15 results
To determine the real world response to standard of care CAR T-cell therapy, in order to better understand the intrinsic and extrinsic factors related to treatment success or failure.
To evaluate the feasibility, safety and potential efficacy of acupuncture in children with FC. The results of this study will be used to design a future randomized controlled trial (RCT).
The primary objective is to identify clinical and biological measures that discriminate paediatric ME/CFS and post-COVID patients from healthy controls based on either clinical (based on physiological tests and questionnaires) and biological (based…
The objective of this study is to characterise and validate multidimensional latent risk and resilience mental health trajectories in a trans-syndromal sample of help-seeking young people, including identifying genetic, environmental, biological,…
Primary: To describe shoulder function, local fatigue and pain symptoms around the shoulders in children with FSHD type 1, before and after balanced shoulder therapy. Secondary: To gain insight into the experience of children and parents and the…
Primary objective: Development of a normal tissue complication probability (NTCP) model for hypothalamic dysfunction (for severe hypothalamic dysfunction, named hypothalamic syndrome) in childhood brain tumor survivors, incorporating cranial…
To test the feasibility and preliminary effectiveness of the MOE! program in young people (12-19 years old) with ABI in four rehabilitation centers (Basalt/Merem/Revant/Heliomare) and update the program where needed based on experiences and outcomes…
Primary Objective: - Evaluate changes in immune response during oral immunotherapy with either peanut or baked milk in children with a mild peanut or cow*s milk allergySecondary Objective: - Compare the immunological changes at baseline and over…
We aim to collect blood cells from 40 patients with monogenic epilepsy, with a preference for patients with a pathogenic variant in SCN1A, reprogram these cells into iPSCs and use these iPSCs for differentiation into neurons and neuronal organoids…
In this study, we are looking at the effectiveness of following phase 3, the maintenance phase, of the Crohn's Disease Exclusion Diet (CDED) compared to normal diet (with or without standard maintenance treatment) in children and adults with…
We aim to identify if pediatric PAH patients have increased plasma IL-1β and IL-18 compared to control participants, as well as increased caspase-1 cleavage and NLRP3, IL-1β and IL-18 mRNA expression in PBMCs, reflective of inflammasome activation.…
Therapeutic nadroparin administration:Primary objective: To develop evidence-based dosing regimens of nadroparin for children in different age groups by means of the objectification of the PK/PD of nadroparin.Secondary objective: 1) Investigate the…
Our primary objective is to collect normative reference values in typically healthy developing children, aged 0 - 18 years, for EEG in combination with ERP and eyetracking, and OCT measurements (For details see also paragraph 5.1).
The aim of this study is to determine whether this smart wristband can actually support patients and their parents in managing the consequences of hypothalamic dysfunction. We will investigate what kind of support patients, parents, or caregivers…
Primary objective:The aim of this study is to investigate the number of children using a bicycle helmet after visiting the emergency department (ED) following a bicycle accident compared to children who have not.Secondary objective:The secondary…