2920 results
The main goal of our study is to determine the function of DUX4 in the human thymus by obtaining residual tissue from inevitable (incomplete) thymectomies during open heart surgery in infants. Our primary objective is to detect germline and skeletal…
To explore the relation between (changes in) cerebrovascular function and the change in cognitive function in older adults with and without MCI across follow-up.
This study has been transitioned to CTIS with ID 2024-518046-25-00 check the CTIS register for the current data. Evaluation of the feasibility of intraoperative visualization of penile and tongue tumours using the fluorescent tracer EMI-137.
To investigate the relationship between subjective and objective ADHD and subjective mood symptoms and the menstrual phase in women with and without ADHD.
Primary objective:- To compare efficacy of induction vemurafenib + cobimetinib followed by ipilimumab + nivolumab (Arm A) versus upfront ipilimumab + nivolumab treatment (Arm B).Secondary Objectives- To describe duration of response and overall…
The purpose of this study is to investigate how quickly and to what extent derazantinib is absorbed (taken up), distributed, metabolized (broken down) and eliminated from the body. The pharmacokinetics of derazantinib when it is administered…
The purpose of this study is to investigate the effects of the new compound efgartigimod on IgG antibodies. It will also be investigated how quickly and to what extent efgartigimod given together with rHuPH20, is absorbed and eliminated from the…
To demonstrate that QIV-HD induces an immune response that is superior to the responses induced by QIV-SD for all 4 virus strains 28 days post-vaccination in subjects 60 to 64 years of age and in subjects 65 years of age and older.
To develop a robust MR imaging protocol applicable in the diagnostic workup and follow up of suspected MD patients.
By evaluating care trajectories of children, adolescents and their families who receive specialized and very intensive forms of psychosocial care, we aim to improve future care. The research should lead to a) knowledge about points for improvement,…
Part 1:To determine the effect of depth of anaesthesia, as quantified by pEEG, on the quality of Tc-MEP measurements during spinal surgery.Hypothesis: lower depth of anaesthesia, defined by higher values of pEEG will:a. Decrease the threshold…
Aim:To evaluate the effects of a structured nursing supportive intervention on family caregivers in palliative home care. Question:What are the effects of a new nurse-led supportive intervention on family caregivers* preparedness and burden?
Primary objective:To evaluate the efficacy of soraprazan in reducing the amount of lipofuscin inRPE cells of subjects with Stargardt disease by assessing the change inquantitative auto-fluorescence (qAF8) from baseline to after treatment…
Primary objective:to assess feasibility of ADD. Pre-defined criteria for feasibility is: 75 percent of included patients complete the intervention.Secondary objectives:1. To describe the components and practical aspects of ADD. These will be…
To evaluate tailoring components in a web application for THA patients and to refine guidelines for tailored web applications for patients.Secondary objectives:- To assess how and how often THA patients use a prototype of the tailored web…
We expect to find links between the preference for simple vs. complex choice strategies and the activity of LC, evident in pupil size and fMRI signal. The study aims to provide novel evidence that 1) pupil dilation to decision cues is linked to…
At the moment it is unknown which radiomics features are robust against variations in image characteristics. The objective of this study is to check the robustness of radiomics features, and to investigate wheter specific pre- and postprocessing…
HV cohort 1Primary Objectives* To characterize the local tolerability of topical bimiralisib after 21 days* To characterize the systemic PK of topical bimiralisib after 21 daysSecondary Objective* To characterize the safety of topical bimiralisib…
The primary objective of this study is to determine the prevalence of contact allergies in patients with diabetic foot ulcers.
The main objective of this study is to develop a prototype mobile apllication to help patients with ADS (normal and above avarege IQ) to detect stress in daily life. The application will not only detect stress, but will help the patient to react o…