2920 results
The objective of this study is:1. To evaluate the efficacy, safety and the tolerance of Canakinumab in 'IVIG-resistent' patients (cohort 1) and 'IVIG-naive' patients (cohort 2) with Kawasaki disease.2. To evaluate the incidence…
This study has been transitioned to CTIS with ID 2024-510630-40-00 check the CTIS register for the current data. The objective of this prospective, randomized study is to investigate the efficacy and safety of HSCT compared to the comparator group (…
To evaluate the effect of tezepelumab as compared with placebo on COPD exacerbations in subjects with moderate to very severe COPD
To prospectively validate the safety and efficiency of management according to the YEARS algorithm to safely rule out clinically suspected PE in patients with active malignancy to be compared with `standard' management by CTPA alone in a…
This study has been transitioned to CTIS with ID 2024-512571-12-00 check the CTIS register for the current data. The objective of the proposed study is to assess the effectiveness and cost-effectiveness of the use of oil versus water-based contrast…
This study has been transitioned to CTIS with ID 2024-511010-21-00 check the CTIS register for the current data. To prevent the development of chronic postoperative pain after inguinal hernia surgery and knee replacement surgery and to to further…
Study endpoints: This study will capture the following endpoints: 1. To determine if use of IIa antagonist(Dabigatran) is associated with increased platelet activation as compared to Xa(Apixaban, edoxaban, rivaroxaban) 2. To determine if use of IIa…
Primary Objective: To compare the difference in clinically relevant AL after 90 days between perfusion assessment with ICG and standard surgery in colorectal anastomoses.Secondary Objective(s): 1. Change in surgical plan will be assessed within each…
Primary aim1) To investigate what proportion of levothyroxine users aged 60 years and older can withdraw from levothyroxine treatment successfully, defined as having normal fT4 levels and TSH levels <10 mU/L at 52 weeks after start of the…
The main objective is to assess whether Bediol (containing THC and CBD) co-treatment will reduce opioid side effects in chronic pain patients. A secondary objective will be that Bediol is superior to oxycodone in the relief of chronic fibromyalgia…
This study aims to underpin the delivery of longstanding exercise therapy in the subgroup of patients with axSpA and complex disability.There are 2 research questions to be addressed 1. Is longstanding, optimized active exercise therapy more…
This study has been transitioned to CTIS with ID 2024-511205-33-00 check the CTIS register for the current data. Dose Expansion:Primary Objective-*To investigate the antitumor activity of HE3-DXdSecondary Objectives-*To assess the safety and…
To survey the clinical and biochemical characteristics of individuals diagnosed with OCTN2, CPT2, CACT or BKT deficiency or suspected with OCTN2 deficiency after NBS in the Netherlands to aid the decision on whether or not to include these disorders…
To evaluate the efficacy of tofacitinib treatment in patients with RCDII with persistent or recurrent villous atrophy (Marsh III ABC) and aberrant IEL T-cells (> 20% as assessed by flow cytometry).
Primary Objective:• To assess and compare efficacy of sacituzumab govitecan to TPC as measured by progression free survival (PFS) as determined by blinded independent central review (BICR) using Response Evaluation Criteria in Solid Tumors Version 1…
The primary objective is to demonstrate proof of concept by exploring to what extent combinations of clinicipathological factors, multispectral magnetic resonance imaging (MRI), and liquid biopsies prior to, during and after completion of NAC, are…
To obtain fresh mononuclear cells from healthy volunteer donors to be used for validation of procedures for the generation of GMP-grade T cell or tolerogenic dendritic cell products for clinical application.
Primary objectives1A. To evaluate the effect of maximal LDL-C reduction by Evolocumab on top of high intensity lipid-lowering therapy , initiated immediately after invasive ACS treatment on functional impairment of non-infarct related artery (non-…
The primary objective is to examine the influence of assistive soft-robotic glove use on actual use of the arm and hand in daily life. Secondary objectives are to examine retention of the effect on arm use in daily life after cessation of assistive…
The objective of this clinical study is to assess the safety and effectiveness of the Bolt IVL System for the lithotripsy-enhanced percutaneous coronary intervention of de novo, calcified, stenotic coronary lesions prior to stenting. The data is…