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Neural plasticity and recovery after early and intensive upper extremity motor training in people with cervical spinal cord injury.

This project aims to investigate peripheral and central neuroplasticity following an early (<13 weeks after injury) and intensive (8 weeks of 6 hours of additional therapy) upper extremity motor training program (EIUMT)…

Multi-parametric MRI in patients suspected for muscle invasive bladder cancer: a new local staging paradigm

The aim of this study is to determine whether multiparametric MRI (mpMRI) of the bladder, in combination with an outpatient biopsy for histological confirmation, is a faster, safer, cheaper and therefore more cost-effective way to detect or…

Sentinel node and organ sparing surgery in stage I colon carcinoma (SENTRY trial)

The aim of this study is to reduce the need for colectomy and its* associated morbidity and mortality in patients with high-risk pT1 or low-risk pT2 colon carcinoma after endoscopic polypectomy by performing a (robot-assisted) laparoscopic wedge…

Sequential imaging for suspicion of Prostate cancer Reducing Overdiagnosis and Unnecessary biopsy with Timely diagnosis of significant cancer

The primary objectives of this study are to evaluate the safety and effectiveness of a novel diagnostic approach applying PSA-density and MRI-imaging-based monitoring, as opposed to immediate prostate biopsy, in men with an intermediate risk of…

The prospective data collection initiative on on small bowel, colorectal and anal cancer - a prospective observational cohort study.

The main objectives of this project are:- To start a prospective observational cohort study of patients who have been diagnosed with CRC, small bowel and anal cancer and follow them from time of diagnosis until death.- To prospectively collect data…

Power2Walk: The Impact of Functional Power Training on Participation and Activity in Children with Cerebral Palsy - A Randomized Controlled Trial.

Primary:1. Do twelve weeks of MegaPower training effectively accomplish patient-tailored participation and activity goals in ambulant children with CP, when compared to their usual care? Secondary:1. Do twelve weeks of MegaPower training improve…

Clinical outcomes and cost-effectiveness of a diagnostic and treatment strategy of upfront CTCA plus selective non-invasive functional imaging compared with standard care in patients with chest pain and suspected coronary artery disease

This strategy will result in a reduction reduce the incidence of major adverse cardiovascular events (MACE) defined as death or non-fatal myocardial infarction and appear more efficient than care as usual.