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Exploratory study into age-related immunological differences related to immunogenicity in influenza vaccination and herpes zoster vaccination

The general objective of this study is to identify immune senescence related pathways leading to different immunogenicity after administration of unadjuvanted influenza or AS01 adjuvanted herpes zoster vaccines.

The effects of exercise training combined with NR supplementation on metabolic health in older individuals

The primary objective of this study is to determine whether combined treatment of exercise and NR imposes greater improvements in skeletal muscle mitochondrial metabolism in older humans compared to exercise treatment alone. The secondary objective…

An explorative, monocentric, feasibility study to evaluate the detectability of the bladder in healthy subjects by ultrasound monitoring with the early TENA Bladder Sensor prototype

Primary objectives: - To collect raw measurement data of the urinary bladder region of volunteers with the early prototype of the Bladder Sensor in multiple postural positions to evaluate the detectability of the bladder in the intended users - To…

Personalized microbial substrates to prevent type 2 diabetes

In this project we intends to study the therapeutic potential of a personalized fibre mixture in individuals at high risk of developing T2DM, and aims to address the following key objectives: 1. To investigate whether a mixture of fermentable…

Evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of topically applied NT-077 (tiotropium bromide) in healthy volunteers.

Primary objective: - To evaluate the systemic absorption and pharmacokinetics of topically applied NT-077 Secondary objectives: - To evaluate the safety and tolerability of topically applied NT-077- To evaluate the pharmacodynamic effect on sweat…

Targeting Negative *Flashforward* Imagery Using EMDR in Children and Adolescents with Social Anxiety Disorder: a Proof-of-Principle RCT

The main objective is to evaluate the effectiveness of three sessions of EMDR FF (targeting negative FF imagery related to youth*s most feared social situations) in treating social anxiety (lowering anxiety and avoidance related to those feared…

A phase I, open label clinical trial in healthy volunteers, to assess and characterize the effect of FIRTECH infrared patch on tissue perfusion, oxygenation and local microcirculation.

Primary* To assess and characterize the local effect of the FIRTECH patch on local microcirculation.Secondary* To evaluate the effect of the FIRTECH patch on tissue oxygenation and perfusion.* To evaluate the local effect of the FIRTECH patch on…

Pre-BladParadigm - the effect of diagnostic transurethral bladder tumor resection (TURBT) on the level of circulating tumor cells (CTCs) in the blood of patients suspected of muscle invasive bladder cancer

To validate the suggestion that transurethral resection of bladder tumors in patients with suspected muscle invasive bladder cancer can lead to circulating tumor cells.

Interventional, randomized, double-blind, placebo-controlled, single-ascending dose study part investigating the safety, tolerability, and pharmacokinetic and -dynamic properties of Lu AF90103 and a double-blind, cross-over study part investigating the safety profile after infusion of Lu AF90103 at two rates to healthy men.

* to evaluate the safety and tolerability of Lu AF90103 following single ascending intravenous (i.v.) doses* to investigate the pharmacokinetics (PK) of Lu AF90103 (prodrug) and Lu AF88361 (drug) in plasma and cerebrospinal fluid (CSF) following…

Polyethylene Wear of the N2Vac and X3 insert in the Triathlon Total Knee Prosthesis: 10 years follow up of a prospective Randomized Single Centre RSA study

The primary objective is to assess the in vivo wear of the two randomized polyethylene insert types N2Vac and X3 10 years after surgery. The secondary objective is to assess the migration and long-term survival of the Triathlon CS Peri-Apatite…

Long term efficacy and safety of SARS-CoV-2 vaccination in patients with chronic kidney disease stage G4-G5, on dialysis or after kidney transplantation. A prospective observational cohort study by the REnal patients COVID-19 VACcination (RECOVAC) consortium

To assess the efficacy of SARS-CoV-2 vaccination by the incidence of COVID-19 in patients with chronic kidney disease stage G4-G5, on dialysis and patients after kidney transplantation who received SARS-CoV-2 vaccination

Postprandial Lipids in IBS and Nutritional Treatment

The primary objective of this study is to determine the effect of short-term Turmipure GOLD® supplementation on LPS translocation in IBS-D and IBS-M patients after a high-fat challenge.The secondary objective of this study is to determine the effect…

A proteogenomic pipeline for capture and sequencing and production of pathogen-specific antibodies

In this research study we will look whether in the blood of patients who were recently infected with the coronavirus (SARS-CoV-2), antibodies can be found that neutralise the virus. We will produce those antibodies. With the produced antibodies we…

The RTX-COVAC study: humoral response to COVID-19 vaccination after rituximab, and relation with dose and vaccination timing. A prospective cohort study.

To investigate, in RA patients, the role of different RTX doses (200, 500 and 1000mg) and timing of RTX on risk of obtaining adequate humeral response against COVID-19 vaccines, by performing a sensitivity analysis on response, using logistic…

A Phase 1, Randomized, Open-Label, Crossover Study to Evaluate Relative Oral Bioavailability of 2 Formulations of PTC857 When Administered as a Single Dose to Healthy Subjects

In this research study we will compare a new PTC857 formulation to the current PTC857 formulation. The aim of the new formulation is to improve ease of manufacturing and to reduce the effect of food on PTC857 uptake. Our aim is to study how quickly…

Solriamfetol*s Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-controlled Study (SHARP): a 5-Week Double-blind, Placebo-controlled, Randomized, Crossover, Multicenter Study of Solriamfetol in Improving Cognitive Function in Participants With Excessive Daytime Sleepiness Associated With Obstructive Sleep Apnea Plus Impaired Cognitive Function.

Primary Objective: To evaluate the effect of solriamfetol on cognitive functioning using an objective measurement. Secondary Objective:To evaluate the effect of solriamfetol on cognitive functioning using a subjective endpoint

The Galvanize Therapeutics Early Stage, Non-Small Cell Lung Cancer, Treat and Resect Study

To evaluate the safety and initial feasibility of PEF treatment of NSCLC tumors prior to surgical resection.

Safety and Performance Study of Large Hole Vascular Closure Device - Frontier V study

To assess safety and performance of the PerQseal® + Closure Device when used with the L PerQseal®Introducer to percutaneously close femoral artery punctures and to induce arterial haemostasis in patients undergoing endovascular procedures requiring…

Effect of citalopram on chest pain in patients with functional chest pain

To assess the effect of citalopram on symptoms of chest pain in patients with functional chest pain.

CELTiC trial: an international multicentre study evaluating the CELTiC panel for the detection of advanced neoplasia in Feacal Immunochemical Test (FIT)-positive individuals

We aim to estimate the sensitivity and specificity of the CELTiC panel in FIT-positive populations.