45 results
This study will determine whether there is a difference in disease free survival for patients treated with either a 1cm excision margin or 2cm margin for clinical stage II (pT2b-pT4b) primary cutaneous melanoma (AJCC 8th edition, Table 1). The…
The aim of the RADICES study is to investigate the effects of a 12-week exercise and nutrition intervention for patients with metastatic oesophageal or gastric cancer. The intervention will be completely tailored to the condition and nutritional…
Our objective is to compare the efficacy of early chest tube removal combined with single-shot PVB versus standard treatment (chest tube for at least 3 days and thoracic epidural analgesia (TEA)) after surgery for PSP. Efficacy is defined as…
To investigate the effect of implementing continuous antepartum eCTG monitoring at the OHC, on perinatal and maternal outcomes and obstetric care
This strategy will result in a reduction reduce the incidence of major adverse cardiovascular events (MACE) defined as death or non-fatal myocardial infarction and appear more efficient than care as usual.
The main objective is to study the effect of the nutritional intervention versus the control product on white matter development (as assessed using tract based spatial statistics of fractional anisotropy) using a DTI scan at the corrected age of…
To evaluate RRS with delayed RRO as an alternative for RRSO in BRCA1/2 gene germline mutation carriers. We hypothesize that RRS with delayed RRO leads to an equal ovarian cancer incidence when compared to RRSO.
Given the above mentioned gaps in knowledge, the aim of this project is to1) Describe the midterm and long-term outcomes of (primary and revision) total hip, total knee and shoulder replacement surgery in terms of health status as a whole,…
To compare safety and efficacy of treatment with sentinel lymph node biopsy guided elective neck irradiation versus standard elective neck irradiation in patients receiving definitive (chemo)radiotherapy for squamous cell carcinoma of the…
This study will consist of three parts with three different main objectives:- Part 1 - Pilot study; Primary objective: To assess and compare thermal comfort upon wearing a cooling vest, based on exposed cooling packs versus…
Primary Objective The primary objective of this study is to compare the 3-year overall survival of stage III NSCLC patients during follow-up surveillance with 18F FDG PET/CT versus follow-up with conventional CT surveillance. Secondary…
To compare the objective response rate between patients with metastatic non-small cell lung cancer characterized by PDL-1 TPS<50% and low TMB and either actionable mutation, inactivating STK11, KEAP1 or NFE2L2 mutations, treated by…
To investigate in healthy individuals not having ELP whether DUS and dynamic MRI may reveal a compressed popliteal artery in rest and during provocative testing (pointing, plantar foot flexion).
The purpose of this study is to evaluate the feasibility and efficiency of transducing freshly obtained CD34+ HSC from either mobilized peripheral blood or bone marrow of healthy donors using lentiviral SIN vectors encoding codon-optimized human…
To assess inter-individual and intra-individual variation in objective skin pigmentation measurement using non-invasive colorimetry and multispectral imaging in healthy individuals and patients with skin disease.
The main objective of the SOPI study is to select the HRD test that best predicts longest PFS on PARP-i in non-BRCA1/2 EOC patients, in order to adequately select patients that will benefit from a PARP-i. Secondary objectives are: to…
The primary objective of this study is to evaluate the adherence to a 3-month gamification intervention integrated with a recently developed platform for continuous lifestyle monitoring (Care-On) in patients with recurrent atrial…
To evaluate the feasibility of remote eCTG monitoring in complicated pregnancies between 32-37 weeks in a Home@Hospital setting. Secondary objectives are to evaluate automated interpretation of remote eCTG monitoring and to assess perinatal and…
To compare postamputation pain (phantom limb pain and residual limb pain) one year postoperatively in patients receiving a lower extremity amputation with standard neurectomy versus those who received targeted muscle reinnervation.
Primary Objective: Primary Objective: 1. To investigate the effect of a VR modality as an education tool for patients undergoing oncological lung resection, compared to standard-of-care patient education in managing preoperative anxiety. 2. To…