2919 results
The primary aim of this study is to assess the effect of a personalized training intervention on CRF during primary rehabilitation. Secondary aims of this study are to determine the effect of this intervention on gait capacity, pulmonary function,…
Transcutaneous auricular vagal nerve stimulation (taVNS) has been recently shown to have analgesic potential in patients with chronic functional abdominal (visceral) pain. Functional abdominal pain, as commonly seen in conditions such as irritable…
To test the feasibility of supplying a tailored, digital health app, designed to increase insight in how to reduce one*s dementia risk, in the general practice. Secondly, we aim to explore the usability of experience-sampling method (ESM) technology…
Assessment of whether fetal RHD genotyping can be performed earlier in pregnancy, i.e. around GW11 instead of the moment around GW27.
The aim of the study is to investigate the accuracy of initial positioning, stability during treatment (intrafraction motion), and the number of interventions (repositioning) for radiotherapy treatments of head and neck cancer patients, positioned…
This study aims to examine the effect of furosemide on renal PBUT excretion and PBUT plasma levels in patients with CKD.
the primary aim is to determine the effect of thawed deep-frozen platelets re-suspended in thawed deep-frozen plasma versus room temperature stored platelets in platelet additive solution for transfusion on the percentage of patients with surgical…
We hypothesize that during an episode of immune-mediated organ specific toxicity, as a result of inflammation and damage to the specific organ, organ-derived DNA will be detectable in blood of patients. The aim of this project is to investigate…
To provide high-quality remote care to patients with type 2 diabetes, using an eHealth platform with support from a medical service center. The present study is optimisation and implementation research. Notably, the aim is not implementation but…
SARS-CoV-2 is related to a number of seasonal coronaviruses that have been endemic in humans for decades and usually cause *common cold* symptoms (HCoVs). Several studies have shown that SARS-CoV-2-specific T-cells can be detected in individuals…
The main objective is to quantify neuroinflammation using [11C]SMW139 PET-scans in subjects along the AD continuum and age/sex-matched cognitively unimpaired subjects.
The aim of the study is to investigate whether SI-NET's can be visualized with Methylene Blue (MB) and near-infrared (NIR) fluorescence imaging.
This study has been transitioned to CTIS with ID 2024-516738-36-00 check the CTIS register for the current data. The primary purpose of this study is to determine the maximum tolerable dose (MTD) of IP monotherapy with paclitaxel for patients with…
The study has two objectives:1. To relate pulmonary fibroblast activity in non-resolving ARDS patients, measured by FAPI-PET/CT, to the 28 days mortality, ventilator-free days of 28 days (VFD-28) and ICU length of stay. 2. To study the relationship…
The primary objective of this study is to evaluate the coronary plaque burden and plaque characteristics in young T1DM patients as compared with non-diabetic healthy controls, using coronary computed tomography angiography (CCTA). The secondary…
Primary:Determine baseline and changes over time in cardiac structure and function in BAG3 associated DCM.Secondary:Assess the progression of prognostic disease biochemical biomarkers in BAG3 associated DCM.
This study has been transitioned to CTIS with ID 2024-515885-15-00 check the CTIS register for the current data. Main objectives:• To evaluate whole body distribution of 89Zr-Df-crefmirlimab in cancer patients prior to and during treatment with an…
1. To examine whether there is an increase in (nigro)striatal dopaminergic functioning in individuals of West-African descent relative to those of Dutch descent (assessed in older participants with DAT SPECT and with NM-MRI in the entire sample). (…
This study has been transitioned to CTIS with ID 2024-514266-39-00 check the CTIS register for the current data. Phase 1 Primary Objective(s):-to evaluate the overall safety and tolerability of NVL-655-to determine the RP2D and, if applicable, the…
In this project we aim to develop a safe and effective technique for ADC/FET-guided resection of IDH-wildtype glioblastoma and grade IV IDH-mutant astrocytoma. The safety concerns neurological deficits and time to start of adjuvant therapy, while…