470 results
Valemetostat tosylate may modify epigenetic changes, which plays an important role in the pathogenesis of PTCL. In the ongoing open-label Phase 1 study (DS3201-A-J101, 25 Dec 2019 data cut-off), valemetostat tosylate monotherapy demonstrated…
Aim 1. To study the impact of different sequences of combined influenza and SARS-CoV-2 vaccinations on immunological responses and sideeffects.Aim 2. To understand the immunological mechanisms that mediate the potential interference between…
To evaluate a probiotic formula, including selected strains able to produce neurotransmitters, vitamin D, B6, and zinc to provide new, safe and effective therapeutic option for:- Boosting cognitive performance- Prevent the onset of memory impairment…
- Characterization of the CNS PD profile of IV administered biperiden- Characterization of the pharmacokinetic profile of IV administered biperiden- To confirm the plasma concentration-effect relationship of biperiden using population PK-PD modeling…
Primary* To explore the pharmacokinetics of insulin aspart after pulsed intra-vaginal delivery using the MedRing and after subcutaneous injection in women with DM1.Secondary* To assess the safety and short-term tolerability of insulin aspart after…
To compare skin condition for monitoring with the Bambi Belt versus skin condition with routine monitoring.
Does HPI with diagnostic guidance affect severity of hypotension (defined as MAP<65 mmHg) during both the off-pump phases of on-pump CABG surgery and the mechanically ventilated phase of post-operative ICU admission (or 8 hours maximum)?
The primary goal of this study is to determine discrepancies between INR measurements with Coaguchek XS and Coagulometer in APS patients. The secondary objective is to investigate which antiphospholipid antibodies correlate with the observed INR…
To evaluate the efficacy, safety, tolerability, in subjects with ALS following the oral administration of study drug (active or placebo capsules).
The objective of the study is to assess the safety and performance of the Cardionomic cardiopulmonary nerve stimulation (CPNS) system in patients with acute decompensated heart failure. The intent of the study is descriptive in nature, without a…
Primary objectives: To determine and compare the diagnostic yield of two different methods (FaceReader technology and a deep learning model specifically developed for video data) to analyse facial weakness from video recordings (04:00m) with…
To determine non-inferiority of the corrected distance visual acuity (CDVA) with the prescription obtained through the web-based measurement of refractive error, compared to usual care, in patients who underwent routine cataract surgery.
The aim of this study is to determine the effects of the SALUD-intervention on food literacy (a measure of food-related knowledge and skills)
The current study will evaluate the safety, pharmacokinetcs and the effects of MG, especially on subjective outcomes, pain perception, cognitive perfomances and impulsivity.
To determine the effectiveness of a decision rule compared to the usual care of GP*s for patients presenting with non-traumatic chest pain in primary care.
This study will evaluate the long-term safety and tolerability of IVT faricimab in patients with nAMD who have completed either of the Phase III (GR40306 or GR40844) studies. Additional assessments relating to efficacy, pharmacokinetics,…
Targeted therapies guided by molecular diagnostics have become a standard treatment of lung cancer. Nowadays, tumour tissue is required to assess the molecular characteristics of the tumour. However, the procedures to obtain tissue are invasive and…
The primary objective of this study is to analyse the feasibility and internal validity of Magtrace in the sentinel node procedure in breast cancer in the Breast Care Centre in Zuyderland Medical Centre; with the ultimate goal to make the sentinel…
Does Mindfulness-Based Cognitive Therapy (MBCT) reduce psychological distress and improve sleep quality and quality of life compared to treatment as usual (TAU) in patients with IBD?
To assess the association between secondary brain injury in intracranial haemorrhage and the involved inflammatory response. We want to correlate perihematomal inflammation, serum inflammation markers, increased blood-brain-barrier leakage and…