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Randomized, double-blind, placebo-controlled, study of spesolimab in patients with moderate or severe hidradenitis suppurativa.

The primary objective is to estimate the effect of spesolimab compared to placebo for the mean percent change from baseline in total abscessand inflammatory nodule count at Week 12. Secondary objectives are the evaluation of efficacy of spesolimab…

CHOlesterol effects of KOri-Tofu

The primary objective is to assess the effect of repetitive consumption of Kori-tofu on blood total and LDL cholesterol levels. The secondary objective is to assess the effect of repetitive consumption of Kori-tofu on other markers of lipid…

Operative treatment of AO Weber B fibular fractures with additional posterior malleolar fragment: reduction and functional outcome after prolonged follow up

To asses if there is a difference in functional outcome between open reduction and fixation of the posterior fragment in trimalleolar AO-Weber B fractures with additional medium-sized posterior fragment (5-25% of the involved articular surface, AO…

The effect of plant and animal protein supplements on muscle damage: An explorative study

To investigate the impact of different types of proteins on muscle damage upon an endurance exercise bout in elderly.

Vegan Diets: the short-term effects on daily muscle protein synthesis rates as compared to omnivorous diets in Older adults assessed by D2O.

To investigate the short-term effect of a vegan diet on daily muscle fractional synthesis rates in comparison to an omnivorous diet in community-dwelling older adults.

A feasibility study to evaluate PDE MAX, a food for special medical purposes (FSMP) for use in the dietary management of Pyridoxine Dependent Epilepsy (PDE) with regards to acceptability, tolerability, adherence and effect on metabolic control.

To evaluate product acceptability, tolerance and adherence during an 8-week intake of PDE MAX in patients with Pyridoxine Dependent Epilepsy.To evaluate the effects on metabolic control by comparing the changes from baseline after an 8-week intake…

The Portal venous Content of Microbial Molecules (PoCoMiMo) Study

The objective of the PoCoMiMo study is to compare the abundance, and hepatic clearance of microbiota-derived molecules in the portal venous circulation between patients suffering from a primary hepatic malignancy versus those with pancreatic cancer…

COVID@Home: cardiovascular disease and risk in non-hospitalized Covid-19 patients

Primary and Secondary: To assess cardiovascular function and the presence and magnitude of myocardial injury using echocardiography and cardiac magnetic resonance (CMR) imaging, among community-dwelling individuals who recovered from Covid-19…

The GLYSIMI study: Elucidating the role of human Small Intestine Microbiota in Interpersonal differences in GLYcemic responses upon consumption of food products. A proof of principle study.

The objective of this proof-of-concept study is to investigate (differences in) small intestine microbiota and postprandial glycemic responses.

A single-center, open-label, fixed-sequence Phase 1 trial to evaluate the effect of multiple
doses of pritelivir on the pharmacokinetics of substrates for CYP2C9, CYP2B6, CYP3A4
and OATP2B1

In this study, we will investigate how quickly and to what extent the investigational medicinal product pritelivir is absorbed, transported, and eliminated from the body (this is called pharmacokinetics). In addition, we will evaluate a possible…

MONITOR CF: Monocytes In TiMaSCAN for monitoring respiratory infections in Cystic Fibrosis

Our main aim is to validate the TiMaSCAN as both a diagnostic and monitoring tool in the treatment of pulmonary exacerbations in CF patients.

A lower-limb powered exoskeleton for stroke patients: a feasibility study

Determine if the ABLE-S exoskeleton can provide subject-specific assistance (in terms of type, level and timing of the assistance) to increase forward propulsion, foot clearance and/or knee stability, in hemiplegic stroke patients.

Quantifying blood flow in the aorta using phase-contrast 4D flow MRI

Obtain phased-contrast 4D flow MRI scans in 20 healthy volunteers to quantify local blood flow in the thoracic and abdominal aorta and extract boundary conditions for future in vitro studies. Furthermore, the 3D geometry of the vessels within…

Noradrenergic modulation of learning noise in value-based decision making

The goal of the proposed research is to investigate the behavioral, computational, and neural mechanisms by which a pharmacological manipulation of noradrenergic activity impacts value-based decision making and reinforcement learning. Based on the…

A three-part, open-label, randomized (Part 1) and fixed-sequence (Part 2 and Part 3) study to compare the pharmacokinetics of different ESB1609 Form A formulations to that of ESB1609 Form B (Part 1) and to investigate the effect of CYP2C9 inhibition and induction on the single dose pharmacokinetics of ESB1609 Form A (Part 2 and Part 3).

Part 1:Primary objective:• To evaluate the PK profile of a single oral dose of ESB1609 jetmilled Form A in plasma and compare this profile with the PK profile of ESB1609 monohydrate Form B with 30% SLS.• To compare the PK profile of different…

Immunological characterization of TLR-7 mediated inflammation and complement activation after prolonged Imiquimod exposure in healthy volunteers

Primary* To immunologically characterize imiquimod-induced inflammation after 7-day exposure of healthy skin;* To evaluate local complement activation/depositions after a prolonged topical imiquimod challenge;* To evaluate systemic activation of…

Long-term follow up of overweight and obese women with PCOS who participated in a randomized controlled three-component lifestyle study

The aim is to evaluate long-term (+/- five years post-intervention) follow-up results of a previously completed study that investigated the effect of a three-component (diet, exercise, cognitive behavioural therapy (CBT)) lifestyle intervention with…

EUS-guided choledochoduodenostomy (versus ERCP) for primary drainage of malignant distal biliary obstruction: a pilot study

To establish the effectiveness and safety of EUS-CD as the primary drainage strategy in patients with malignant distal biliary obstruction.

The impact of ingesting a whole-food animal-based versus plant-based protein rich meal on the muscle protein synthetic response in healthy older men and women

To compare the post-prandial muscle protein synthetic response following ingestion of a whole-food meal containing meat versus the ingestion of a meal containing only plant-based protein sources in vivo in healthy, older men and women.

Feasibility of CT-guided percutaneous needle puncture for kidneys with CASone system

The aim of this study is to demonstrate the feasibility of CBCT-based stereotactic navigation to perform a better and optimal renal access puncture, which may enable higher stone free rates. This may lower intraoperative ERD during PCNL with…