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The Novel Use of Transcutaneous Electrical Nerve Stimulation in Patients with Angina and Non-Obstructive Coronary Arteries; a Pilot Study

To evaluate the effect of transcutaneous electrical nerve stimulation (TENS) in patients with ANOCA on the change in the summary score of the Seattle Angina Questionnaire (SS SAQ) after 1 month treatment with TENS, compared to baseline.

Bifurcation PCI with a hybrid strategy with drug eluting balloons versus a stepwise provisional two-stent strategy. A randomized controlled single-blinded multicentre trial and registry

In this study we will compare a hybrid DEB strategy with a conventional bailout 2-stent strategy (TAP/T-stenting or Culotte) in patients with a bifurcation lesion with sub-optimal side-branch result. The primary endpoint will be the composite…

The safety and cost-effectiveness of discontinuing disease-modifying therapies in stable relapsing-onset multiple sclerosis (DOT-MS): a randomized rater-blinded multicenter trial.

The aim of this study is to identify whether it is possible to safely discontinue treatment in stable RRMS patients who have shown no evidence of active inflammation in the years prior to inclusion in terms of the return of inflammatory disease…

Transcatheter Mitral Valve Replacement with the Medtronic Intrepid* TMVR Transfemoral System in patients with severe symptomatic mitral regurgitation - APOLLO-EU Trial

Evaluate the safety and efficacy of Medtronic Intrepid* TMVR TF System in patients with moderate-to-severe or severe symptomatic mitral regurgitation who, or moderate symptomatic mitral regurgitation combined with mitral stenosis in the presence of…

Clinical outcomes and cost-effectiveness of a diagnostic and treatment strategy of upfront CTCA plus selective non-invasive functional imaging compared with standard care in patients with chest pain and suspected coronary artery disease

This strategy will result in a reduction reduce the incidence of major adverse cardiovascular events (MACE) defined as death or non-fatal myocardial infarction and appear more efficient than care as usual.

An exploratory, non-interventional, single-center study to characterize a set of immune cells in a range of dermatologic diseases

Primary To evaluate the prevalence of specific immune cell subsets in a range of IMID dermatologic disease patients, both between diseases and compared to healthy volunteers  Secondary To evaluate the variability in specific immune cell…

Implementing a new controlled human infection model with a novel Respiratory Syncytial Virus (RS virus) in healthy volunteers.

The main objective of the study is to establish a controlled human infection model (CHIM) for RSV for future drug and vaccine testing and to identify the inoculation dose needed to induce RSV infection with this new strain in 50-70% of exposed…