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The effectiveness of a virtual reality intervention on trauma-related shame in sexually abused adolescents: A single-case experimental study.

The goal of this study is to test the effectiveness of a short-term VR shame intervention (SHINE-VR) for adolescents suffering from PTSD after having experienced sexual abuse. The primary objectives of this study are:1) To assess the effect of SHINE…

A cognitive reappraisal intervention for the reduction of anxiety in eating disorders: an experimental study with exposure in virtual reality

The current study investigates the effectiveness of an intervention that focusses on the adaptive emotion regulation strategy cognitive reappraisal for people with EDs in the reduction of anxiety. This intervention will be compared to a control task…

The efficacy of laser hair removal therapy in patients with mild to moderate HS, a randomized controlled trial.

The primary objective of this study is to assess whether laser hair removal therapy improves the course and severity of mild to moderate HS, as assessed by the difference in IHS4 between groups over time between month 7 to month 12.

A Phase 3, Randomized, International Multicenter Trial of DAY101 Monotherapy Versus Standard of Care Chemotherapy in Patients with Pediatric Low-Grade Glioma Harboring an Activating RAF Alteration Requiring First-Line Systemic Therapy

This study has been transitioned to CTIS with ID 2024-510742-13-00 check the CTIS register for the current data. The primary objective is to compare the objective response rate (ORR) assessed per Response Assessment in Neuro Oncology for low-grade…

Whole Exome & Whole Genome Sequencing Analysis to Explore Familial Keratoconus

To identify genetic variants for the development and progression of keratoconus using Whole Exome Sequencing and Whole Genome Sequencing approaches on keratoconus families with index patients originating from the Rotterdam Eye Hospital and Erasmus…

A Randomized, Multi-Center Phase III Trial comparing two conditioning regimens (CloFluBu and BuCyMel) in children with Acute Myeloid Leukemia undergoing allogeneic stem cell transplantation.

This study has been transitioned to CTIS with ID 2023-505512-37-00 check the CTIS register for the current data. The primary objective of the randomized part of the protocol is to investigate if a conditioning regimen containing one alkylator (Bu)…

An Open-label Multicenter Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Inebilizumab in Pediatric Subjects with Neuromyelitis Optica Spectrum Disorder

This study has been transitioned to CTIS with ID 2023-510007-22-00 check the CTIS register for the current data. NMOSD is associated with a high degree of disability and mortality, and there is a unmet medical need in children with this disease.…

A pilot study to test the PCOS risk algorithm (PriskA)

In this study we aim to assess the validity of the PriskA algorithm to diagnose PCOS in a pilot study with patients presenting with signs and symptoms of PCOS. The study also aims to collect information on the user experience from the clinicians and…

Identification and functional characterization of causal genetic variants in patients with an unexplained bleeding tendency

Identification, segregation analysis, and functional characterization of genetic variants possibly causing rare bleeding disorders. The following questions will be answered:1) Can we identify (new) causal variants that explain the phenotype of…

Adding DNA-test for screening of HLA-DQ2 and DQ8 to improve the early diagnosis of celiac disease at the Dutch Preventive Youth Healthcare Centres

Primary Objective:1. To validate the HLA-DQ typing in blood taken by a fingerprick; to make it feasible in the regular Preventive YHCCs organization.2. To establish the feasibility of HLA-DQ2/8 typing in the active case-finding at the Preventive…

Child Brain Lab Circuit

Objectives: 1) Create shared and disease-specific developmental curves with relevant and meaningful outcomes in children with brain-related disorders. 2) Develop innovative paradigms and parameters from neurophysiological, brain structure and motor…

Effectiveness of early use of the mechanical insufflation- exsufflation compared to air stacking to reduce respiratory tract infections in patients with Duchenne muscular dystrophy.

The aim of this study is to determine whether MI-E leads to a lower number of RTIs as compared to AS combined with MAC in DMD patients with a PECF< 270 l/min over a period of two years.

A Phase 3, Multicenter, Randomized, Platform Study of p19 Inhibition of the IL-23 Pathway to Establish Efficacy in Pediatric Crohn*s Disease;ISA title: A Phase 3, Multicenter, Randomized Clinical Study to Evaluate Mirikizumab in Pediatric Crohn*s Disease

This study has been transitioned to CTIS with ID 2024-511472-32-00 check the CTIS register for the current data. Primary for Platform-Level Exploratory Analysis1. To evaluate whether treatment with IL-23 inhibitors is superior to adult placebo in…

Prospective rAndomized controlled tRial of Crohn*s diseAse exclusion Diet vs corticosteroIds in patientS with activE Crohn*s disease

Main objective: to assess whether CDED is superior to corticosteroids, in terms of endoscopic response, in patients with mildly to moderately active, luminal CD.

The effects of branch pulmonary artery stenting in d-TGA, ToF and TA: a randomized control trial

The primary study objective is to identify the effects of percutaneous interventions for branch PA stenosis on exercise capacity in patients with d-TGA, ToF and TA. The secondary objectives are 1) to assess the effects of percutaneous interventions…

Toxicological screening with drug of abuse and alcohol test in victims older than 16 years of sexual violence in the Center for Sexual Violence in Gelderland South and Central.

By means of this study we want to determine how many victims of sexual violence, who seek help within 72 hours at the CSG Gelderland Zuid-Midden (CSG-GZM), have alcohol and/or drugs in their urine, voluntarily or involuntarily. To make it clear how…

The additive effect of Imaginary Rescripting for treating depressive symptoms in childhood trauma related depression in adolescence: A multiple baseline study among 15 adolescents

The primary goal is to investigate the effectiveness of Imagery Rescripting as an add-on intervention to care as usual (CAU) for treating clinical symptoms of depression of 15 adolescents who have been exposed to childhood trauma. The secondary…

Evolution over time of exercise capacity in Tetralogy of Fallot, a follow up study of *TOFFIE* study participants

Primary Objective: - To determine the evolution over time of VO2peak, cardiac function, pulmonary function and muscle strength in children and adolescents with rToF and how these relate to each other and to quality of life.Secondary Objectives:- To…

Strong Teens and Resilient Minds: School-based depression and suicide prevention in adolescents attending special schools

The aim of the study is to establish depression and suicide prevention reaching students who attend special education.The primary goal is to evaluate the effectiveness on depressive symptoms of a screening and prevention program for adolescents who…

Smartphone virtual reality exposure before paediatric surgery: effects on pre- and post-procedural pain and anxiety

The objectives of this study are to (1) test the efficacy of sVRE versus CAU in 180 children undergoing surgery on the postoperative pain of the child (primary outcome), postoperative analgesics use, anxiety level of the child during induction of…