbidities (ie NASH, CVD) in HIV+…
The aim of this study is to determine whether direct tubal flushing with oil-based contrast at HSG incorporated in the fertility work-up results in 10% more ongoing pregnancies and a shorter time to pregnancy, which will therefore be effective and…
The primary objective of this study is to investigate the effects of breads made from well-characterised Bread wheat, Emmer wheat, or Spelt wheat of fully known composition each yeast (study A) or sourdough (study B) fermented on intestinal symptoms…
Primary Objectives- To objectively quantify the spatial and temporal kinetics of perfusion and wound healing using clinical imaging and evaluations between diabetic wounds before and after endovascular revascularization and between diabetic patients…
To demonstrate the superiority of S 95005 + bevacizumab over capecitabine + bevacizumab in terms of Progression-free survival (PFS) based on Investigator assessment in first-line treatment of patients with unresectable metastatic colorectal cancer…
This study has been transitioned to CTIS with ID 2024-513537-21-00 check the CTIS register for the current data. To investigate the association between quantitative changes in whole body F-18-PEG Folate PET/CT (Folate PET) after 4 weeks and clinical…
To study the effect of local antifungal treatment of the toenails
Primary objective: Inpatient Group: The primary objective of the research with the inpatient group is to assess whether there is a treatment effect in cognition (at T2) compared to baseline (T1) using conventional rehabilitation, as compared to…
Primary Objective:1) Assess different LV loading mechanisms in Barlow's Disease (BD) versus Fibroelastic deficiency (FED), including transvalvular mitral regurgitant and prolapse volume, both with echocardiography and cardiac magnetic resonance…
The objective is to characterize intrarenal T cells isolated from transplant biopsies both phenotypically and functionally.
Objectives: 1) The development of an optimal point-of-care (POC) breath test for an early asthma diagnosis in preschool wheezing children; 2) To unravel important pathogenetic mechanisms in the early development of viral wheeze and asthma by…
The primary objective is to compare the effectiveness of ambroxol versus placebo on the MDS-UPDRS part III motor sub-score in the *practically defined OFF-medication state* in patients with moderate PD, carrying a GBA mutation. The hypothesis is…
The main goals of this study are to study the effects of VHPSD ablation on the duration of a pulmonary vein isolation procedure, and on transient (edema) and persistent (fibrosis) effects of VHPSD ablation in the left atrial wall.
1. To determine biomarkers of response and non-response to treatment for active SLE in a prospective study where patients will be allocated to therapy according to current clinical practice and the EULAR guidelines (response biomarker study; 3TR SLE…
This study is aimed at investigating the effect of imagery rescripting on selfreported low self-esteem in personality disorders and the effect on diverse complaints (anxiety, depression), wellbeing and core cognitions. This might be a step into…