2920 results
This study has been transitioned to CTIS with ID 2024-510768-21-00 check the CTIS register for the current data. This study aims to investigate if fluorescence guided surgery performed with SGM-101 can improve R0 resection rates and allows to find…
The primary objective of the clinical performance study is to demonstrate the clinical performance of VENTANA PD-L1 (SP263) CDx Assay in terms of its ability to identify NSCLC patients who may benefit from treatment with volrustomig plus…
The aim is to determine whether individuals with anxiety-related disorders experience faster functional recovery with BI-CBT compared to weekly CBT. If so, a broader range of treatments, decision support, and a detailed implementation plan will be…
The goal of this study is to elucidate whether oral probiotic treatment change the VMB profile of IVF patients score from Low to Medium/High (based on the ReceptIVFity test), compared to a placebo treatment
To demonstrate superiority of whole gland SBRT with a simultaneous integrated focal boost 35/50 Gy in 5 fractions (Hypo-FLAME) regarding 5-year bDFS compared to the current standard moderately hypofractionated schedule of 62 Gy in 20 fractions of 3.…
Proof of Principle: to assess feasibility to measure; (1) a reproducible 1st thermal IDC, (2) at least 1 recirculation IDC using the FBG photonic sensor both peripheral and nasal. - to compare the acquired Stroke Volume (SV) and Cardiac Output (CO)…
To longitudinally evaluate the substantial differences in anatomical changes in the spine during adolescent growth in girls, at increased risk for scoliosis development, and in adolescent 22q11.2DS patients, that do and do not develop AIS.
To investigate the effects of a 5-day diet with 30% caloric and 70% protein restriction on cardiotoxicity induced by anthracycline treatment in women with triple negative or hormone receptor-positive breast cancer. The biomarker high-sensitivity…
Our first primary research objective is to investigate if and how students are changing their diet toward a more plant-based diet. Our second primary objective is to assess changes in stress by using subjective methods (questionnaires) and a…
Primary objective: To define the optimal cut-off concentrations for the POC hs-cTnI assay to rule out or rule in MI.Secondary objective: To determine and validate an assay-specific 0/1-h algorithm for ruling out and ruling in MI.
To evaluate local complement activation/depositions after intradermal LPS challenge
The primary objective is to evaluate the antral lesion size using ultrahighdensity (UHDx) mapping pre- and post-cryoablation with the 31 mm balloon size CB. Secondary objectives are the proportion of pulmonary veins (PVs) where a 31 mm CB could be…
With the extended LAST STRONG Study, we aim to (1) collect 3-year and 5-year natural history data, (2) implement the natural history data collection into clinical care and international guidelines (reach trial readiness), and (3) do in-depth…
To assess the kinetics of EVs in standard HD, derived from both in- (BI) and outside (TI) the ECC.
The aim of the study is to map the changes that occur in breast tissue composition during pregnancy, lactation and post-lactational involution. The secondary aims are to:• validate the performance of diffuse optical spectroscopic imaging (DOSI)…
To determine the effect of tailored exergaming for inactive patients with HF to reduce their sedentary time, improve their daily physical activity, exercise capacity, decrease frailty and improve health-related quality of life.
Our goal is to perform a multicenter randomized study to compare a less invasive diagnostic workup ARM A (with MRI and surgical inspection reserved for borderline operable cases on MRI) to the standard diagnostic workup (ARM B, without MRI, with…
Primary: To assess the efficacy of GNX compared with PBO, as adjunctive therapy for the treatment of primary seizure types in children with genetically-confirmed PCDH19-related epilepsy during the 17-week double-blind (DB) phase. Secondary: • To…
This study aims to assess if actively training adductor co-contraction in patients with SAPS is clinically effective. A specific therapy protocol is already in practice in the physical therapy department of the Leiden University Medical Center (LUMC…
Primary Objectives: Dose Escalation (SAR441000 Monotherapy): -To determine the maximum tolerated dose (MTD) or maximum administered dose (MAD) and the overall safety and tolerability profile of SAR441000 when administered intratumorally as…