123 results
The primary aim of this split-mouth randomized clinical trial is to assess accuracy of bracket positioning of a fully digital IDB workflow compared to a DBB workflow, with IDB bracket planning serving as reference for both methods. The secondary…
Subgroup 1 (complex appendicitis without mass and/or abscess formation): LA is associated with reduced superficial site infections, shorter length of stay, less costs, less pain, and better hr-QoL, compared with OA without compromising overall…
This study has been transitioned to CTIS with ID 2024-513412-10-00 check the CTIS register for the current data. Phase 1: • To determine the MTD/RP2D regimen of brigatinib monotherapy when administered in pediatric and AYA patients with ALK+ ALCL or…
Phase 1: Assess reliability of advanced respiratory muscle ultrasound imaging in healthy subjects and congenital myopathies/muscular dystrophies. Phase 2: assess two year follow-up of respiratory function using advanced respiratory muscle ultrasound…
To investigate whether treating children with high refractive errors at age one with glasses prevents the development of amblyopia.
The aim of the study is to measure the effect on pain during needle-related procedures using VR hypnosis glasses versus hypnosis by a health care professional. Secondarily, anxiety, blood pressure, heart rate and patient satisfaction are measured.
This study has been transitioned to CTIS with ID 2023-507146-91-00 check the CTIS register for the current data. Primary Objective:• To evaluate the safety and tolerability of viltolarsen administered intravenously (IV) at weekly doses of 80 mg/kg…
The first aim is to investigate whether SIP indicators measured with VR are better predictors of aggression in real-life than SIP indicators measured with hypothetical vignettes in youth with MID-BIF. The second aim is to explore whether we can…
The primary objective of this study is to further discribe the natural course and clinical characteristic of infantile FSHD.The secondary objectives are: - To identify (epi)genetic and environmental disease modifying factors that contribute to…
This study has been transitioned to CTIS with ID 2024-517846-32-00 check the CTIS register for the current data. To evaluate the effect of prolonged duration of (fos)aprepitant prophylaxis on the prevention of delayed CINV (complete remission in the…
Monitoring & evaluation of immune responses induced by COVID-19 vaccines in the general population in the Netherlands.
This study has been transitioned to CTIS with ID 2024-514073-22-01 check the CTIS register for the current data. To investigate differences in coagulation between (Omniplasma) and FFP in paediatric cardiac patients, who are undergoing cardiac…
The primary objective is to study the agreement between the peak-to-through EAdi-oes signal and the EAdi-tc signal. Secondary objectives include a) to study the sensitivity and specificity of the EAdi-tc signal to detect dyssynchronous breaths using…
To evaluate product acceptability, tolerance and adherence during an 8-week intake of PDE MAX in patients with Pyridoxine Dependent Epilepsy.To evaluate the effects on metabolic control by comparing the changes from baseline after an 8-week intake…
Our main aim is to validate the TiMaSCAN as both a diagnostic and monitoring tool in the treatment of pulmonary exacerbations in CF patients.
To investigate the differences in participation, motor abilities and function in more dynamic tasks between clubfoot patients with and without relapse and healthy controls.
To assess the PK/PD relationship of prednisolone regarding toxicity as clinical outcome in paediatric patients with autoimmune or autoinflammatory diseases.
Development of a diagnostic algorithm that will diagnose measles cases and classify (potential) contagiousness of patients following measles infection.
To compare skin condition for monitoring with the Bambi Belt versus skin condition with routine monitoring.
The objective of the proposed study is to determine whether the neural mechanisms of word learning change with age. In line with this, we aim to investigate whether the activity of brain regions in this L2 word learning process relate to neural…